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• W2142943268 startingPage "23" @default.
• W2142943268 abstract "▪ Abstract Several members of the tumor necrosis factor receptor (TNFR) family function after initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB (CD137), OX40 (CD134), HVEM, CD30, and GITR, all of which can have costimulatory effects on T cells. The effects of these costimulatory TNFR family members can often be functionally, temporally, or spatially segregated from those of CD28 and from each other. The sequential and transient regulation of T cell activation/survival signals by different costimulators may function to allow longevity of the response while maintaining tight control of T cell survival. Depending on the disease condition, stimulation via costimulatory TNF family members can exacerbate or ameliorate disease. Despite these complexities, stimulation or blockade of TNFR family costimulators shows promise for several therapeutic applications, including cancer, infectious disease, transplantation, and autoimmunity." @default.
• W2142943268 created "2016-06-24" @default.
• W2142943268 creator A5046685448 @default.
• W2142943268 date "2005-04-01" @default.
• W2142943268 modified "2023-10-11" @default.
• W2142943268 title "TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES" @default.
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