FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142863385> ?p ?o ?g. }

• W2142863385 endingPage "1565" @default.
• W2142863385 startingPage "1552" @default.
• W2142863385 abstract "Estrogen increases serum triglyceride (TG) levels and induces hypertriglyceridemia in susceptible women. The effect of raloxifene (RLX), a selective estrogen-receptor modulator, on serum TG has not been studied in detail.The purpose of this study was to examine the effect of RLX on serum TG levels in postmenopausal women with and without osteoporosis, including those with predisposing factors for hypertriglyceridemia.Fasting serum TG levels were assessed over 36 months in 2738 osteoporotic postmenopausal women (mean age, 67 years) assigned to placebo or RLX (60 or 120 mg/d) in an osteoporosis treatment trial and over 24 months in 1318 postmenopausal women without osteoporosis (mean age, 54 years) assigned to placebo or RLX (60 or 150 mg/d) in 3 osteoporosis prevention trials.In the osteoporosis treatment trial, the median serum TG concentration decreased in all groups, but significantly more in the placebo group (placebo, -3.4%; RLX 60 mg/d, -1.4%; RLX 120 mg/d, -1.3%; P = 0.002). In the osteoporosis prevention trials, the percentage change in median serum TG concentration was not significantly different among treatments (P = 0.22). Among women with varying degrees of hypertriglyceridemia at baseline (>2.82, >3.39, and >4.51 mmol/L), the median serum TG level at the end of the study decreased from baseline in all groups, with no significant differences among treatments (P > or = 0.13). The effect of RLX on serum TG level was not influenced by age, smoking status, use of alcohol, or presence of diabetes (P > or = 0.10 for all interactions). Among women in the highest tertile of body mass index (>26.4 kg/m2), RLX increased serum TG levels significantly compared with placebo (placebo, -3%; RLX 60 mg/d, 6%: RLX 120 mg/d, 4%; P < 0.05); the absolute increase from baseline with RLX in this subgroup was 0.05 mmol/L (4.4 mg/dL).RLX did not increase serum TG in postmenopausal women overall or among women with elevated TG levels or evidence of diabetes at baseline. TG levels increased slightly but statistically significantly in women in the upper tertile of body mass index who were treated with RLX." @default.
• W2142863385 created "2016-06-24" @default.
• W2142863385 creator A5013708756 @default.
• W2142863385 date "2001-09-01" @default.
• W2142863385 modified "2023-10-10" @default.
• W2142863385 title "Effect of raloxifene on serum triglycerides in postmenopausal women: influence of predisposing factors for hypertriglyceridemia" @default.
• W2142863385 cites W1970028985 @default.
• W2142863385 cites W1997883187 @default.
• W2142863385 cites W2012242583 @default.
• W2142863385 cites W2049042206 @default.
• W2142863385 cites W2053556342 @default.
• W2142863385 cites W2060215552 @default.
• W2142863385 cites W2068915367 @default.
• W2142863385 cites W2074957097 @default.
• W2142863385 cites W2079327627 @default.
• W2142863385 cites W2111649142 @default.
• W2142863385 cites W2112629831 @default.
• W2142863385 cites W2113264115 @default.
• W2142863385 cites W2118310760 @default.
• W2142863385 cites W2144238512 @default.
• W2142863385 cites W2172185687 @default.
• W2142863385 cites W2290627980 @default.
• W2142863385 cites W2334460513 @default.
• W2142863385 cites W2398681740 @default.
• W2142863385 cites W2409992954 @default.
• W2142863385 cites W2413266354 @default.
• W2142863385 cites W2416002684 @default.
• W2142863385 cites W2417646661 @default.
• W2142863385 cites W2990406756 @default.
• W2142863385 cites W3212023210 @default.
• W2142863385 doi "https://doi.org/10.1016/s0149-2918(01)80127-2" @default.
• W2142863385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11589267" @default.
• W2142863385 hasPublicationYear "2001" @default.
• W2142863385 type Work @default.
• W2142863385 sameAs 2142863385 @default.
• W2142863385 citedByCount "18" @default.
• W2142863385 countsByYear W21428633852012 @default.
• W2142863385 countsByYear W21428633852016 @default.
• W2142863385 countsByYear W21428633852017 @default.
• W2142863385 countsByYear W21428633852018 @default.
• W2142863385 crossrefType "journal-article" @default.
• W2142863385 hasAuthorship W2142863385A5013708756 @default.
• W2142863385 hasConcept C121608353 @default.
• W2142863385 hasConcept C126322002 @default.
• W2142863385 hasConcept C134018914 @default.
• W2142863385 hasConcept C142724271 @default.
• W2142863385 hasConcept C204787440 @default.
• W2142863385 hasConcept C27081682 @default.
• W2142863385 hasConcept C2776541429 @default.
• W2142863385 hasConcept C2776919658 @default.
• W2142863385 hasConcept C2777944059 @default.
• W2142863385 hasConcept C2778163477 @default.
• W2142863385 hasConcept C2778562196 @default.
• W2142863385 hasConcept C2778913445 @default.
• W2142863385 hasConcept C2779889926 @default.
• W2142863385 hasConcept C530470458 @default.
• W2142863385 hasConcept C555293320 @default.
• W2142863385 hasConcept C71924100 @default.
• W2142863385 hasConcept C84606932 @default.
• W2142863385 hasConceptScore W2142863385C121608353 @default.
• W2142863385 hasConceptScore W2142863385C126322002 @default.
• W2142863385 hasConceptScore W2142863385C134018914 @default.
• W2142863385 hasConceptScore W2142863385C142724271 @default.
• W2142863385 hasConceptScore W2142863385C204787440 @default.
• W2142863385 hasConceptScore W2142863385C27081682 @default.
• W2142863385 hasConceptScore W2142863385C2776541429 @default.
• W2142863385 hasConceptScore W2142863385C2776919658 @default.
• W2142863385 hasConceptScore W2142863385C2777944059 @default.
• W2142863385 hasConceptScore W2142863385C2778163477 @default.
• W2142863385 hasConceptScore W2142863385C2778562196 @default.
• W2142863385 hasConceptScore W2142863385C2778913445 @default.
• W2142863385 hasConceptScore W2142863385C2779889926 @default.
• W2142863385 hasConceptScore W2142863385C530470458 @default.
• W2142863385 hasConceptScore W2142863385C555293320 @default.
• W2142863385 hasConceptScore W2142863385C71924100 @default.
• W2142863385 hasConceptScore W2142863385C84606932 @default.
• W2142863385 hasIssue "9" @default.
• W2142863385 hasLocation W21428633851 @default.
• W2142863385 hasLocation W21428633852 @default.
• W2142863385 hasOpenAccess W2142863385 @default.
• W2142863385 hasPrimaryLocation W21428633851 @default.
• W2142863385 hasRelatedWork W1969487403 @default.
• W2142863385 hasRelatedWork W2040576539 @default.
• W2142863385 hasRelatedWork W2050602528 @default.
• W2142863385 hasRelatedWork W2137030708 @default.
• W2142863385 hasRelatedWork W2153956706 @default.
• W2142863385 hasRelatedWork W2159274429 @default.
• W2142863385 hasRelatedWork W2404614629 @default.
• W2142863385 hasRelatedWork W2417935758 @default.
• W2142863385 hasRelatedWork W2436260843 @default.
• W2142863385 hasRelatedWork W2473225074 @default.
• W2142863385 hasVolume "23" @default.
• W2142863385 isParatext "false" @default.
• W2142863385 isRetracted "false" @default.
• W2142863385 magId "2142863385" @default.
• W2142863385 workType "article" @default.