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- W2142768713 endingPage "45" @default.
- W2142768713 startingPage "27" @default.
- W2142768713 abstract "The identification of genes linked to neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD) and Parkinson’s disease (PD) has led to the development of animal models for studying mechanism and evaluating potential therapies. None of the transgenic models developed based on disease-associated genes have been able to fully recapitulate the behavioral and pathological features of the corresponding disease. However, there has been enormous progress made in identifying potential therapeutic targets and understanding some of the common mechanisms of neurodegeneration. In this review, we will discuss transgenic animal models for AD, ALS, HD and PD that are based on human genetic studies. All of the diseases discussed have active or complete clinical trials for experimental treatments that benefited from transgenic models of the disease." @default.
- W2142768713 created "2016-06-24" @default.
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- W2142768713 creator A5067810513 @default.
- W2142768713 creator A5086681709 @default.
- W2142768713 creator A5086984046 @default.
- W2142768713 date "2010-10-08" @default.
- W2142768713 modified "2023-10-16" @default.
- W2142768713 title "Transgenic animal models of neurodegeneration based on human genetic studies" @default.
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