Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142720002> ?p ?o ?g. }
- W2142720002 endingPage "18776" @default.
- W2142720002 startingPage "18759" @default.
- W2142720002 abstract "Drugs with low water solubility are predisposed to poor and variable oral bioavailability and, therefore, to variability in clinical response, that might be overcome through an appropriate formulation of the drug. Polymorphs (anhydrous and solvate/hydrate forms) may resolve these bioavailability problems, but they can be a challenge to ensure physicochemical stability for the entire shelf life of the drug product. Since clinical failures of polymorph drugs have not been uncommon, and some of them have been entirely unexpected, the Food and Drug Administration (FDA) and the International Conference on Harmonization (ICH) has required preliminary and exhaustive screening studies to identify and characterize all the polymorph crystal forms for each drug. In the past, the polymorphism of many drugs was detected fortuitously or through manual time consuming methods; today, drug crystal engineering, in particular, combinatorial chemistry and high-throughput screening, makes it possible to easily and exhaustively identify stable polymorphic and/or hydrate/dehydrate forms of poorly soluble drugs, in order to overcome bioavailability related problems or clinical failures. This review describes the concepts involved, provides examples of drugs characterized by poor solubility for which polymorphism has proven important, outlines the state-of-the-art technologies and discusses the pertinent regulations." @default.
- W2142720002 created "2016-06-24" @default.
- W2142720002 creator A5025687324 @default.
- W2142720002 creator A5037434090 @default.
- W2142720002 date "2015-10-15" @default.
- W2142720002 modified "2023-10-11" @default.
- W2142720002 title "Polymorph Impact on the Bioavailability and Stability of Poorly Soluble Drugs" @default.
- W2142720002 cites W1484880768 @default.
- W2142720002 cites W1498305210 @default.
- W2142720002 cites W1580142972 @default.
- W2142720002 cites W1580694841 @default.
- W2142720002 cites W1590254871 @default.
- W2142720002 cites W1598117897 @default.
- W2142720002 cites W1603963705 @default.
- W2142720002 cites W1823646735 @default.
- W2142720002 cites W1897811193 @default.
- W2142720002 cites W1966719134 @default.
- W2142720002 cites W1968324829 @default.
- W2142720002 cites W1969128347 @default.
- W2142720002 cites W1970457166 @default.
- W2142720002 cites W1972297941 @default.
- W2142720002 cites W1974838032 @default.
- W2142720002 cites W1975760890 @default.
- W2142720002 cites W1982562853 @default.
- W2142720002 cites W1984783903 @default.
- W2142720002 cites W1988508048 @default.
- W2142720002 cites W1992380940 @default.
- W2142720002 cites W1992498833 @default.
- W2142720002 cites W1995008519 @default.
- W2142720002 cites W1998172362 @default.
- W2142720002 cites W2006526214 @default.
- W2142720002 cites W2008946186 @default.
- W2142720002 cites W2015769892 @default.
- W2142720002 cites W2019442653 @default.
- W2142720002 cites W2019519409 @default.
- W2142720002 cites W2019552102 @default.
- W2142720002 cites W2024365788 @default.
- W2142720002 cites W2024469616 @default.
- W2142720002 cites W2026932971 @default.
- W2142720002 cites W2027890779 @default.
- W2142720002 cites W2028990075 @default.
- W2142720002 cites W2029287356 @default.
- W2142720002 cites W2030625360 @default.
- W2142720002 cites W2032688741 @default.
- W2142720002 cites W2039141867 @default.
- W2142720002 cites W2041184806 @default.
- W2142720002 cites W2041282152 @default.
- W2142720002 cites W2042226095 @default.
- W2142720002 cites W2042374673 @default.
- W2142720002 cites W2042871463 @default.
- W2142720002 cites W2043647907 @default.
- W2142720002 cites W2044213793 @default.
- W2142720002 cites W2044493840 @default.
- W2142720002 cites W2044594845 @default.
- W2142720002 cites W2045961350 @default.
- W2142720002 cites W2046720339 @default.
- W2142720002 cites W2047393407 @default.
- W2142720002 cites W2047740672 @default.
- W2142720002 cites W2051671467 @default.
- W2142720002 cites W2056491250 @default.
- W2142720002 cites W2057302806 @default.
- W2142720002 cites W2057448579 @default.
- W2142720002 cites W2057584545 @default.
- W2142720002 cites W2058210013 @default.
- W2142720002 cites W2064259316 @default.
- W2142720002 cites W2066896855 @default.
- W2142720002 cites W2067129640 @default.
- W2142720002 cites W2069032040 @default.
- W2142720002 cites W2069506489 @default.
- W2142720002 cites W2071593616 @default.
- W2142720002 cites W2071919311 @default.
- W2142720002 cites W2073394985 @default.
- W2142720002 cites W2082787452 @default.
- W2142720002 cites W2086999377 @default.
- W2142720002 cites W2087234082 @default.
- W2142720002 cites W2088192197 @default.
- W2142720002 cites W2091239181 @default.
- W2142720002 cites W2094825866 @default.
- W2142720002 cites W2095544809 @default.
- W2142720002 cites W2100558221 @default.
- W2142720002 cites W2101212670 @default.
- W2142720002 cites W2107955565 @default.
- W2142720002 cites W2110853204 @default.
- W2142720002 cites W2111325726 @default.
- W2142720002 cites W2112722416 @default.
- W2142720002 cites W2116136295 @default.
- W2142720002 cites W2118713144 @default.
- W2142720002 cites W2133061394 @default.
- W2142720002 cites W2135303873 @default.
- W2142720002 cites W2135732933 @default.
- W2142720002 cites W2138177332 @default.
- W2142720002 cites W2140699663 @default.
- W2142720002 cites W2141566507 @default.
- W2142720002 cites W2148492340 @default.
- W2142720002 cites W2151823004 @default.
- W2142720002 cites W2156829937 @default.
- W2142720002 cites W2157022524 @default.
- W2142720002 cites W2163196876 @default.