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- W2142787149 endingPage "224" @default.
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- W2142787149 abstract "Many compound screening collections are populated by members that possess a low degree of structural complexity. In an effort to generate compounds that are both complex and diverse, we have developed a strategy that uses natural products as a starting point for complex molecule synthesis. Herein we apply this complexity-to-diversity approach to abietic acid, an abundant natural product used commercially in paints, varnishes, and lacquers. From abietic acid we synthesize a collection of complex (as assessed by fraction of sp3-hybridized carbons and number of stereogenic centers) and diverse (as assessed by Tanimoto analysis) small molecules. The 84 compounds constructed herein, and those created through similar efforts, should find utility in a variety of biological screens." @default.
- W2142787149 created "2016-06-24" @default.
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- W2142787149 date "2013-11-24" @default.
- W2142787149 modified "2023-10-07" @default.
- W2142787149 title "Synthesis of Complex and Diverse Compounds through Ring Distortion of Abietic Acid" @default.
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- W2142787149 doi "https://doi.org/10.1002/anie.201308743" @default.
- W2142787149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24273016" @default.
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