FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142773939> ?p ?o ?g. }

• W2142773939 endingPage "1156" @default.
• W2142773939 startingPage "1151" @default.
• W2142773939 abstract "Three small retrospective studies have suggested that patients undergoing continuous androgen deprivation (CAD) have superior survival and time to progression if lower castrate levels of testosterone (< 0.7 nmol/L) are achieved. Evidence from prospective large studies has been lacking.The PR-7 study randomly assigned patients experiencing biochemical failure after radiation therapy or surgery plus radiation therapy to CAD or intermittent androgen deprivation. The relationship between testosterone levels in the first year and cause-specific survival (CSS) and time to androgen-independent progression in men in the CAD arm was evaluated using Cox regression.There was a significant difference in CSS (P = .015) and time to hormone resistance (P = .02) among those who had first-year minimum nadir testosterone ≤ 0.7, > 0.7 to ≤ 1.7, and ≥ 1.7 nmol/L. Patients with first-year nadir testosterone consistently > 0.7 nmol/L had significantly higher risks of dying as a result of disease (0.7 to 1.7 nmol/L: hazard ratio [HR], 2.08; 95% CI, 1.28 to 3.38; > 1.7 nmol/L: HR, 2.93; 95% CI, 0.70 to 12.30) and developing hormone resistance (0.7 to 1.7 nmol/L: HR, 1.62; 95% CI, 1.20 to 2.18; ≥ 1.7 nmol/L: HR, 1.90; 95% CI, 0.77 to 4.70). Maximum testosterone ≥ 1.7 nmol/L predicted for a higher risk of dying as a result of disease (P = .02).Low nadir serum testosterone (ie, < 0.7 mmol/L) within the first year of androgen-deprivation therapy correlates with improved CSS and duration of response to androgen deprivation in men being treated for biochemical failure undergoing CAD." @default.
• W2142773939 created "2016-06-24" @default.
• W2142773939 creator A5001591556 @default.
• W2142773939 creator A5002916492 @default.
• W2142773939 creator A5009380716 @default.
• W2142773939 creator A5010847790 @default.
• W2142773939 creator A5021967618 @default.
• W2142773939 creator A5022012720 @default.
• W2142773939 creator A5025921361 @default.
• W2142773939 creator A5027101830 @default.
• W2142773939 creator A5049646055 @default.
• W2142773939 creator A5061721154 @default.
• W2142773939 creator A5078445671 @default.
• W2142773939 date "2015-04-01" @default.
• W2142773939 modified "2023-10-02" @default.
• W2142773939 title "Nadir Testosterone Within First Year of Androgen-Deprivation Therapy (ADT) Predicts for Time to Castration-Resistant Progression: A Secondary Analysis of the PR-7 Trial of Intermittent Versus Continuous ADT" @default.
• W2142773939 cites W1554183270 @default.
• W2142773939 cites W1978285420 @default.
• W2142773939 cites W1989025784 @default.
• W2142773939 cites W1990895663 @default.
• W2142773939 cites W202356157 @default.
• W2142773939 cites W2037416732 @default.
• W2142773939 cites W2049114256 @default.
• W2142773939 cites W2050366955 @default.
• W2142773939 cites W2063882679 @default.
• W2142773939 cites W2081084828 @default.
• W2142773939 cites W2107270081 @default.
• W2142773939 cites W2111328291 @default.
• W2142773939 cites W2115012618 @default.
• W2142773939 cites W2119776733 @default.
• W2142773939 cites W2159437944 @default.
• W2142773939 doi "https://doi.org/10.1200/jco.2014.58.2973" @default.
• W2142773939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4372851" @default.
• W2142773939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25732157" @default.
• W2142773939 hasPublicationYear "2015" @default.
• W2142773939 type Work @default.
• W2142773939 sameAs 2142773939 @default.
• W2142773939 citedByCount "130" @default.
• W2142773939 countsByYear W21427739392015 @default.
• W2142773939 countsByYear W21427739392016 @default.
• W2142773939 countsByYear W21427739392017 @default.
• W2142773939 countsByYear W21427739392018 @default.
• W2142773939 countsByYear W21427739392019 @default.
• W2142773939 countsByYear W21427739392020 @default.
• W2142773939 countsByYear W21427739392021 @default.
• W2142773939 countsByYear W21427739392022 @default.
• W2142773939 countsByYear W21427739392023 @default.
• W2142773939 crossrefType "journal-article" @default.
• W2142773939 hasAuthorship W2142773939A5001591556 @default.
• W2142773939 hasAuthorship W2142773939A5002916492 @default.
• W2142773939 hasAuthorship W2142773939A5009380716 @default.
• W2142773939 hasAuthorship W2142773939A5010847790 @default.
• W2142773939 hasAuthorship W2142773939A5021967618 @default.
• W2142773939 hasAuthorship W2142773939A5022012720 @default.
• W2142773939 hasAuthorship W2142773939A5025921361 @default.
• W2142773939 hasAuthorship W2142773939A5027101830 @default.
• W2142773939 hasAuthorship W2142773939A5049646055 @default.
• W2142773939 hasAuthorship W2142773939A5061721154 @default.
• W2142773939 hasAuthorship W2142773939A5078445671 @default.
• W2142773939 hasBestOaLocation W21427739392 @default.
• W2142773939 hasConcept C121608353 @default.
• W2142773939 hasConcept C126322002 @default.
• W2142773939 hasConcept C126894567 @default.
• W2142773939 hasConcept C134018914 @default.
• W2142773939 hasConcept C207103383 @default.
• W2142773939 hasConcept C2777899217 @default.
• W2142773939 hasConcept C2777911890 @default.
• W2142773939 hasConcept C2779279991 @default.
• W2142773939 hasConcept C2779665388 @default.
• W2142773939 hasConcept C2780192828 @default.
• W2142773939 hasConcept C44249647 @default.
• W2142773939 hasConcept C50382708 @default.
• W2142773939 hasConcept C71315377 @default.
• W2142773939 hasConcept C71924100 @default.
• W2142773939 hasConceptScore W2142773939C121608353 @default.
• W2142773939 hasConceptScore W2142773939C126322002 @default.
• W2142773939 hasConceptScore W2142773939C126894567 @default.
• W2142773939 hasConceptScore W2142773939C134018914 @default.
• W2142773939 hasConceptScore W2142773939C207103383 @default.
• W2142773939 hasConceptScore W2142773939C2777899217 @default.
• W2142773939 hasConceptScore W2142773939C2777911890 @default.
• W2142773939 hasConceptScore W2142773939C2779279991 @default.
• W2142773939 hasConceptScore W2142773939C2779665388 @default.
• W2142773939 hasConceptScore W2142773939C2780192828 @default.
• W2142773939 hasConceptScore W2142773939C44249647 @default.
• W2142773939 hasConceptScore W2142773939C50382708 @default.
• W2142773939 hasConceptScore W2142773939C71315377 @default.
• W2142773939 hasConceptScore W2142773939C71924100 @default.
• W2142773939 hasIssue "10" @default.
• W2142773939 hasLocation W21427739391 @default.
• W2142773939 hasLocation W21427739392 @default.
• W2142773939 hasLocation W21427739393 @default.
• W2142773939 hasLocation W21427739394 @default.
• W2142773939 hasOpenAccess W2142773939 @default.
• W2142773939 hasPrimaryLocation W21427739391 @default.
• W2142773939 hasRelatedWork W1965833776 @default.
• W2142773939 hasRelatedWork W1977493149 @default.
• W2142773939 hasRelatedWork W1979102595 @default.

• next