Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142853669> ?p ?o ?g. }
- W2142853669 endingPage "20120151" @default.
- W2142853669 startingPage "20120151" @default.
- W2142853669 abstract "Genomic imprinting is widespread in eutherian mammals. Marsupial mammals also have genomic imprinting, but in fewer loci. It has long been thought that genomic imprinting is somehow related to placentation and/or viviparity in mammals, although neither is restricted to mammals. Most imprinted genes are expressed in the placenta. There is no evidence for genomic imprinting in the egg-laying monotreme mammals, despite their short-lived placenta that transfers nutrients from mother to embryo. Post natal genomic imprinting also occurs, especially in the brain. However, little attention has been paid to the primary source of nutrition in the neonate in all mammals, the mammary gland. Differentially methylated regions (DMRs) play an important role as imprinting control centres in each imprinted region which usually comprises both paternally and maternally expressed genes ( PEG s and MEG s). The DMR is established in the male or female germline (the gDMR). Comprehensive comparative genome studies demonstrated that two imprinted regions, PEG10 and IGF2-H19 , are conserved in both marsupials and eutherians and that PEG10 and H19 DMRs emerged in the therian ancestor at least 160 Ma, indicating the ancestral origin of genomic imprinting during therian mammal evolution. Importantly, these regions are known to be deeply involved in placental and embryonic growth. It appears that most maternal gDMRs are always associated with imprinting in eutherian mammals, but emerged at differing times during mammalian evolution. Thus, genomic imprinting could evolve from a defence mechanism against transposable elements that depended on DNA methylation established in germ cells." @default.
- W2142853669 created "2016-06-24" @default.
- W2142853669 creator A5005089107 @default.
- W2142853669 creator A5059662490 @default.
- W2142853669 creator A5076546588 @default.
- W2142853669 date "2013-01-05" @default.
- W2142853669 modified "2023-10-10" @default.
- W2142853669 title "The origin and evolution of genomic imprinting and viviparity in mammals" @default.
- W2142853669 cites W12463181 @default.
- W2142853669 cites W126684448 @default.
- W2142853669 cites W147187739 @default.
- W2142853669 cites W1481762530 @default.
- W2142853669 cites W1658459147 @default.
- W2142853669 cites W1964985881 @default.
- W2142853669 cites W1968443943 @default.
- W2142853669 cites W1971647523 @default.
- W2142853669 cites W1974721067 @default.
- W2142853669 cites W1977174983 @default.
- W2142853669 cites W1978386737 @default.
- W2142853669 cites W1978457136 @default.
- W2142853669 cites W1981459106 @default.
- W2142853669 cites W1983507216 @default.
- W2142853669 cites W1983878712 @default.
- W2142853669 cites W1984855391 @default.
- W2142853669 cites W1985426841 @default.
- W2142853669 cites W1986657034 @default.
- W2142853669 cites W1992371996 @default.
- W2142853669 cites W1995227479 @default.
- W2142853669 cites W1997582331 @default.
- W2142853669 cites W1997820996 @default.
- W2142853669 cites W1998973138 @default.
- W2142853669 cites W1999307118 @default.
- W2142853669 cites W2001206796 @default.
- W2142853669 cites W2001721754 @default.
- W2142853669 cites W2003883868 @default.
- W2142853669 cites W2004722798 @default.
- W2142853669 cites W2013662762 @default.
- W2142853669 cites W2017278367 @default.
- W2142853669 cites W2018201532 @default.
- W2142853669 cites W2022867908 @default.
- W2142853669 cites W2023346582 @default.
- W2142853669 cites W2025594663 @default.
- W2142853669 cites W2025797510 @default.
- W2142853669 cites W2025825364 @default.
- W2142853669 cites W202800831 @default.
- W2142853669 cites W2030314113 @default.
- W2142853669 cites W2030743489 @default.
- W2142853669 cites W2031653320 @default.
- W2142853669 cites W2031950838 @default.
- W2142853669 cites W2032244798 @default.
- W2142853669 cites W2032555022 @default.
- W2142853669 cites W2035169894 @default.
- W2142853669 cites W2038434389 @default.
- W2142853669 cites W2042740271 @default.
- W2142853669 cites W2045233804 @default.
- W2142853669 cites W2045559135 @default.
- W2142853669 cites W2046993728 @default.
- W2142853669 cites W2054191153 @default.
- W2142853669 cites W2054608914 @default.
- W2142853669 cites W2056361636 @default.
- W2142853669 cites W2056474600 @default.
- W2142853669 cites W2057307833 @default.
- W2142853669 cites W2059509189 @default.
- W2142853669 cites W2059968749 @default.
- W2142853669 cites W2060414631 @default.
- W2142853669 cites W2060679900 @default.
- W2142853669 cites W2061276185 @default.
- W2142853669 cites W2061441723 @default.
- W2142853669 cites W2064292038 @default.
- W2142853669 cites W2066293891 @default.
- W2142853669 cites W2069254821 @default.
- W2142853669 cites W2069320956 @default.
- W2142853669 cites W2070310945 @default.
- W2142853669 cites W2070740026 @default.
- W2142853669 cites W2071858898 @default.
- W2142853669 cites W2074816125 @default.
- W2142853669 cites W2075805514 @default.
- W2142853669 cites W2079672500 @default.
- W2142853669 cites W2082258424 @default.
- W2142853669 cites W2084101481 @default.
- W2142853669 cites W2084421005 @default.
- W2142853669 cites W2085610162 @default.
- W2142853669 cites W2086735645 @default.
- W2142853669 cites W2087816724 @default.
- W2142853669 cites W2088435866 @default.
- W2142853669 cites W2088523924 @default.
- W2142853669 cites W2088832142 @default.
- W2142853669 cites W2091158977 @default.
- W2142853669 cites W2091379389 @default.
- W2142853669 cites W2093517093 @default.
- W2142853669 cites W2094889529 @default.
- W2142853669 cites W2096597957 @default.
- W2142853669 cites W2097150261 @default.
- W2142853669 cites W2101167680 @default.
- W2142853669 cites W2103771322 @default.
- W2142853669 cites W2104632504 @default.
- W2142853669 cites W2106909623 @default.
- W2142853669 cites W2110427132 @default.