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• W2142930239 endingPage "1651" @default.
• W2142930239 startingPage "1647" @default.
• W2142930239 abstract "The roots/rhizomes of black cohosh (Cimicifuga racemosa L. (Nutt.) (syn. Actaea racemosa L.) are a popular dietary supplements among women for management of menopausal symptoms. Although not estrogenic, Nω -methylserotonin has been identified in black cohosh as a potent agonist of serotonin 5-HT1A and 5-HT7 receptors. In the present study, in vitro metabolism of Nω -methylserotonin was investigated to gain insights into aspects of the bioavailability of this compound. The major metabolic pathway was determined to be conversion into 5-hydroxyindole acetaldehyde catalyzed by the monoamine oxidase A (MAO-A). 5-Hydroxyindole acetaldehyde could be further oxidized to form 5-hydroxyindole acetic acid by the action of microsomal aldehyde dehydrogenase or reduced to 5-hydroxy tryptophol by the action of aldehyde reductase. The cytochrome P450 enzymes had only a minor role in the metabolism of Nω -methylserotonin and then only when MAO-A was inhibited. In many aspects, the metabolism of Nω -methylserotonin was similar to the metabolism of serotonin, suggesting that this compound is unlikely to elicit CNS effects due to rapid metabolism by the widely distributed MAO-A." @default.
• W2142930239 created "2016-06-24" @default.
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• W2142930239 date "2014-05-12" @default.
• W2142930239 modified "2023-10-16" @default.
• W2142930239 title "Metabolism of N<i>_ω</i>-methylserotonin, a serotonergic constituent of black cohosh (<i>Cimicifuga racemosa</i>, L. (Nutt.)), by human liver microsomes" @default.
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• W2142930239 doi "https://doi.org/10.1002/bmc.3197" @default.
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