FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142751548> ?p ?o ?g. }

• W2142751548 endingPage "26" @default.
• W2142751548 startingPage "20" @default.
• W2142751548 abstract "The derivation of safe levels of exposure in humans for compounds that are assumed to cause threshold toxicity has relied on the application of a 100-fold uncertainty factor to a measure for the threshold, such as the no observed adverse effect level (NOAEL) or the benchmark dose (BMD). This 100-fold safety factor consists of the product of two 10-fold factors allowing for human variability and interspecies differences. The International Programme on Chemical Safety has suggested the subdivision of these 10-fold factors to allow for variability in toxicokinetics and toxicodynamics. This subdivision allows the replacement of the default uncertainty factors with a chemical-specific adjustment factor (CSAF) when suitable data are available. This short review describes potential options to refine safety factors used in risk assessment, with particular emphasis on pathway-related uncertainty factors associated with variability in kinetics. These pathway-related factors were derived from a database that quantified interspecies differences and human variability in phase I metabolism, phase II metabolism, and renal excretion. This approach allows metabolism and pharmacokinetic data in healthy adults and subgroups of the population to be incorporated in the risk-assessment process and constitutes an intermediate approach between simple default factors and chemical-specific adjustment factors." @default.
• W2142751548 created "2016-06-24" @default.
• W2142751548 creator A5046324513 @default.
• W2142751548 creator A5078234115 @default.
• W2142751548 date "2005-03-30" @default.
• W2142751548 modified "2023-10-16" @default.
• W2142751548 title "The Refinement of Uncertainty/Safety Factors in Risk Assessment by the Incorporation of Data on Toxicokinetic Variability in Humans" @default.
• W2142751548 cites W1889788043 @default.
• W2142751548 cites W196509659 @default.
• W2142751548 cites W1965333201 @default.
• W2142751548 cites W1967866094 @default.
• W2142751548 cites W1970974947 @default.
• W2142751548 cites W1975436708 @default.
• W2142751548 cites W1977948051 @default.
• W2142751548 cites W1978273829 @default.
• W2142751548 cites W1979666222 @default.
• W2142751548 cites W1981328065 @default.
• W2142751548 cites W1985186601 @default.
• W2142751548 cites W1989254015 @default.
• W2142751548 cites W1992592769 @default.
• W2142751548 cites W1999354809 @default.
• W2142751548 cites W1999807086 @default.
• W2142751548 cites W2004458991 @default.
• W2142751548 cites W2004557299 @default.
• W2142751548 cites W2006597998 @default.
• W2142751548 cites W2013893930 @default.
• W2142751548 cites W2014223607 @default.
• W2142751548 cites W2016626346 @default.
• W2142751548 cites W2028138874 @default.
• W2142751548 cites W2029146939 @default.
• W2142751548 cites W2029328602 @default.
• W2142751548 cites W2033751431 @default.
• W2142751548 cites W2042228646 @default.
• W2142751548 cites W2047462380 @default.
• W2142751548 cites W2050146333 @default.
• W2142751548 cites W2050678950 @default.
• W2142751548 cites W2056002608 @default.
• W2142751548 cites W2066312456 @default.
• W2142751548 cites W2078072158 @default.
• W2142751548 cites W2078758468 @default.
• W2142751548 cites W2081243063 @default.
• W2142751548 cites W2083356663 @default.
• W2142751548 cites W2088627293 @default.
• W2142751548 cites W2092397950 @default.
• W2142751548 cites W2097958053 @default.
• W2142751548 cites W2107613102 @default.
• W2142751548 cites W2123828545 @default.
• W2142751548 cites W2132873473 @default.
• W2142751548 cites W2140268893 @default.
• W2142751548 cites W2146793586 @default.
• W2142751548 cites W2155126430 @default.
• W2142751548 cites W2162674333 @default.
• W2142751548 cites W2170181715 @default.
• W2142751548 cites W4243179205 @default.
• W2142751548 doi "https://doi.org/10.1093/toxsci/kfi160" @default.
• W2142751548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15800035" @default.
• W2142751548 hasPublicationYear "2005" @default.
• W2142751548 type Work @default.
• W2142751548 sameAs 2142751548 @default.
• W2142751548 citedByCount "116" @default.
• W2142751548 countsByYear W21427515482012 @default.
• W2142751548 countsByYear W21427515482013 @default.
• W2142751548 countsByYear W21427515482014 @default.
• W2142751548 countsByYear W21427515482015 @default.
• W2142751548 countsByYear W21427515482016 @default.
• W2142751548 countsByYear W21427515482017 @default.
• W2142751548 countsByYear W21427515482018 @default.
• W2142751548 countsByYear W21427515482019 @default.
• W2142751548 countsByYear W21427515482020 @default.
• W2142751548 countsByYear W21427515482021 @default.
• W2142751548 countsByYear W21427515482022 @default.
• W2142751548 countsByYear W21427515482023 @default.
• W2142751548 crossrefType "journal-article" @default.
• W2142751548 hasAuthorship W2142751548A5046324513 @default.
• W2142751548 hasAuthorship W2142751548A5078234115 @default.
• W2142751548 hasBestOaLocation W21427515481 @default.
• W2142751548 hasConcept C112705442 @default.
• W2142751548 hasConcept C112930515 @default.
• W2142751548 hasConcept C12174686 @default.
• W2142751548 hasConcept C149782125 @default.
• W2142751548 hasConcept C195289149 @default.
• W2142751548 hasConcept C19749203 @default.
• W2142751548 hasConcept C2780465076 @default.
• W2142751548 hasConcept C2908647359 @default.
• W2142751548 hasConcept C33070731 @default.
• W2142751548 hasConcept C33923547 @default.
• W2142751548 hasConcept C38652104 @default.
• W2142751548 hasConcept C41008148 @default.
• W2142751548 hasConcept C71924100 @default.
• W2142751548 hasConcept C86803240 @default.
• W2142751548 hasConcept C98274493 @default.
• W2142751548 hasConcept C99454951 @default.
• W2142751548 hasConceptScore W2142751548C112705442 @default.
• W2142751548 hasConceptScore W2142751548C112930515 @default.
• W2142751548 hasConceptScore W2142751548C12174686 @default.
• W2142751548 hasConceptScore W2142751548C149782125 @default.
• W2142751548 hasConceptScore W2142751548C195289149 @default.
• W2142751548 hasConceptScore W2142751548C19749203 @default.

• next