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• W2142709339 abstract "You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Basic Research I1 Apr 201232 EFFECT OF α-1 ADRENOCEPTOR ANTAGONIST AND PDE5 INHIBITOR ON C-FOS AND NERVE GROWTH FACTOR EXPRESSION IN THE CENTRAL MICTURITION AREAS: HYPERTENSION ASSOCIATED RAT MODEL Khae-Hawn Kim, Sang Jin Yoon, Han Jung, Tae Beom Kim, Kyung Jin Chung, Jin Kyu Oh, Yong Gil Na, Young Sam Cho, and Heung Jae Park Khae-Hawn KimKhae-Hawn Kim Incheon, Korea, Republic of More articles by this author , Sang Jin YoonSang Jin Yoon Incheon, Korea, Republic of More articles by this author , Han JungHan Jung Incheon, Korea, Republic of More articles by this author , Tae Beom KimTae Beom Kim Incheon, Korea, Republic of More articles by this author , Kyung Jin ChungKyung Jin Chung Incheon, Korea, Republic of More articles by this author , Jin Kyu OhJin Kyu Oh Incheon, Korea, Republic of More articles by this author , Yong Gil NaYong Gil Na DaeJeon, Korea, Republic of More articles by this author , Young Sam ChoYoung Sam Cho Seoul, Korea, Republic of More articles by this author , and Heung Jae ParkHeung Jae Park Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.075AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The origin of overactive bladder (OAB), which is a leading cause of lower urinary tract symptoms (LUTS), remains unknown. Few studies have been reported about the relationship between the expression of neurotrophic factors (NGF) and detrusor hyperactivity. Although it is reported that α-1 adrenoceptor (α1-AR) antagonist and PDE5i improves not only voiding symptoms but also storage symptoms, the mechanism remains controversial. This study is designed to investigate the effects of tamsulosin and sildenafil on central micturition reflex by the degree of neuronal activation and NGF expression in the central micturition areas. METHODS SHR and Wistar-ST (Wistar) rats were used for experimental animals. Rats were randomly divided eight groups (n = 8, in each group): the Wistar-control group (G-A), the SHR-control group (G-B), the SHR and 0.01mg/kg, 0.1mg/kg, and 1mg/kg tamsulosin-treated group (G-C to G-E), the SHR and 1mg/kg, 5mg/kg, and 10mg/kg sildenafil-treated group (G-F to G-H). Tamsulosin or sildenafil-treated groups received orally once a day for 30 days. Immunohistochemistry for c-Fos and NGF were performed for the detection of neuronal activity in the medial preoptic area, ventrolateral periaqueductal gray, pontine micturition center and spinal cord; L4-L5. Parameters of awake urodynamics were investigated before and after treatment in Wistar and SHR. The mean blood pressures (BP) of the SHR and Wistar were compared using polyethylene catheter inserted in the femoral artery and connected to a pressure transducer (Harvard Apparatus). RESULTS The mean BP in the SHR increased compared with Wistar. The SHR (G-B) showed enhanced non-voiding contraction (NVC) pressure and duration in compared to control (G-A) . In treatment groups (G-C to G-H), it was significantly suppressed. This suppression was reversely proportional to the dose of tamsulosin and sildenafil. The expression of c-Fos and NGF in all the central nerve system (CNS) regions was significantly enhanced in G-B compared to G-A. In treatment groups (G-C to G-H), it was significantly suppressed in all the CNS regions. This suppression was also reversely proportional to the dose of tamsulosin and sildenafil as the pattern of NVC. CONCLUSIONS Our results demonstrated that irritative LUTS and symptoms of OAB could be alleviated by α1-AR antagonist and/or PDE5i through the suppression of the central neuronal activation and the expression of NGF in the midbrain and brainstem. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e13 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.Metrics Author Information Khae-Hawn Kim Incheon, Korea, Republic of More articles by this author Sang Jin Yoon Incheon, Korea, Republic of More articles by this author Han Jung Incheon, Korea, Republic of More articles by this author Tae Beom Kim Incheon, Korea, Republic of More articles by this author Kyung Jin Chung Incheon, Korea, Republic of More articles by this author Jin Kyu Oh Incheon, Korea, Republic of More articles by this author Yong Gil Na DaeJeon, Korea, Republic of More articles by this author Young Sam Cho Seoul, Korea, Republic of More articles by this author Heung Jae Park Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2142709339 title "32 EFFECT OF α-1 ADRENOCEPTOR ANTAGONIST AND PDE5 INHIBITOR ON C-FOS AND NERVE GROWTH FACTOR EXPRESSION IN THE CENTRAL MICTURITION AREAS: HYPERTENSION ASSOCIATED RAT MODEL" @default.
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