FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142923099> ?p ?o ?g. }

• W2142923099 abstract "The chaperon heat shock protein 90 (HSP90) constitutes an important target for anti-tumor therapy due to its essential role in the stabilization of oncogenes. However, HSP90 is ubiquitously active to orchestrate protein turnover, chemotherapeutics that target HSP90 may affect immune cells as a significant side effect. Therefore, we asked for potential effects of pharmacological HSP90 inhibition at a therapeutically relevant concentration on human dendritic cells (DCs) as main inducers of both cellular and humoral immune responses, and on human CD4+ T cells as directly activated by DCs and essential to confer B cell help. Unstimulated human monocyte-derived DCs (MO-DCs) were treated with the prototypical HSP90 inhibitor geldanamycin (GA). Based on dose titration studies performed to assess cytotoxic effects, GA was applied at a rather low concentration, comparable to serum levels of clinically used HSP90 inhibitors. The immuno-phenotype (surface markers, cytokines), migratory capacity, allo T cell stimulatory and polarizing properties (proliferation, cytokine pattern) of GA-treated MO-DCs were assessed. Moreover, effects of GA on resting and differentially stimulated CD4+ T cells in terms of cytotoxicity and proliferation were analysed. GA induced partial activation of unstimulated MO-DCs. In contrast, when coapplied in the course of MO-DC stimulation, GA prevented the acquisition of a fully mature DC phenotype. Consequently, this MO-DC population exerted lower allo CD4+ T cell stimulation and cytokine production. Furthermore, GA exerted no cytotoxic effect on resting T cells, but abrogated proliferation of T cells stimulated by MO-DCs at either state of activation or by stimulatory antibodies. HSP90 inhibitors at clinically relevant concentrations may modulate adaptive immune responses both on the level of DC activation and T cell proliferation. Surprisingly, unstimulated DCs may be partially activated by that agent. However, due to the potent detrimental effects of HSP90 inhibitors on stimulated CD4+ T cells, as an outcome a patients T cell responses might be impaired. Therefore, HSP90 inhibitors most probably are not suitable for treatment in combination with immunotherapeutic approaches aimed to induce DC/T cell activation." @default.
• W2142923099 created "2016-06-24" @default.
• W2142923099 creator A5057741229 @default.
• W2142923099 creator A5060164830 @default.
• W2142923099 creator A5076351629 @default.
• W2142923099 date "2014-02-13" @default.
• W2142923099 modified "2023-10-11" @default.
• W2142923099 title "Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB" @default.
• W2142923099 cites W1502937057 @default.
• W2142923099 cites W1516680782 @default.
• W2142923099 cites W1547462939 @default.
• W2142923099 cites W1553847148 @default.
• W2142923099 cites W1616344155 @default.
• W2142923099 cites W1658123640 @default.
• W2142923099 cites W184020152 @default.
• W2142923099 cites W1844276506 @default.
• W2142923099 cites W1965645255 @default.
• W2142923099 cites W1967835933 @default.
• W2142923099 cites W1970700441 @default.
• W2142923099 cites W1981884734 @default.
• W2142923099 cites W1983344891 @default.
• W2142923099 cites W1984387148 @default.
• W2142923099 cites W1985644715 @default.
• W2142923099 cites W1988009411 @default.
• W2142923099 cites W1992482869 @default.
• W2142923099 cites W1993105675 @default.
• W2142923099 cites W1995913787 @default.
• W2142923099 cites W2001448769 @default.
• W2142923099 cites W2003377779 @default.
• W2142923099 cites W2014220379 @default.
• W2142923099 cites W2016589017 @default.
• W2142923099 cites W2016663716 @default.
• W2142923099 cites W2018718597 @default.
• W2142923099 cites W2022267429 @default.
• W2142923099 cites W2022531767 @default.
• W2142923099 cites W2024445068 @default.
• W2142923099 cites W2030858953 @default.
• W2142923099 cites W2044296969 @default.
• W2142923099 cites W2044835625 @default.
• W2142923099 cites W2054019820 @default.
• W2142923099 cites W2055047003 @default.
• W2142923099 cites W2060148257 @default.
• W2142923099 cites W2061903251 @default.
• W2142923099 cites W2062238060 @default.
• W2142923099 cites W2062254683 @default.
• W2142923099 cites W2070922418 @default.
• W2142923099 cites W2074530163 @default.
• W2142923099 cites W2082390299 @default.
• W2142923099 cites W2100219443 @default.
• W2142923099 cites W2108557146 @default.
• W2142923099 cites W2115527176 @default.
• W2142923099 cites W2115855421 @default.
• W2142923099 cites W2129240173 @default.
• W2142923099 cites W2132297834 @default.
• W2142923099 cites W2135385360 @default.
• W2142923099 cites W2142057493 @default.
• W2142923099 cites W2149238402 @default.
• W2142923099 cites W2164481509 @default.
• W2142923099 doi "https://doi.org/10.1186/1756-9966-33-16" @default.
• W2142923099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3926270" @default.
• W2142923099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24524692" @default.
• W2142923099 hasPublicationYear "2014" @default.
• W2142923099 type Work @default.
• W2142923099 sameAs 2142923099 @default.
• W2142923099 citedByCount "10" @default.
• W2142923099 countsByYear W21429230992014 @default.
• W2142923099 countsByYear W21429230992015 @default.
• W2142923099 countsByYear W21429230992016 @default.
• W2142923099 countsByYear W21429230992017 @default.
• W2142923099 countsByYear W21429230992018 @default.
• W2142923099 countsByYear W21429230992021 @default.
• W2142923099 countsByYear W21429230992022 @default.
• W2142923099 crossrefType "journal-article" @default.
• W2142923099 hasAuthorship W2142923099A5057741229 @default.
• W2142923099 hasAuthorship W2142923099A5060164830 @default.
• W2142923099 hasAuthorship W2142923099A5076351629 @default.
• W2142923099 hasBestOaLocation W21429230991 @default.
• W2142923099 hasConcept C104317684 @default.
• W2142923099 hasConcept C127561419 @default.
• W2142923099 hasConcept C154317977 @default.
• W2142923099 hasConcept C185592680 @default.
• W2142923099 hasConcept C202751555 @default.
• W2142923099 hasConcept C203014093 @default.
• W2142923099 hasConcept C205260736 @default.
• W2142923099 hasConcept C2775932338 @default.
• W2142923099 hasConcept C2776090121 @default.
• W2142923099 hasConcept C2778690821 @default.
• W2142923099 hasConcept C2780297055 @default.
• W2142923099 hasConcept C2908647359 @default.
• W2142923099 hasConcept C502942594 @default.
• W2142923099 hasConcept C55493867 @default.
• W2142923099 hasConcept C71924100 @default.
• W2142923099 hasConcept C86803240 @default.
• W2142923099 hasConcept C8891405 @default.
• W2142923099 hasConcept C95444343 @default.
• W2142923099 hasConcept C99454951 @default.
• W2142923099 hasConceptScore W2142923099C104317684 @default.
• W2142923099 hasConceptScore W2142923099C127561419 @default.
• W2142923099 hasConceptScore W2142923099C154317977 @default.
• W2142923099 hasConceptScore W2142923099C185592680 @default.

• next