Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142861335> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2142861335 endingPage "544" @default.
- W2142861335 startingPage "529" @default.
- W2142861335 abstract "p-Aminophenol (PAP) produces nephrotoxicity in rats through a mechanism presumably involving oxidation and conjugation with glutathione (GSH). Recently it was found that PAP also causes nephrotoxicity in mice as evidenced by elevated blood urea nitrogen (BUN) and serum creatinine levels. The objective of this study was to further investigate the mechanism and elucidate the role of GSH in PAP-induced nephrotoxicity in the mouse. Male C57BL/6 mice injected ip with various doses of PAP were sacrificed at 12 hr for measurement of BUN and serum creatinine levels and determination of the extent of renal cortical nonprotein sulfhydryl (NPSH) and GSH depletion. PAP depleted renal cortical NPSH content in a dose- and time-dependent manner. Depletion of NPSH in mouse kidney did not occur at PAP doses below 600 mg/kg. Buthionine sulfoximine, an inhibitor of GSH synthesis, decreased nephrotoxicity. Ascorbate, a reducing agent, prevented PAP-induced nephrotoxicity and attenuated renal cortical NPSH depletion. However, acivicin and aminooxyacetic acid, inhibitors of y-glutamyltranspeptidase and β-lyase, respectively, did not prevent toxicity in the mouse. Piperonyl butoxide, an inhibitor of cytochrome P-450 enzymes, enhanced nephrotoxicity and renal cysteine depletion but not GSH depletion. The results suggest that PAP-induced nephrotoxicity in the mouse may involve oxidation and formation of a GSH conjugate." @default.
- W2142861335 created "2016-06-24" @default.
- W2142861335 creator A5008590914 @default.
- W2142861335 creator A5032963653 @default.
- W2142861335 creator A5078958514 @default.
- W2142861335 date "1999-01-01" @default.
- W2142861335 modified "2023-10-15" @default.
- W2142861335 title "The Role of Glutathione INp-Aminophenol-Induced Nephrotoxicity in the Mouse" @default.
- W2142861335 cites W1535828429 @default.
- W2142861335 cites W1572936019 @default.
- W2142861335 cites W1980582852 @default.
- W2142861335 cites W1994475612 @default.
- W2142861335 cites W2006370393 @default.
- W2142861335 cites W2006688969 @default.
- W2142861335 cites W2031431690 @default.
- W2142861335 cites W2032518573 @default.
- W2142861335 cites W2036069049 @default.
- W2142861335 cites W2043327644 @default.
- W2142861335 cites W2044393814 @default.
- W2142861335 cites W2056533956 @default.
- W2142861335 cites W2071836082 @default.
- W2142861335 cites W2084424724 @default.
- W2142861335 cites W2085896418 @default.
- W2142861335 cites W2086122328 @default.
- W2142861335 cites W2093278986 @default.
- W2142861335 cites W2094357622 @default.
- W2142861335 cites W2098468510 @default.
- W2142861335 cites W2134545328 @default.
- W2142861335 cites W2157289064 @default.
- W2142861335 cites W4210979662 @default.
- W2142861335 doi "https://doi.org/10.3109/01480549909042530" @default.
- W2142861335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10445162" @default.
- W2142861335 hasPublicationYear "1999" @default.
- W2142861335 type Work @default.
- W2142861335 sameAs 2142861335 @default.
- W2142861335 citedByCount "8" @default.
- W2142861335 countsByYear W21428613352012 @default.
- W2142861335 countsByYear W21428613352013 @default.
- W2142861335 countsByYear W21428613352015 @default.
- W2142861335 crossrefType "journal-article" @default.
- W2142861335 hasAuthorship W2142861335A5008590914 @default.
- W2142861335 hasAuthorship W2142861335A5032963653 @default.
- W2142861335 hasAuthorship W2142861335A5078958514 @default.
- W2142861335 hasConcept C126189478 @default.
- W2142861335 hasConcept C126322002 @default.
- W2142861335 hasConcept C134018914 @default.
- W2142861335 hasConcept C178790620 @default.
- W2142861335 hasConcept C181199279 @default.
- W2142861335 hasConcept C185592680 @default.
- W2142861335 hasConcept C2777476445 @default.
- W2142861335 hasConcept C2778176769 @default.
- W2142861335 hasConcept C2780091579 @default.
- W2142861335 hasConcept C2780306776 @default.
- W2142861335 hasConcept C29730261 @default.
- W2142861335 hasConcept C538909803 @default.
- W2142861335 hasConcept C55493867 @default.
- W2142861335 hasConcept C56673219 @default.
- W2142861335 hasConcept C71924100 @default.
- W2142861335 hasConcept C86803240 @default.
- W2142861335 hasConcept C98274493 @default.
- W2142861335 hasConceptScore W2142861335C126189478 @default.
- W2142861335 hasConceptScore W2142861335C126322002 @default.
- W2142861335 hasConceptScore W2142861335C134018914 @default.
- W2142861335 hasConceptScore W2142861335C178790620 @default.
- W2142861335 hasConceptScore W2142861335C181199279 @default.
- W2142861335 hasConceptScore W2142861335C185592680 @default.
- W2142861335 hasConceptScore W2142861335C2777476445 @default.
- W2142861335 hasConceptScore W2142861335C2778176769 @default.
- W2142861335 hasConceptScore W2142861335C2780091579 @default.
- W2142861335 hasConceptScore W2142861335C2780306776 @default.
- W2142861335 hasConceptScore W2142861335C29730261 @default.
- W2142861335 hasConceptScore W2142861335C538909803 @default.
- W2142861335 hasConceptScore W2142861335C55493867 @default.
- W2142861335 hasConceptScore W2142861335C56673219 @default.
- W2142861335 hasConceptScore W2142861335C71924100 @default.
- W2142861335 hasConceptScore W2142861335C86803240 @default.
- W2142861335 hasConceptScore W2142861335C98274493 @default.
- W2142861335 hasIssue "3" @default.
- W2142861335 hasLocation W21428613351 @default.
- W2142861335 hasLocation W21428613352 @default.
- W2142861335 hasOpenAccess W2142861335 @default.
- W2142861335 hasPrimaryLocation W21428613351 @default.
- W2142861335 hasRelatedWork W1601942384 @default.
- W2142861335 hasRelatedWork W1851113781 @default.
- W2142861335 hasRelatedWork W1979168452 @default.
- W2142861335 hasRelatedWork W1989749016 @default.
- W2142861335 hasRelatedWork W2015256044 @default.
- W2142861335 hasRelatedWork W2095289053 @default.
- W2142861335 hasRelatedWork W2122325434 @default.
- W2142861335 hasRelatedWork W2125837976 @default.
- W2142861335 hasRelatedWork W2142861335 @default.
- W2142861335 hasRelatedWork W2913945505 @default.
- W2142861335 hasVolume "22" @default.
- W2142861335 isParatext "false" @default.
- W2142861335 isRetracted "false" @default.
- W2142861335 magId "2142861335" @default.
- W2142861335 workType "article" @default.