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• W2142759091 abstract "ABSTRACT The cell wall polysaccharide of Streptococcus gordonii 38 functions as a coaggregation receptor for surface adhesins on other members of the oral biofilm community. The structure of this receptor polysaccharide (RPS) is defined by a heptasaccharide repeat that includes a GalNAcβ1→3Gal-containing recognition motif. The same RPS has now been identified from S. gordonii AT, a partially sequenced strain. PCR primers designed from sequences in the genomic database of strain AT were used to identify and partially characterize the S. gordonii 38 RPS gene cluster. This cluster includes genes for seven putative glycosyltransferases, a polysaccharide polymerase (Wzy), an oligosaccharide repeating unit transporter (Wzx), and a galactofuranose mutase, the enzyme that promotes synthesis of UDP-Gal f , one of five predicted RPS precursors. Genes outside this region were identified for the other four nucleotide-linked sugar precursors of RPS biosynthesis, namely, those for formation of UDP-Glc, UDP-Gal, UDP-GalNAc, and dTDP-Rha. Two genes for putative galactose 4-epimerases were identified. The first, designated galE1 , was identified as a pseudogene in the galactose operon, and the second, designated galE2 , was transcribed with three of the four genes for dTDP-Rha biosynthesis (i.e., rmlA , rmlC , and rmlB ). Insertional inactivation of galE2 abolished (i) RPS production, (ii) growth on galactose, and (iii) both UDP-Gal and UDP-GalNAc 4-epimerase activities in cell extracts. Repair of the galE1 pseudogene in this galE2 mutant restored growth on galactose but not RPS production. Cell extracts containing functional GalE1 but not GalE2 contained UDP-Gal 4-epimerase but not UDP-GalNAc 4-epimerase activity. Thus, provision of both UDP-Gal and UDP-GalNAc for RPS production by S. gordonii 38 depends on the dual specificity of the epimerase encoded by galE2 ." @default.
• W2142759091 created "2016-06-24" @default.
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• W2142759091 date "2003-09-15" @default.
• W2142759091 modified "2023-09-27" @default.
• W2142759091 title "Genetic Loci for Coaggregation Receptor Polysaccharide Biosynthesis in <i>Streptococcus gordonii</i> 38" @default.
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• W2142759091 doi "https://doi.org/10.1128/jb.185.18.5419-5430.2003" @default.
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