FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142912010> ?p ?o ?g. }

• W2142912010 endingPage "520" @default.
• W2142912010 startingPage "513" @default.
• W2142912010 abstract "Background. Azole resistance is an emerging problem in Aspergillus fumigatus and complicates the management of patients with Aspergillus-related diseases. Selection of azole resistance may occur through exposure to azole fungicides in the environment. In the Netherlands a surveillance network was used to investigate the epidemiology of resistance selection in A. fumigatus. Methods. Clinical A. fumigatus isolates were screened for azole resistance in 8 university hospitals using azole agar dilution plates. Patient information was collected using an online questionnaire and azole-resistant A. fumigatus isolates were analyzed using gene sequencing, susceptibility testing, and genotyping. Air sampling was performed to investigate the presence of resistant isolates in hospitals and domiciles. Results. Between December 2009 and January 2011, 1315 A. fumigatus isolates from 921 patients were screened. A new cyp51A-mediated resistance mechanism (TR46/Y121F/T289A) was observed in 21 azole-resistant isolates from 15 patients in 6 hospitals. TR46/Y121F/T289A isolates were highly resistant to voriconazole (minimum inhibitory concentration ≥16 mg/L). Eight patients presented with invasive aspergillosis due to TR46/Y121F/T289A, and treatment failed in all 5 patients receiving primary therapy with voriconazole. TR46/Y121F/T289A Aspergillus fumigatus was recovered from 6 of 10 sampled environmental sites. Conclusions. We describe the emergence and geographical migration of a voriconazole highly resistant A. fumigatus that was associated with voriconazole treatment failure in patients with invasive aspergillosis. Recovery of TR46/Y121F/T289A from the environment suggests an environmental route of resistance selection. Exposure of A. fumigatus to azole fungicides may facilitate the emergence of new resistance mechanisms over time, thereby compromising the use of azoles in the management of Aspergillus-related diseases." @default.
• W2142912010 created "2016-06-24" @default.
• W2142912010 creator A5001872134 @default.
• W2142912010 creator A5002025325 @default.
• W2142912010 creator A5002027586 @default.
• W2142912010 creator A5010363206 @default.
• W2142912010 creator A5030033036 @default.
• W2142912010 creator A5038241539 @default.
• W2142912010 creator A5050301910 @default.
• W2142912010 creator A5051266076 @default.
• W2142912010 creator A5052440667 @default.
• W2142912010 creator A5052550074 @default.
• W2142912010 creator A5059877526 @default.
• W2142912010 creator A5064822409 @default.
• W2142912010 creator A5067206863 @default.
• W2142912010 creator A5077547611 @default.
• W2142912010 date "2013-05-10" @default.
• W2142912010 modified "2023-10-11" @default.
• W2142912010 title "Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles" @default.
• W2142912010 cites W1988273601 @default.
• W2142912010 cites W2000103160 @default.
• W2142912010 cites W2006636553 @default.
• W2142912010 cites W2008057474 @default.
• W2142912010 cites W2012538966 @default.
• W2142912010 cites W2041015559 @default.
• W2142912010 cites W2067396122 @default.
• W2142912010 cites W2098654234 @default.
• W2142912010 cites W2098823024 @default.
• W2142912010 cites W2098999975 @default.
• W2142912010 cites W2104550360 @default.
• W2142912010 cites W2104743902 @default.
• W2142912010 cites W2107225499 @default.
• W2142912010 cites W2113498073 @default.
• W2142912010 cites W2119279596 @default.
• W2142912010 cites W2120323783 @default.
• W2142912010 cites W2123134253 @default.
• W2142912010 cites W2133000347 @default.
• W2142912010 cites W2137149687 @default.
• W2142912010 cites W2138884951 @default.
• W2142912010 cites W2138888795 @default.
• W2142912010 cites W2146843443 @default.
• W2142912010 cites W2156176896 @default.
• W2142912010 cites W2157444366 @default.
• W2142912010 cites W2160615860 @default.
• W2142912010 cites W2166734004 @default.
• W2142912010 cites W2167177000 @default.
• W2142912010 cites W2167583623 @default.
• W2142912010 cites W2169748580 @default.
• W2142912010 cites W2170596405 @default.
• W2142912010 doi "https://doi.org/10.1093/cid/cit320" @default.
• W2142912010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23667263" @default.
• W2142912010 hasPublicationYear "2013" @default.
• W2142912010 type Work @default.
• W2142912010 sameAs 2142912010 @default.
• W2142912010 citedByCount "294" @default.
• W2142912010 countsByYear W21429120102013 @default.
• W2142912010 countsByYear W21429120102014 @default.
• W2142912010 countsByYear W21429120102015 @default.
• W2142912010 countsByYear W21429120102016 @default.
• W2142912010 countsByYear W21429120102017 @default.
• W2142912010 countsByYear W21429120102018 @default.
• W2142912010 countsByYear W21429120102019 @default.
• W2142912010 countsByYear W21429120102020 @default.
• W2142912010 countsByYear W21429120102021 @default.
• W2142912010 countsByYear W21429120102022 @default.
• W2142912010 countsByYear W21429120102023 @default.
• W2142912010 crossrefType "journal-article" @default.
• W2142912010 hasAuthorship W2142912010A5001872134 @default.
• W2142912010 hasAuthorship W2142912010A5002025325 @default.
• W2142912010 hasAuthorship W2142912010A5002027586 @default.
• W2142912010 hasAuthorship W2142912010A5010363206 @default.
• W2142912010 hasAuthorship W2142912010A5030033036 @default.
• W2142912010 hasAuthorship W2142912010A5038241539 @default.
• W2142912010 hasAuthorship W2142912010A5050301910 @default.
• W2142912010 hasAuthorship W2142912010A5051266076 @default.
• W2142912010 hasAuthorship W2142912010A5052440667 @default.
• W2142912010 hasAuthorship W2142912010A5052550074 @default.
• W2142912010 hasAuthorship W2142912010A5059877526 @default.
• W2142912010 hasAuthorship W2142912010A5064822409 @default.
• W2142912010 hasAuthorship W2142912010A5067206863 @default.
• W2142912010 hasAuthorship W2142912010A5077547611 @default.
• W2142912010 hasBestOaLocation W21429120101 @default.
• W2142912010 hasConcept C176947019 @default.
• W2142912010 hasConcept C203014093 @default.
• W2142912010 hasConcept C2776391196 @default.
• W2142912010 hasConcept C2779175654 @default.
• W2142912010 hasConcept C2779548794 @default.
• W2142912010 hasConcept C2779787849 @default.
• W2142912010 hasConcept C2780315139 @default.
• W2142912010 hasConcept C2780493024 @default.
• W2142912010 hasConcept C2780690907 @default.
• W2142912010 hasConcept C501593827 @default.
• W2142912010 hasConcept C71924100 @default.
• W2142912010 hasConcept C86803240 @default.
• W2142912010 hasConcept C89423630 @default.
• W2142912010 hasConceptScore W2142912010C176947019 @default.
• W2142912010 hasConceptScore W2142912010C203014093 @default.
• W2142912010 hasConceptScore W2142912010C2776391196 @default.

• next