FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142762238> ?p ?o ?g. }

• W2142762238 endingPage "196" @default.
• W2142762238 startingPage "183" @default.
• W2142762238 abstract "Significant differences in seizure characteristics between inbred mouse strains highlight the importance of genetic predisposition to epilepsy. Here, we examined the genetic differences between the seizure-resistant C57BL/6J (B6) mouse strain and the seizure-susceptible DBA/2J (D2) strain in the phospho-Erk and Fos pathways to examine seizure-induced neuronal activity to uncover potential mechanistic correlates to these disparate seizure responsivities. Expression of neural activity markers was examined following 1, 5, or 8 seizures, or after 8 seizures, a 28 day rest period, and a final flurothyl rechallenge. Two brain regions, the hippocampus and ventromedial nucleus of the hypothalamus (VMH), had significantly different Fos expression profiles following seizures. Fos expression was highly robust in B6 hippocampus following one seizure and remained elevated following multiple seizures. Conversely, there was an absence of Fos (and phospho-Erk) expression in D2 hippocampus following one generalized seizure that increased with multiple seizures. This lack of Fos expression occurred despite intracranial electroencephalographic recordings indicating that the D2 hippocampus propagated ictal discharge during the first flurothyl seizure suggesting a dissociation of seizure discharge from Fos and phospho-Erk expression. Global transcriptional analysis confirmed a dysregulation of the c-fos pathway in D2 mice following 1 seizure. Moreover, global analysis of RNA expression differences between B6 and D2 hippocampus revealed a unique pattern of transcripts that were co-regulated with Fos in D2 hippocampus following 1 seizure. These expression differences could, in part, account for D2's seizure susceptibility phenotype. Following 8 seizures, a 28 day rest period, and a final flurothyl rechallenge, ∼85% of B6 mice develop a more complex seizure phenotype consisting of a clonic-forebrain seizure that uninterruptedly progresses into a brainstem seizure. This seizure phenotype in B6 mice is highly correlated with bilateral Fos expression in the VMH and was not observed in D2 mice, which always express clonic-forebrain seizures upon flurothyl retest. Overall, these results illustrate specific differences in protein and RNA expression in different inbred strains following seizures that precede the reorganizational events that affect seizure susceptibility and changes in seizure semiology over time." @default.
• W2142762238 created "2016-06-24" @default.
• W2142762238 creator A5002873725 @default.
• W2142762238 creator A5020280230 @default.
• W2142762238 creator A5022909525 @default.
• W2142762238 creator A5059436921 @default.
• W2142762238 creator A5061999887 @default.
• W2142762238 creator A5063528003 @default.
• W2142762238 creator A5064361916 @default.
• W2142762238 date "2015-01-01" @default.
• W2142762238 modified "2023-10-18" @default.
• W2142762238 title "Spatiotemporal differences in the c-fos pathway between C57BL/6J and DBA/2J mice following flurothyl-induced seizures: A dissociation of hippocampal Fos from seizure activity" @default.
• W2142762238 cites W124713771 @default.
• W2142762238 cites W1487220629 @default.
• W2142762238 cites W1584917605 @default.
• W2142762238 cites W1845419411 @default.
• W2142762238 cites W1968669108 @default.
• W2142762238 cites W1975451230 @default.
• W2142762238 cites W1975711767 @default.
• W2142762238 cites W1980584574 @default.
• W2142762238 cites W1986782571 @default.
• W2142762238 cites W1994433199 @default.
• W2142762238 cites W1995105699 @default.
• W2142762238 cites W2003381830 @default.
• W2142762238 cites W2008243276 @default.
• W2142762238 cites W2008421344 @default.
• W2142762238 cites W2012390743 @default.
• W2142762238 cites W2014367829 @default.
• W2142762238 cites W2020869644 @default.
• W2142762238 cites W2025440577 @default.
• W2142762238 cites W2026685503 @default.
• W2142762238 cites W2026927993 @default.
• W2142762238 cites W2034998738 @default.
• W2142762238 cites W2035615794 @default.
• W2142762238 cites W2045356884 @default.
• W2142762238 cites W2048730029 @default.
• W2142762238 cites W2049536489 @default.
• W2142762238 cites W2049633200 @default.
• W2142762238 cites W2049800843 @default.
• W2142762238 cites W2056775516 @default.
• W2142762238 cites W2058601367 @default.
• W2142762238 cites W2065157004 @default.
• W2142762238 cites W2066192943 @default.
• W2142762238 cites W2067478068 @default.
• W2142762238 cites W2069328624 @default.
• W2142762238 cites W2073417597 @default.
• W2142762238 cites W2077126634 @default.
• W2142762238 cites W2080251701 @default.
• W2142762238 cites W2082855357 @default.
• W2142762238 cites W2083529434 @default.
• W2142762238 cites W2088878507 @default.
• W2142762238 cites W2090569363 @default.
• W2142762238 cites W2099540110 @default.
• W2142762238 cites W2108480045 @default.
• W2142762238 cites W2118564947 @default.
• W2142762238 cites W2120647734 @default.
• W2142762238 cites W2127049226 @default.
• W2142762238 cites W2139651996 @default.
• W2142762238 cites W2146127468 @default.
• W2142762238 cites W2148543906 @default.
• W2142762238 cites W2153280430 @default.
• W2142762238 cites W2158217645 @default.
• W2142762238 cites W2474425639 @default.
• W2142762238 doi "https://doi.org/10.1016/j.eplepsyres.2014.11.009" @default.
• W2142762238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4272448" @default.
• W2142762238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25524858" @default.
• W2142762238 hasPublicationYear "2015" @default.
• W2142762238 type Work @default.
• W2142762238 sameAs 2142762238 @default.
• W2142762238 citedByCount "14" @default.
• W2142762238 countsByYear W21427622382016 @default.
• W2142762238 countsByYear W21427622382017 @default.
• W2142762238 countsByYear W21427622382018 @default.
• W2142762238 countsByYear W21427622382019 @default.
• W2142762238 countsByYear W21427622382020 @default.
• W2142762238 crossrefType "journal-article" @default.
• W2142762238 hasAuthorship W2142762238A5002873725 @default.
• W2142762238 hasAuthorship W2142762238A5020280230 @default.
• W2142762238 hasAuthorship W2142762238A5022909525 @default.
• W2142762238 hasAuthorship W2142762238A5059436921 @default.
• W2142762238 hasAuthorship W2142762238A5061999887 @default.
• W2142762238 hasAuthorship W2142762238A5063528003 @default.
• W2142762238 hasAuthorship W2142762238A5064361916 @default.
• W2142762238 hasBestOaLocation W21427622382 @default.
• W2142762238 hasConcept C100691959 @default.
• W2142762238 hasConcept C104317684 @default.
• W2142762238 hasConcept C126322002 @default.
• W2142762238 hasConcept C134018914 @default.
• W2142762238 hasConcept C148762608 @default.
• W2142762238 hasConcept C150194340 @default.
• W2142762238 hasConcept C15744967 @default.
• W2142762238 hasConcept C169760540 @default.
• W2142762238 hasConcept C17755696 @default.
• W2142762238 hasConcept C2775858608 @default.
• W2142762238 hasConcept C2776046087 @default.
• W2142762238 hasConcept C2777003273 @default.
• W2142762238 hasConcept C2777010014 @default.
• W2142762238 hasConcept C2778186239 @default.

• next