FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142731321> ?p ?o ?g. }

• W2142731321 endingPage "742" @default.
• W2142731321 startingPage "733" @default.
• W2142731321 abstract "The dysfunction of the blood-brain barrier (BBB) occurring after traumatic brain injury (TBI) is mediated by intracerebral neutrophil accumulation, chemokine release (e.g., interleukin (IL)-8) and upregulation of adhesion molecules (e.g., intercellular adhesion molecule (ICAM)-1). In patients with severe TBI, we previously found that elevated cerebrospinal fluid (CSF) IL-8 and soluble (s)ICAM-1 correlate with BBB dysfunction, and this prompted us to concomitantly monitor IL-8, sICAM-1 and their stimulator tumor necrosis factor (TNF)-α in CSF. Potential mechanisms for upregulation of the IL-8 analogue, murine macrophage inflammatory protein (MIP)-2, and sICAM-1 at the BBB were studied using cultured mouse astrocytes and brain microvascular endothelial cells (MVEC). In CSF of seven patients, IL-8 and sICAM-1 were elevated for 19 days after severe TBI, whereas TNF-α exceeded normal values on 9 days. Stimulation of MVEC and astrocytes with TNF-α simultaneously induced the release of MIP-2 reaching saturation by 4–8 hr and of sICAM-1 increasing continuously from 2–4 hr to 12 hr. Augmented sICAM-1 production correlated with enhanced membrane-bound (m)ICAM-1 expression in both cell types (rs = 0.96 and 0.90, P < 0.0001), but was markedly higher in astrocytes. The release of sICAM-1 was not influenced by IL-8 or MIP-2, although astrocytes and MVEC expressed the IL-8/MIP-2 receptor (CXCR-2) as determined by FACS analysis. Instead, we found that sICAM-1 strongly induced MIP-2 secretion by both cell types with kinetics differing from those evoked by TNF-α. If added together, sICAM-1 and TNF-α synergistically induced MIP-2 production suggesting the involvement of two different pathways for MIP-2 regulation. J. Neurosci. Res. 60:733–742, 2000. © 2000 Wiley-Liss, Inc." @default.
• W2142731321 created "2016-06-24" @default.
• W2142731321 creator A5005449011 @default.
• W2142731321 creator A5008586872 @default.
• W2142731321 creator A5011703295 @default.
• W2142731321 creator A5052344781 @default.
• W2142731321 creator A5061235818 @default.
• W2142731321 creator A5074140747 @default.
• W2142731321 date "2000-01-01" @default.
• W2142731321 modified "2023-10-16" @default.
• W2142731321 title "sICAM-1 and TNF-? induce MIP-2 with distinct kinetics in astrocytes and brain microvascular endothelial cells" @default.
• W2142731321 cites W1494101303 @default.
• W2142731321 cites W1495679080 @default.
• W2142731321 cites W1599302006 @default.
• W2142731321 cites W1602964111 @default.
• W2142731321 cites W1769088469 @default.
• W2142731321 cites W1967081185 @default.
• W2142731321 cites W1970357026 @default.
• W2142731321 cites W1970885006 @default.
• W2142731321 cites W1975908033 @default.
• W2142731321 cites W1978409115 @default.
• W2142731321 cites W1983338308 @default.
• W2142731321 cites W2002728988 @default.
• W2142731321 cites W2005035542 @default.
• W2142731321 cites W2005169628 @default.
• W2142731321 cites W2011084670 @default.
• W2142731321 cites W2015930656 @default.
• W2142731321 cites W2016888883 @default.
• W2142731321 cites W2018269249 @default.
• W2142731321 cites W2022932122 @default.
• W2142731321 cites W2024906564 @default.
• W2142731321 cites W2029867276 @default.
• W2142731321 cites W2041703524 @default.
• W2142731321 cites W2043183468 @default.
• W2142731321 cites W2047772729 @default.
• W2142731321 cites W2054132514 @default.
• W2142731321 cites W2058720223 @default.
• W2142731321 cites W2059527092 @default.
• W2142731321 cites W2072658391 @default.
• W2142731321 cites W2074645350 @default.
• W2142731321 cites W2076339827 @default.
• W2142731321 cites W2083911989 @default.
• W2142731321 cites W2084214859 @default.
• W2142731321 cites W2094180811 @default.
• W2142731321 cites W2104698368 @default.
• W2142731321 cites W2113246643 @default.
• W2142731321 cites W2129962589 @default.
• W2142731321 cites W2133068126 @default.
• W2142731321 cites W2141396178 @default.
• W2142731321 cites W2163520160 @default.
• W2142731321 cites W2168878865 @default.
• W2142731321 cites W2249111258 @default.
• W2142731321 cites W2338547355 @default.
• W2142731321 cites W348761501 @default.
• W2142731321 doi "https://doi.org/10.1002/1097-4547(20000615)60:6<733::aid-jnr5>3.0.co;2-x" @default.
• W2142731321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10861785" @default.
• W2142731321 hasPublicationYear "2000" @default.
• W2142731321 type Work @default.
• W2142731321 sameAs 2142731321 @default.
• W2142731321 citedByCount "70" @default.
• W2142731321 countsByYear W21427313212012 @default.
• W2142731321 countsByYear W21427313212013 @default.
• W2142731321 countsByYear W21427313212014 @default.
• W2142731321 countsByYear W21427313212015 @default.
• W2142731321 countsByYear W21427313212016 @default.
• W2142731321 countsByYear W21427313212017 @default.
• W2142731321 countsByYear W21427313212018 @default.
• W2142731321 countsByYear W21427313212019 @default.
• W2142731321 countsByYear W21427313212020 @default.
• W2142731321 countsByYear W21427313212021 @default.
• W2142731321 countsByYear W21427313212022 @default.
• W2142731321 countsByYear W21427313212023 @default.
• W2142731321 crossrefType "journal-article" @default.
• W2142731321 hasAuthorship W2142731321A5005449011 @default.
• W2142731321 hasAuthorship W2142731321A5008586872 @default.
• W2142731321 hasAuthorship W2142731321A5011703295 @default.
• W2142731321 hasAuthorship W2142731321A5052344781 @default.
• W2142731321 hasAuthorship W2142731321A5061235818 @default.
• W2142731321 hasAuthorship W2142731321A5074140747 @default.
• W2142731321 hasConcept C104317684 @default.
• W2142731321 hasConcept C123012128 @default.
• W2142731321 hasConcept C127561419 @default.
• W2142731321 hasConcept C13373296 @default.
• W2142731321 hasConcept C134018914 @default.
• W2142731321 hasConcept C142724271 @default.
• W2142731321 hasConcept C16224149 @default.
• W2142731321 hasConcept C170217031 @default.
• W2142731321 hasConcept C17991360 @default.
• W2142731321 hasConcept C185592680 @default.
• W2142731321 hasConcept C185946421 @default.
• W2142731321 hasConcept C202751555 @default.
• W2142731321 hasConcept C203014093 @default.
• W2142731321 hasConcept C2776914184 @default.
• W2142731321 hasConcept C2777542381 @default.
• W2142731321 hasConcept C2778402981 @default.
• W2142731321 hasConcept C2778690821 @default.
• W2142731321 hasConcept C2779651940 @default.
• W2142731321 hasConcept C2909375385 @default.

• next