Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142853863> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2142853863 endingPage "e007869" @default.
- W2142853863 startingPage "e007869" @default.
- W2142853863 abstract "Chiari malformation type I (CM-I) is a congenital hindbrain anomaly that requires surgical decompression in symptomatic patients. Posterior fossa decompression with duraplasty (PFDD) has been widely practiced in Chiari decompression, but dural opening carries a high risk of surgical complications. A minimally invasive technique, dural splitting decompression (DSD), preserves the inner layer of the dura without dural opening and duraplasty, potentially reducing surgical complications, length of operative time and hospital stay, and cost. If DSD is non-inferior to PFDD in terms of clinical improvement, DSD could be an alternative treatment modality for CM-I. So far, no randomised study of surgical treatment of CM-I has been reported. This study aims to evaluate if DSD is an effective, safe and cost-saving treatment modality for adult CM-I patients, and may provide evidence for using the minimally invasive procedure extensively.DECMI is a randomised controlled, single-masked, non-inferiority, single centre clinical trial. Participants meeting the criteria will be randomised to the DSD group and the PFDD group in a 1:1 ratio. The primary outcome is the rate of clinical improvement, which is defined as the complete resolution or partial improvement of the presenting symptoms/signs. The secondary outcomes consist of the incidence of syrinx reduction, postoperative morbidity rates, reoperation rate, quality of life (QoL) and healthcare resource utilisation. A total of 160 patients will be included and followed up at 3 and 12 months postoperatively.The study protocol was approved by the Biological and Medical Ethics Committee of West China Hospital. The findings of this trial will be published in a peer-reviewed scientific journal and presented at scientific conferences.ChiCTR-TRC-14004099." @default.
- W2142853863 created "2016-06-24" @default.
- W2142853863 creator A5009424735 @default.
- W2142853863 creator A5011696826 @default.
- W2142853863 creator A5013814360 @default.
- W2142853863 creator A5036111618 @default.
- W2142853863 creator A5050572872 @default.
- W2142853863 creator A5060548792 @default.
- W2142853863 creator A5063929346 @default.
- W2142853863 creator A5075546886 @default.
- W2142853863 creator A5086992948 @default.
- W2142853863 date "2015-04-29" @default.
- W2142853863 modified "2023-09-22" @default.
- W2142853863 title "A minimally invasive technique for decompression of Chiari malformation type I (DECMI study): study protocol for a randomised controlled trial" @default.
- W2142853863 cites W1606727278 @default.
- W2142853863 cites W1965258725 @default.
- W2142853863 cites W1966829123 @default.
- W2142853863 cites W1967864546 @default.
- W2142853863 cites W1969704743 @default.
- W2142853863 cites W1998317980 @default.
- W2142853863 cites W2044227136 @default.
- W2142853863 cites W2053273771 @default.
- W2142853863 cites W2054229361 @default.
- W2142853863 cites W2055361940 @default.
- W2142853863 cites W2055955587 @default.
- W2142853863 cites W2063280771 @default.
- W2142853863 cites W2064008301 @default.
- W2142853863 cites W2071550079 @default.
- W2142853863 cites W2076106441 @default.
- W2142853863 cites W2081947815 @default.
- W2142853863 cites W2085367160 @default.
- W2142853863 cites W2090100691 @default.
- W2142853863 cites W2092211327 @default.
- W2142853863 cites W2105412428 @default.
- W2142853863 cites W2113484110 @default.
- W2142853863 cites W2124380664 @default.
- W2142853863 cites W2141234022 @default.
- W2142853863 doi "https://doi.org/10.1136/bmjopen-2015-007869" @default.
- W2142853863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4420982" @default.
- W2142853863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25926152" @default.
- W2142853863 hasPublicationYear "2015" @default.
- W2142853863 type Work @default.
- W2142853863 sameAs 2142853863 @default.
- W2142853863 citedByCount "7" @default.
- W2142853863 countsByYear W21428538632017 @default.
- W2142853863 countsByYear W21428538632019 @default.
- W2142853863 countsByYear W21428538632020 @default.
- W2142853863 countsByYear W21428538632023 @default.
- W2142853863 crossrefType "journal-article" @default.
- W2142853863 hasAuthorship W2142853863A5009424735 @default.
- W2142853863 hasAuthorship W2142853863A5011696826 @default.
- W2142853863 hasAuthorship W2142853863A5013814360 @default.
- W2142853863 hasAuthorship W2142853863A5036111618 @default.
- W2142853863 hasAuthorship W2142853863A5050572872 @default.
- W2142853863 hasAuthorship W2142853863A5060548792 @default.
- W2142853863 hasAuthorship W2142853863A5063929346 @default.
- W2142853863 hasAuthorship W2142853863A5075546886 @default.
- W2142853863 hasAuthorship W2142853863A5086992948 @default.
- W2142853863 hasBestOaLocation W21428538631 @default.
- W2142853863 hasConcept C141071460 @default.
- W2142853863 hasConcept C168563851 @default.
- W2142853863 hasConcept C2779480328 @default.
- W2142853863 hasConcept C71924100 @default.
- W2142853863 hasConceptScore W2142853863C141071460 @default.
- W2142853863 hasConceptScore W2142853863C168563851 @default.
- W2142853863 hasConceptScore W2142853863C2779480328 @default.
- W2142853863 hasConceptScore W2142853863C71924100 @default.
- W2142853863 hasIssue "4" @default.
- W2142853863 hasLocation W21428538631 @default.
- W2142853863 hasLocation W21428538632 @default.
- W2142853863 hasLocation W21428538633 @default.
- W2142853863 hasLocation W21428538634 @default.
- W2142853863 hasOpenAccess W2142853863 @default.
- W2142853863 hasPrimaryLocation W21428538631 @default.
- W2142853863 hasRelatedWork W2002120878 @default.
- W2142853863 hasRelatedWork W2003938723 @default.
- W2142853863 hasRelatedWork W2035183491 @default.
- W2142853863 hasRelatedWork W2047967234 @default.
- W2142853863 hasRelatedWork W2076264651 @default.
- W2142853863 hasRelatedWork W2118496982 @default.
- W2142853863 hasRelatedWork W2439875401 @default.
- W2142853863 hasRelatedWork W4238867864 @default.
- W2142853863 hasRelatedWork W2519357708 @default.
- W2142853863 hasRelatedWork W2525756941 @default.
- W2142853863 hasVolume "5" @default.
- W2142853863 isParatext "false" @default.
- W2142853863 isRetracted "false" @default.
- W2142853863 magId "2142853863" @default.
- W2142853863 workType "article" @default.