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• W2142752305 abstract "Abstract Purpose The study aimed at evaluating the expression of androgen receptor ( AR ) and nuclear survivin ( NS ) in periocular sebaceous gland carcinoma ( SGC ) and to determine whether this expression is associated with histopathological features, markers of apoptosis and proliferation and with clinical outcomes. Methods This was a retrospective, comparative case series which included 56 patients with a biopsy‐proven periocular SGC . Immunohistochemical staining for AR , survivin, p53 and K i‐67 was analysed in all cases. Results All patients expressed AR , p53 and K i‐67 in the nucleus of tumour cells. Twenty‐four patients (42.8%) had a high AR score, and 32 patients (57.2%) had a low AR score. Twenty‐four (42.8%) patients expressed survivin in the nucleus of tumour cells. Nine (37.5%) had a high NS score, and 15 (62.5%) had a low NS score. Patients with a high AR score had a greater recurrence (p < 0.005), higher expression of K i‐67 (p < 0.0001) and a lower p53 expression (p < 0.005). Nuclear expression of survivin correlated with a high K i‐67 labelling index (0.0001) and low p53 expression (<0.005). Neither nuclear expression of survivin nor the NS score correlated with any clinicopathological features. Conclusion Expression of AR significantly impacts prognosis and is thus promising prognostic marker in periocular SGC ." @default.
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• W2142752305 date "2014-06-15" @default.
• W2142752305 modified "2023-09-26" @default.
• W2142752305 title "Periocular sebaceous gland carcinoma: do androgen receptor (NR3C4) and nuclear survivin (BIRC5) have a prognostic significance?" @default.
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• W2142752305 doi "https://doi.org/10.1111/aos.12466" @default.
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