FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142781849> ?p ?o ?g. }

• W2142781849 endingPage "2622" @default.
• W2142781849 startingPage "2613" @default.
• W2142781849 abstract "The mechanisms underlying mucus-associated pathologies in cystic fibrosis (CF) remain obscure. However, recent studies indicate that CF transmembrane conductance regulator (CFTR) is required for bicarbonate (HCO3-) transport and that HCO3- is critical for normal mucus formation. We therefore investigated the role of HCO3- in mucus secretion using mouse small intestine segments ex vivo. Basal rates of mucus release in the presence or absence of HCO3- were similar. However, in the absence of HCO3-, mucus release stimulated by either PGE2 or 5-hydroxytryptamine (5-HT) was approximately half that stimulated by these molecules in the presence of HCO3-. Inhibition of HCO3- and fluid transport markedly reduced stimulated mucus release. However, neither absence of HCO3- nor inhibition of HCO3- transport affected fluid secretion rates, indicating that the effect of HCO3- removal on mucus release was not due to decreased fluid secretion. In a mouse model of CF (mice homozygous for the most common human CFTR mutation), intestinal mucus release was minimal when stimulated with either PGE2 or 5-HT in the presence or absence of HCO3-. These data suggest that normal mucus release requires concurrent HCO3- secretion and that the characteristically aggregated mucus observed in mucin-secreting organs in individuals with CF may be a consequence of defective HCO3- transport." @default.
• W2142781849 created "2016-06-24" @default.
• W2142781849 creator A5008073510 @default.
• W2142781849 creator A5073519974 @default.
• W2142781849 creator A5079815759 @default.
• W2142781849 date "2009-09-01" @default.
• W2142781849 modified "2023-10-14" @default.
• W2142781849 title "Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator–dependent bicarbonate secretion" @default.
• W2142781849 cites W1536163743 @default.
• W2142781849 cites W168788800 @default.
• W2142781849 cites W1968784553 @default.
• W2142781849 cites W1971284145 @default.
• W2142781849 cites W1972947780 @default.
• W2142781849 cites W1987706317 @default.
• W2142781849 cites W1993860856 @default.
• W2142781849 cites W1997835226 @default.
• W2142781849 cites W2005269914 @default.
• W2142781849 cites W2008062089 @default.
• W2142781849 cites W2009695810 @default.
• W2142781849 cites W2013014565 @default.
• W2142781849 cites W2016417321 @default.
• W2142781849 cites W2020212141 @default.
• W2142781849 cites W2021027104 @default.
• W2142781849 cites W2021639310 @default.
• W2142781849 cites W2022634662 @default.
• W2142781849 cites W2030364983 @default.
• W2142781849 cites W2038062523 @default.
• W2142781849 cites W2043659802 @default.
• W2142781849 cites W2045176966 @default.
• W2142781849 cites W2053648906 @default.
• W2142781849 cites W2057090803 @default.
• W2142781849 cites W2068812994 @default.
• W2142781849 cites W2074496340 @default.
• W2142781849 cites W2075063025 @default.
• W2142781849 cites W2077264898 @default.
• W2142781849 cites W2080769030 @default.
• W2142781849 cites W2083006717 @default.
• W2142781849 cites W2084617543 @default.
• W2142781849 cites W2090382621 @default.
• W2142781849 cites W2101927153 @default.
• W2142781849 cites W2106348311 @default.
• W2142781849 cites W2110148134 @default.
• W2142781849 cites W2123173492 @default.
• W2142781849 cites W2124884472 @default.
• W2142781849 cites W2126146585 @default.
• W2142781849 cites W2128278627 @default.
• W2142781849 cites W2128690195 @default.
• W2142781849 cites W2137012287 @default.
• W2142781849 cites W2147964093 @default.
• W2142781849 cites W2154232984 @default.
• W2142781849 cites W2156521489 @default.
• W2142781849 cites W2163418240 @default.
• W2142781849 cites W2168597652 @default.
• W2142781849 cites W2260255165 @default.
• W2142781849 cites W2305012816 @default.
• W2142781849 cites W2347065379 @default.
• W2142781849 cites W384010788 @default.
• W2142781849 cites W4239619779 @default.
• W2142781849 doi "https://doi.org/10.1172/jci38662" @default.
• W2142781849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2769202" @default.
• W2142781849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19726884" @default.
• W2142781849 hasPublicationYear "2009" @default.
• W2142781849 type Work @default.
• W2142781849 sameAs 2142781849 @default.
• W2142781849 citedByCount "258" @default.
• W2142781849 countsByYear W21427818492012 @default.
• W2142781849 countsByYear W21427818492013 @default.
• W2142781849 countsByYear W21427818492014 @default.
• W2142781849 countsByYear W21427818492015 @default.
• W2142781849 countsByYear W21427818492016 @default.
• W2142781849 countsByYear W21427818492017 @default.
• W2142781849 countsByYear W21427818492018 @default.
• W2142781849 countsByYear W21427818492019 @default.
• W2142781849 countsByYear W21427818492020 @default.
• W2142781849 countsByYear W21427818492021 @default.
• W2142781849 countsByYear W21427818492022 @default.
• W2142781849 countsByYear W21427818492023 @default.
• W2142781849 crossrefType "journal-article" @default.
• W2142781849 hasAuthorship W2142781849A5008073510 @default.
• W2142781849 hasAuthorship W2142781849A5073519974 @default.
• W2142781849 hasAuthorship W2142781849A5079815759 @default.
• W2142781849 hasBestOaLocation W21427818491 @default.
• W2142781849 hasConcept C126322002 @default.
• W2142781849 hasConcept C134018914 @default.
• W2142781849 hasConcept C179264091 @default.
• W2142781849 hasConcept C185592680 @default.
• W2142781849 hasConcept C18903297 @default.
• W2142781849 hasConcept C2776938444 @default.
• W2142781849 hasConcept C2777312293 @default.
• W2142781849 hasConcept C2778428886 @default.
• W2142781849 hasConcept C2781112554 @default.
• W2142781849 hasConcept C49039625 @default.
• W2142781849 hasConcept C55493867 @default.
• W2142781849 hasConcept C71924100 @default.
• W2142781849 hasConcept C86803240 @default.
• W2142781849 hasConceptScore W2142781849C126322002 @default.
• W2142781849 hasConceptScore W2142781849C134018914 @default.
• W2142781849 hasConceptScore W2142781849C179264091 @default.

• next