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• W2142880742 abstract "Mild-to-moderate hypothermia is increasingly used for neuroprotection in humans. However, it is unknown whether administration of barbiturate medications in burst-suppressive doses-the gold standard of neuroprotection during neurovascular procedures-provides an additional protective effect under hypothermic conditions. The authors conducted the present study to answer this question.Thirty-two Sprague-Dawley rats were subjected to 90 minutes of middle cerebral artery occlusion and randomly assigned to one of four treatment groups: 1) normothermic controls; 2) methohexital treatment (burst suppression); 3) induction of mild hypothermia (33 degrees C); and 4) induction of mild hypothermia plus methohexital treatment (burst suppression). Local cerebral blood flow was continuously monitored using bilateral laser Doppler flowmetry and electroencephalography. Functional deficits were quantified and recorded during daily neurological examinations. Infarct volumes were assessed histologically after 7 days. Methohexital treatment, mild hypothermia, and mild hypothermia plus methohexital treatment reduced infarct volumes by 32%, 71%, and 66%, respectively, compared with normothermic controls. Furthermore, mild hypothermia therapy provided the best functional outcome, which was not improved by additional barbiturate therapy.The results of this study indicate that barbiturate-induced burst suppression is not required to achieve maximum neuroprotection under mild hypothermic conditions. The magnitude of protection afforded by barbiturates alone appears to be modest compared with that provided by mild hypothermia." @default.
• W2142880742 created "2016-06-24" @default.
• W2142880742 creator A5023370991 @default.
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• W2142880742 creator A5044978775 @default.
• W2142880742 creator A5060637371 @default.
• W2142880742 date "2000-11-01" @default.
• W2142880742 modified "2023-09-25" @default.
• W2142880742 title "No additional neuroprotection provided by barbiturate-induced burst suppression under mild hypothermic conditions in rats subjected to reversible focal ischemia" @default.
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• W2142880742 cites W1970083960 @default.
• W2142880742 cites W1970738472 @default.
• W2142880742 cites W1972155682 @default.
• W2142880742 cites W1972460915 @default.
• W2142880742 cites W1973904255 @default.
• W2142880742 cites W1976678881 @default.
• W2142880742 cites W1977124221 @default.
• W2142880742 cites W1983780464 @default.
• W2142880742 cites W1984287655 @default.
• W2142880742 cites W1986400194 @default.
• W2142880742 cites W1988305374 @default.
• W2142880742 cites W1988356216 @default.
• W2142880742 cites W1993363831 @default.
• W2142880742 cites W1994504422 @default.
• W2142880742 cites W1996604684 @default.
• W2142880742 cites W2000763034 @default.
• W2142880742 cites W2001814380 @default.
• W2142880742 cites W2004352086 @default.
• W2142880742 cites W2007686553 @default.
• W2142880742 cites W2010027846 @default.
• W2142880742 cites W2010633291 @default.
• W2142880742 cites W2011909535 @default.
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• W2142880742 cites W2016773564 @default.
• W2142880742 cites W2019541577 @default.
• W2142880742 cites W2021370073 @default.
• W2142880742 cites W2021423564 @default.
• W2142880742 cites W2037918922 @default.
• W2142880742 cites W2038478540 @default.
• W2142880742 cites W2040403968 @default.
• W2142880742 cites W2048707344 @default.
• W2142880742 cites W2050049396 @default.
• W2142880742 cites W2057470043 @default.
• W2142880742 cites W2061989266 @default.
• W2142880742 cites W2065016050 @default.
• W2142880742 cites W2065417237 @default.
• W2142880742 cites W2070949944 @default.
• W2142880742 cites W2071665004 @default.
• W2142880742 cites W2072881641 @default.
• W2142880742 cites W2073717839 @default.
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• W2142880742 cites W2148503090 @default.
• W2142880742 cites W2148950496 @default.
• W2142880742 cites W2152497454 @default.
• W2142880742 cites W2153849408 @default.
• W2142880742 cites W2166615294 @default.
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• W2142880742 doi "https://doi.org/10.3171/jns.2000.93.5.0835" @default.
• W2142880742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11059666" @default.
• W2142880742 hasPublicationYear "2000" @default.
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