FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142797188> ?p ?o ?g. }

• W2142797188 endingPage "5593" @default.
• W2142797188 startingPage "5587" @default.
• W2142797188 abstract "To date, delivery of neurotrophic factors has only allowed to transiently protect axotomized facial motoneurons against cell death. In the present report, long-term protection of these neurons was evaluated by continuously expressing the neurotrophic factor glial cell line-derived neurotrophic factor (GDNF) within the facial nucleus using a lentiviral vector system. The viral vector was injected unilaterally into the facial nucleus of 4-month-old Balb/C mice. In contrast to axotomy in other adult rodents, facial nerve lesion in these animals leads to a progressive and sustained loss and/or atrophy of >50% of the motoneurons. This model thus represents an attractive model to evaluate potential protective effects of neurotrophic factors for adult-onset motoneuron diseases, such as amyotrophic lateral sclerosis. One month after unilateral lentiviral vector injection, the facial nerve was sectioned, and the animals were killed 3 months later. Viral delivery of the GDNF gene led to long-term expression and extensive diffusion of GDNF within the brainstem. In addition, axotomized motoneurons were completely protected against cell death, because 95% of the motoneurons were present as demonstrated by both Nissl staining and choline acetyltransferase immunoreactivity. Furthermore, GDNF prevented lesion-induced neuronal atrophy and maintained proximal motoneuron axons, despite the absence of target cell reinnervation. This is the first evidence that viral-mediated delivery of GDNF close to the motoneuron cell bodies of the facial nucleus of adult mice can lead to complete and long-term protection against lesion-induced cell death." @default.
• W2142797188 created "2016-06-24" @default.
• W2142797188 creator A5001089917 @default.
• W2142797188 creator A5001356149 @default.
• W2142797188 creator A5009387400 @default.
• W2142797188 creator A5041127003 @default.
• W2142797188 creator A5087753311 @default.
• W2142797188 date "2000-08-01" @default.
• W2142797188 modified "2023-10-10" @default.
• W2142797188 title "Complete and Long-Term Rescue of Lesioned Adult Motoneurons by Lentiviral-Mediated Expression of Glial Cell Line-Derived Neurotrophic Factor in the Facial Nucleus" @default.
• W2142797188 cites W1571410849 @default.
• W2142797188 cites W1976857475 @default.
• W2142797188 cites W1981449360 @default.
• W2142797188 cites W1983777466 @default.
• W2142797188 cites W1984800697 @default.
• W2142797188 cites W1990493026 @default.
• W2142797188 cites W1994452959 @default.
• W2142797188 cites W2002233878 @default.
• W2142797188 cites W2006519535 @default.
• W2142797188 cites W2007349862 @default.
• W2142797188 cites W2009761723 @default.
• W2142797188 cites W2009835677 @default.
• W2142797188 cites W2032985825 @default.
• W2142797188 cites W2033818333 @default.
• W2142797188 cites W2035781629 @default.
• W2142797188 cites W2040286934 @default.
• W2142797188 cites W2046739492 @default.
• W2142797188 cites W2048643640 @default.
• W2142797188 cites W2048935170 @default.
• W2142797188 cites W2063695629 @default.
• W2142797188 cites W2073947804 @default.
• W2142797188 cites W2077770544 @default.
• W2142797188 cites W2078966127 @default.
• W2142797188 cites W2079672852 @default.
• W2142797188 cites W2087100221 @default.
• W2142797188 cites W2091842853 @default.
• W2142797188 cites W2092357265 @default.
• W2142797188 cites W2094666622 @default.
• W2142797188 cites W2096386031 @default.
• W2142797188 cites W2099690691 @default.
• W2142797188 cites W2107768418 @default.
• W2142797188 cites W2132527405 @default.
• W2142797188 cites W2137914324 @default.
• W2142797188 cites W2150857721 @default.
• W2142797188 cites W2150922307 @default.
• W2142797188 cites W2158649743 @default.
• W2142797188 cites W2162073357 @default.
• W2142797188 cites W2168667739 @default.
• W2142797188 cites W4253140965 @default.
• W2142797188 doi "https://doi.org/10.1523/jneurosci.20-15-05587.2000" @default.
• W2142797188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6772542" @default.
• W2142797188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10908595" @default.
• W2142797188 hasPublicationYear "2000" @default.
• W2142797188 type Work @default.
• W2142797188 sameAs 2142797188 @default.
• W2142797188 citedByCount "163" @default.
• W2142797188 countsByYear W21427971882012 @default.
• W2142797188 countsByYear W21427971882013 @default.
• W2142797188 countsByYear W21427971882014 @default.
• W2142797188 countsByYear W21427971882015 @default.
• W2142797188 countsByYear W21427971882016 @default.
• W2142797188 countsByYear W21427971882017 @default.
• W2142797188 countsByYear W21427971882018 @default.
• W2142797188 countsByYear W21427971882020 @default.
• W2142797188 countsByYear W21427971882021 @default.
• W2142797188 countsByYear W21427971882022 @default.
• W2142797188 countsByYear W21427971882023 @default.
• W2142797188 crossrefType "journal-article" @default.
• W2142797188 hasAuthorship W2142797188A5001089917 @default.
• W2142797188 hasAuthorship W2142797188A5001356149 @default.
• W2142797188 hasAuthorship W2142797188A5009387400 @default.
• W2142797188 hasAuthorship W2142797188A5041127003 @default.
• W2142797188 hasAuthorship W2142797188A5087753311 @default.
• W2142797188 hasBestOaLocation W21427971881 @default.
• W2142797188 hasConcept C104317684 @default.
• W2142797188 hasConcept C126322002 @default.
• W2142797188 hasConcept C142724271 @default.
• W2142797188 hasConcept C160539049 @default.
• W2142797188 hasConcept C169760540 @default.
• W2142797188 hasConcept C170493617 @default.
• W2142797188 hasConcept C185856081 @default.
• W2142797188 hasConcept C198399640 @default.
• W2142797188 hasConcept C2779683492 @default.
• W2142797188 hasConcept C2781172350 @default.
• W2142797188 hasConcept C32470452 @default.
• W2142797188 hasConcept C40767141 @default.
• W2142797188 hasConcept C529278444 @default.
• W2142797188 hasConcept C55493867 @default.
• W2142797188 hasConcept C68710172 @default.
• W2142797188 hasConcept C71924100 @default.
• W2142797188 hasConcept C86803240 @default.
• W2142797188 hasConcept C95444343 @default.
• W2142797188 hasConceptScore W2142797188C104317684 @default.
• W2142797188 hasConceptScore W2142797188C126322002 @default.
• W2142797188 hasConceptScore W2142797188C142724271 @default.
• W2142797188 hasConceptScore W2142797188C160539049 @default.
• W2142797188 hasConceptScore W2142797188C169760540 @default.
• W2142797188 hasConceptScore W2142797188C170493617 @default.

• next