FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142940897> ?p ?o ?g. }

• W2142940897 endingPage "1269" @default.
• W2142940897 startingPage "1260" @default.
• W2142940897 abstract "Influenza B viruses with a novel I221L substitution in neuraminidase (NA) conferring high-level resistance to oseltamivir were isolated from an immunocompromised patient after prolonged oseltamivir treatment.Enzymatic characterization of the NAs (Km, Ki) and the in vitro fitness of viruses carrying wild-type or mutated (I221L) NA genes were evaluated. Proportions of wild-type and mutated NA genes were directly quantified in the patient samples. Structural characterizations by X-ray crystallography of a wild-type and I221L variant NA were performed.The Km and Ki revealed that the I221L variant NA had approximately 84 and 51 times lower affinity for oseltamivir carboxylate and zanamivir, respectively, compared with wild-type NA. Viruses with a wild-type or I221L variant NA had similar growth kinetics in Madin-Darby canine kidney (MDCK) cells, and 5 passages in MDCK cells revealed no reversion of the I221L substitution. The crystal structure of the I221L NA and oseltamivir complex showed that the leucine side chain protrudes into the hydrophobic pocket of the active site that accommodates the pentyloxy substituent of oseltamivir.Enzyme kinetic and NA structural analyses provide an explanation for the high level of resistance to oseltamivir while retaining good fitness of viruses carrying I221L variant NA." @default.
• W2142940897 created "2016-06-24" @default.
• W2142940897 creator A5003849228 @default.
• W2142940897 creator A5005742545 @default.
• W2142940897 creator A5024581043 @default.
• W2142940897 creator A5029979171 @default.
• W2142940897 creator A5030727982 @default.
• W2142940897 creator A5031318111 @default.
• W2142940897 creator A5036722309 @default.
• W2142940897 creator A5040337685 @default.
• W2142940897 creator A5042428837 @default.
• W2142940897 creator A5043267123 @default.
• W2142940897 creator A5043361043 @default.
• W2142940897 creator A5047024835 @default.
• W2142940897 creator A5050453569 @default.
• W2142940897 creator A5054344555 @default.
• W2142940897 creator A5062631592 @default.
• W2142940897 creator A5067800806 @default.
• W2142940897 creator A5078194642 @default.
• W2142940897 date "2014-05-03" @default.
• W2142940897 modified "2023-10-17" @default.
• W2142940897 title "A Novel I221L Substitution in Neuraminidase Confers High-Level Resistance to Oseltamivir in Influenza B Viruses" @default.
• W2142940897 cites W1975272103 @default.
• W2142940897 cites W1980851653 @default.
• W2142940897 cites W1988044361 @default.
• W2142940897 cites W1989570984 @default.
• W2142940897 cites W1995408016 @default.
• W2142940897 cites W1995452398 @default.
• W2142940897 cites W2001847353 @default.
• W2142940897 cites W2009428685 @default.
• W2142940897 cites W2026103300 @default.
• W2142940897 cites W2030678438 @default.
• W2142940897 cites W2038840577 @default.
• W2142940897 cites W2038880912 @default.
• W2142940897 cites W2051327011 @default.
• W2142940897 cites W2057595548 @default.
• W2142940897 cites W2059238784 @default.
• W2142940897 cites W2063205025 @default.
• W2142940897 cites W2065419649 @default.
• W2142940897 cites W2105246478 @default.
• W2142940897 cites W2108921801 @default.
• W2142940897 cites W2110116676 @default.
• W2142940897 cites W2111155300 @default.
• W2142940897 cites W2122030378 @default.
• W2142940897 cites W2127130852 @default.
• W2142940897 cites W2128060816 @default.
• W2142940897 cites W2135589357 @default.
• W2142940897 cites W2144081223 @default.
• W2142940897 cites W2144125773 @default.
• W2142940897 cites W2145320830 @default.
• W2142940897 cites W2153232301 @default.
• W2142940897 cites W2154714625 @default.
• W2142940897 cites W2158645259 @default.
• W2142940897 cites W2159812729 @default.
• W2142940897 cites W2160079547 @default.
• W2142940897 cites W2163341755 @default.
• W2142940897 cites W2164343098 @default.
• W2142940897 cites W2165202620 @default.
• W2142940897 cites W2169404274 @default.
• W2142940897 cites W2171272529 @default.
• W2142940897 cites W2180229411 @default.
• W2142940897 cites W4210675630 @default.
• W2142940897 cites W4231030417 @default.
• W2142940897 cites W4248872320 @default.
• W2142940897 doi "https://doi.org/10.1093/infdis/jiu244" @default.
• W2142940897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4176448" @default.
• W2142940897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24795482" @default.
• W2142940897 hasPublicationYear "2014" @default.
• W2142940897 type Work @default.
• W2142940897 sameAs 2142940897 @default.
• W2142940897 citedByCount "26" @default.
• W2142940897 countsByYear W21429408972014 @default.
• W2142940897 countsByYear W21429408972015 @default.
• W2142940897 countsByYear W21429408972016 @default.
• W2142940897 countsByYear W21429408972017 @default.
• W2142940897 countsByYear W21429408972018 @default.
• W2142940897 countsByYear W21429408972019 @default.
• W2142940897 countsByYear W21429408972020 @default.
• W2142940897 countsByYear W21429408972021 @default.
• W2142940897 crossrefType "journal-article" @default.
• W2142940897 hasAuthorship W2142940897A5003849228 @default.
• W2142940897 hasAuthorship W2142940897A5005742545 @default.
• W2142940897 hasAuthorship W2142940897A5024581043 @default.
• W2142940897 hasAuthorship W2142940897A5029979171 @default.
• W2142940897 hasAuthorship W2142940897A5030727982 @default.
• W2142940897 hasAuthorship W2142940897A5031318111 @default.
• W2142940897 hasAuthorship W2142940897A5036722309 @default.
• W2142940897 hasAuthorship W2142940897A5040337685 @default.
• W2142940897 hasAuthorship W2142940897A5042428837 @default.
• W2142940897 hasAuthorship W2142940897A5043267123 @default.
• W2142940897 hasAuthorship W2142940897A5043361043 @default.
• W2142940897 hasAuthorship W2142940897A5047024835 @default.
• W2142940897 hasAuthorship W2142940897A5050453569 @default.
• W2142940897 hasAuthorship W2142940897A5054344555 @default.
• W2142940897 hasAuthorship W2142940897A5062631592 @default.
• W2142940897 hasAuthorship W2142940897A5067800806 @default.
• W2142940897 hasAuthorship W2142940897A5078194642 @default.
• W2142940897 hasBestOaLocation W21429408971 @default.

• next