Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143004627> ?p ?o ?g. }
- W2143004627 endingPage "512S" @default.
- W2143004627 startingPage "483S" @default.
- W2143004627 abstract "This chapter about treatment and prevention of stroke is part of the 7th ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that individual patients' values may lead to different choices (for a full understanding of the grading see Guyatt et al). Among the key recommendations in this chapter are the following: For patients with acute ischemic stroke (AIS), we recommend administration of i.v. tissue plasminogen activator (tPA), if treatment is initiated within 3 h of clearly defined symptom onset (Grade 1A). For patients with extensive and clearly identifiable hypodensity on CT, we recommend against thrombolytic therapy (Grade 1B). For unselected patients with AIS of > 3 h but < 6 h, we suggest clinicians not use i.v. tPA (Grade 2A). For patients with AIS, we recommend against streptokinase (Grade 1A) and suggest clinicians not use full-dose anticoagulation with i.v. or subcutaneous heparins or heparinoids (Grade 2B). For patients with AIS who are not receiving thrombolysis, we recommend early aspirin therapy, 160 to 325 mg qd (Grade 1A). For AIS patients with restricted mobility, we recommend prophylactic low-dose subcutaneous heparin or low molecular weight heparins or heparinoids (Grade 1A); and for patients who have contraindications to anticoagulants, we recommend use of intermittent pneumatic compression devices or elastic stockings (Grade 1C). In patients with acute intracerebral hematoma, we recommend the initial use of intermittent pneumatic compression (Grade 1C+). In patients with noncardioembolic stroke or transient ischemic attack (TIA) [ie, atherothrombotic, lacunar or cryptogenic], we recommend treatment with an antiplatelet agent (Grade 1A) including aspirin, 50 to 325 mg qd; the combination of aspirin and extended-release dipyridamole, 25 mg/200 mg bid; or clopidogrel, 75 mg qd. In these patients, we suggest use of the combination of aspirin and extended-release dipyridamole, 25/200 mg bid, over aspirin (Grade 2A) and clopidogrel over aspirin (Grade 2B). For patients who are allergic to aspirin, we recommend clopidogrel (Grade 1C+). In patients with atrial fibrillation and a recent stroke or TIA, we recommend long-term oral anticoagulation (target international normalized ratio, 2.5; range, 2.0 to 3.0) [Grade 1A]. In patients with venous sinus thrombosis, we recommend unfractionated heparin (Grade 1B) or low molecular weight heparin (Grade 1B) over no anticoagulant therapy during the acute phase." @default.
- W2143004627 created "2016-06-24" @default.
- W2143004627 creator A5011832099 @default.
- W2143004627 creator A5016216017 @default.
- W2143004627 creator A5023091399 @default.
- W2143004627 creator A5024460519 @default.
- W2143004627 creator A5040093844 @default.
- W2143004627 date "2004-09-01" @default.
- W2143004627 modified "2023-10-09" @default.
- W2143004627 title "Antithrombotic and Thrombolytic Therapy for Ischemic Stroke" @default.
- W2143004627 cites W10734288 @default.
- W2143004627 cites W1493823773 @default.
- W2143004627 cites W1522694313 @default.
- W2143004627 cites W1637796143 @default.
- W2143004627 cites W1823696497 @default.
- W2143004627 cites W1863866173 @default.
- W2143004627 cites W1963727124 @default.
- W2143004627 cites W1966175035 @default.
- W2143004627 cites W1966306892 @default.
- W2143004627 cites W1969329435 @default.
- W2143004627 cites W1969533355 @default.
- W2143004627 cites W1970272232 @default.
- W2143004627 cites W1972187733 @default.
- W2143004627 cites W1974638135 @default.
- W2143004627 cites W1974992620 @default.
- W2143004627 cites W1975186830 @default.
- W2143004627 cites W1976237679 @default.
- W2143004627 cites W1976776693 @default.
- W2143004627 cites W1977057099 @default.
- W2143004627 cites W1977453416 @default.
- W2143004627 cites W1979346069 @default.
- W2143004627 cites W1980996793 @default.
- W2143004627 cites W1987341486 @default.
- W2143004627 cites W1988169277 @default.
- W2143004627 cites W1989935089 @default.
- W2143004627 cites W1990038916 @default.
- W2143004627 cites W1990624938 @default.
- W2143004627 cites W1991549653 @default.
- W2143004627 cites W1993371786 @default.
- W2143004627 cites W1994445887 @default.
- W2143004627 cites W1994580388 @default.
- W2143004627 cites W1998257407 @default.
- W2143004627 cites W1998421545 @default.
- W2143004627 cites W1998971444 @default.
- W2143004627 cites W2002615573 @default.
- W2143004627 cites W2004045567 @default.
- W2143004627 cites W2005882777 @default.
- W2143004627 cites W2007675941 @default.
- W2143004627 cites W2008312065 @default.
- W2143004627 cites W2010050468 @default.
- W2143004627 cites W2014757808 @default.
- W2143004627 cites W2016989041 @default.
- W2143004627 cites W2020321346 @default.
- W2143004627 cites W2021265694 @default.
- W2143004627 cites W2021374170 @default.
- W2143004627 cites W2021463269 @default.
- W2143004627 cites W2021556603 @default.
- W2143004627 cites W2022849158 @default.
- W2143004627 cites W2024352468 @default.
- W2143004627 cites W2024599316 @default.
- W2143004627 cites W2025314823 @default.
- W2143004627 cites W2027538725 @default.
- W2143004627 cites W2031702150 @default.
- W2143004627 cites W2031990245 @default.
- W2143004627 cites W2032261381 @default.
- W2143004627 cites W2034701398 @default.
- W2143004627 cites W2035656335 @default.
- W2143004627 cites W2036235793 @default.
- W2143004627 cites W2036691135 @default.
- W2143004627 cites W2037268923 @default.
- W2143004627 cites W2040120906 @default.
- W2143004627 cites W2040842434 @default.
- W2143004627 cites W2041966712 @default.
- W2143004627 cites W2043045498 @default.
- W2143004627 cites W2044751523 @default.
- W2143004627 cites W2044891648 @default.
- W2143004627 cites W2046491923 @default.
- W2143004627 cites W2048614158 @default.
- W2143004627 cites W2050461490 @default.
- W2143004627 cites W2053379248 @default.
- W2143004627 cites W2054213128 @default.
- W2143004627 cites W205495280 @default.
- W2143004627 cites W2059231500 @default.
- W2143004627 cites W2060282054 @default.
- W2143004627 cites W2060946128 @default.
- W2143004627 cites W2061599477 @default.
- W2143004627 cites W2063521061 @default.
- W2143004627 cites W2065063783 @default.
- W2143004627 cites W2066775145 @default.
- W2143004627 cites W2066931969 @default.
- W2143004627 cites W2068059485 @default.
- W2143004627 cites W2068246574 @default.
- W2143004627 cites W2071984852 @default.
- W2143004627 cites W2078016815 @default.
- W2143004627 cites W2079018370 @default.
- W2143004627 cites W2079798615 @default.
- W2143004627 cites W2084818579 @default.
- W2143004627 cites W2085195775 @default.