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• W2142917088 abstract "Thresholds for statistical significance when assessing meta-analysis results are being insufficiently demonstrated by traditional 95% confidence intervals and P-values. Assessment of intervention effects in systematic reviews with meta-analysis deserves greater rigour. Methodologies for assessing statistical and clinical significance of intervention effects in systematic reviews were considered. Balancing simplicity and comprehensiveness, an operational procedure was developed, based mainly on The Cochrane Collaboration methodology and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines. We propose an eight-step procedure for better validation of meta-analytic results in systematic reviews (1) Obtain the 95% confidence intervals and the P-values from both fixed-effect and random-effects meta-analyses and report the most conservative results as the main results. (2) Explore the reasons behind substantial statistical heterogeneity using subgroup and sensitivity analyses (see step 6). (3) To take account of problems with multiplicity adjust the thresholds for significance according to the number of primary outcomes. (4) Calculate required information sizes (≈ the a priori required number of participants for a meta-analysis to be conclusive) for all outcomes and analyse each outcome with trial sequential analysis. Report whether the trial sequential monitoring boundaries for benefit, harm, or futility are crossed. (5) Calculate Bayes factors for all primary outcomes. (6) Use subgroup analyses and sensitivity analyses to assess the potential impact of bias on the review results. (7) Assess the risk of publication bias. (8) Assess the clinical significance of the statistically significant review results. If followed, the proposed eight-step procedure will increase the validity of assessments of intervention effects in systematic reviews of randomised clinical trials." @default.
• W2142917088 created "2016-06-24" @default.
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• W2142917088 creator A5027154144 @default.
• W2142917088 creator A5058808040 @default.
• W2142917088 date "2014-11-21" @default.
• W2142917088 modified "2023-10-16" @default.
• W2142917088 title "Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods" @default.
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• W2142917088 cites W1964502734 @default.
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• W2142917088 cites W1968817382 @default.
• W2142917088 cites W1970207080 @default.
• W2142917088 cites W1970437883 @default.
• W2142917088 cites W1970966365 @default.
• W2142917088 cites W1971441597 @default.
• W2142917088 cites W1981501248 @default.
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• W2142917088 cites W1984780757 @default.
• W2142917088 cites W1993536837 @default.
• W2142917088 cites W1993565708 @default.
• W2142917088 cites W1996470340 @default.
• W2142917088 cites W1997889941 @default.
• W2142917088 cites W1998463172 @default.
• W2142917088 cites W2000442546 @default.
• W2142917088 cites W2009432182 @default.
• W2142917088 cites W2011932878 @default.
• W2142917088 cites W2015824469 @default.
• W2142917088 cites W2016188383 @default.
• W2142917088 cites W2030346622 @default.
• W2142917088 cites W2032506622 @default.
• W2142917088 cites W2033585778 @default.
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• W2142917088 cites W2049110830 @default.
• W2142917088 cites W2049852456 @default.
• W2142917088 cites W2055469806 @default.
• W2142917088 cites W2062216009 @default.
• W2142917088 cites W2064347247 @default.
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• W2142917088 cites W2065974896 @default.
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• W2142917088 cites W2084917404 @default.
• W2142917088 cites W2087358018 @default.
• W2142917088 cites W2090132603 @default.
• W2142917088 cites W2097687553 @default.
• W2142917088 cites W2099779318 @default.
• W2142917088 cites W2101146786 @default.
• W2142917088 cites W2104634108 @default.
• W2142917088 cites W2104675861 @default.
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• W2142917088 cites W2157823046 @default.
• W2142917088 cites W2160063906 @default.
• W2142917088 cites W2160795579 @default.
• W2142917088 cites W2162168145 @default.
• W2142917088 cites W2164093802 @default.
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• W2142917088 doi "https://doi.org/10.1186/1471-2288-14-120" @default.
• W2142917088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4251848" @default.
• W2142917088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25416419" @default.
• W2142917088 hasPublicationYear "2014" @default.
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