FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143006477> ?p ?o ?g. }

• W2143006477 endingPage "1264" @default.
• W2143006477 startingPage "1252" @default.
• W2143006477 abstract "Background: Adolescent alcohol use may contribute to long‐term changes in the receptors and neuroactive steroids that may mediate its effects and to subsequent alcohol abuse and dependence as an adult. Therefore, in this study, ethanol preference and intake as an adult were examined after adolescent ethanol or saline administration. In addition, ethanol intake in the same groups was examined after administration of 2 neuroactive steroids with modulatory effects at GABA A receptors. Methods: Two groups of male Long‐Evans rats were administered 15 intraperitoneal (i.p.) injections of either ethanol (2 g/kg, 20% v/v) or saline between postnatal days 35 and 63. Starting on postnatal day 75, both groups were trained to consume 10% ethanol using a saccharin‐fading procedure, and ethanol intake and preference were measured after a series of manipulations involving food deprivation, changes in the duration of access to ethanol, and changes in the concentrations of ethanol presented. Following these manipulations, pregnanolone (1 to 10 mg/kg) and dehydroepiandrosterone (DHEA, 1 to 100 mg/kg) were administered prior to preference sessions with an 18% ethanol solution. Results: Adult ethanol preference and intake did not differ significantly in subjects treated with either saline or ethanol as adolescents during training, the substitution of other ethanol concentrations (3.2 to 32%), ad‐lib feeding, or moderate food deprivation. Pregnanolone administration altered the intake of both adolescent‐treated groups after the first injection of 3.2 mg/kg and after repeated injections with 10 mg/kg, a dose that produced sedation. In contrast, multiple doses of DHEA consistently decreased intake of an 18% ethanol concentration in both groups after repeated injections and 3 doses of DHEA (10, 32, and 56 mg/kg) administered with various ethanol concentrations dose‐dependently shifted the ethanol‐concentration curves for the volume and dosage of ethanol consumed downward. Conclusions: These results indicate that chronic intermittent ethanol (CIE) administration of 2 g/kg during adolescence did not alter preference or overall consumption of ethanol in outbred rats trained to drink ethanol as an adult under the conditions tested, and that DHEA may be more effective than pregnanolone at significantly decreasing ethanol consumption." @default.
• W2143006477 created "2016-06-24" @default.
• W2143006477 creator A5028033990 @default.
• W2143006477 creator A5042374539 @default.
• W2143006477 creator A5049074011 @default.
• W2143006477 creator A5049339126 @default.
• W2143006477 date "2009-06-22" @default.
• W2143006477 modified "2023-10-16" @default.
• W2143006477 title "Effects of Pregnanolone and Dehydroepiandrosterone on Ethanol Intake in Rats Administered Ethanol or Saline during Adolescence" @default.
• W2143006477 cites W1501604912 @default.
• W2143006477 cites W1922154348 @default.
• W2143006477 cites W1965043481 @default.
• W2143006477 cites W1966722313 @default.
• W2143006477 cites W1968678284 @default.
• W2143006477 cites W1969106801 @default.
• W2143006477 cites W1972991560 @default.
• W2143006477 cites W1976019710 @default.
• W2143006477 cites W1980844720 @default.
• W2143006477 cites W1982615438 @default.
• W2143006477 cites W1992098768 @default.
• W2143006477 cites W1992325050 @default.
• W2143006477 cites W1993202660 @default.
• W2143006477 cites W2008488411 @default.
• W2143006477 cites W2008920256 @default.
• W2143006477 cites W2011961236 @default.
• W2143006477 cites W2012699847 @default.
• W2143006477 cites W2015269938 @default.
• W2143006477 cites W2019452769 @default.
• W2143006477 cites W2022253572 @default.
• W2143006477 cites W2025068945 @default.
• W2143006477 cites W2025167609 @default.
• W2143006477 cites W2028292251 @default.
• W2143006477 cites W2028466691 @default.
• W2143006477 cites W2028650350 @default.
• W2143006477 cites W2029715805 @default.
• W2143006477 cites W2031351244 @default.
• W2143006477 cites W2031458111 @default.
• W2143006477 cites W2032900150 @default.
• W2143006477 cites W2034351075 @default.
• W2143006477 cites W2035181705 @default.
• W2143006477 cites W2039759850 @default.
• W2143006477 cites W2040701516 @default.
• W2143006477 cites W2051006517 @default.
• W2143006477 cites W2053386267 @default.
• W2143006477 cites W2054579920 @default.
• W2143006477 cites W2059651110 @default.
• W2143006477 cites W2059819618 @default.
• W2143006477 cites W2061979625 @default.
• W2143006477 cites W2067260885 @default.
• W2143006477 cites W2067332258 @default.
• W2143006477 cites W2073278605 @default.
• W2143006477 cites W2076419984 @default.
• W2143006477 cites W2080245295 @default.
• W2143006477 cites W2087419062 @default.
• W2143006477 cites W2087459950 @default.
• W2143006477 cites W2113893197 @default.
• W2143006477 cites W2118773914 @default.
• W2143006477 cites W2121603624 @default.
• W2143006477 cites W2141498968 @default.
• W2143006477 cites W2164079620 @default.
• W2143006477 cites W4238516327 @default.
• W2143006477 cites W4245117662 @default.
• W2143006477 cites W4298239848 @default.
• W2143006477 doi "https://doi.org/10.1111/j.1530-0277.2009.00951.x" @default.
• W2143006477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2954628" @default.
• W2143006477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19389187" @default.
• W2143006477 hasPublicationYear "2009" @default.
• W2143006477 type Work @default.
• W2143006477 sameAs 2143006477 @default.
• W2143006477 citedByCount "17" @default.
• W2143006477 countsByYear W21430064772012 @default.
• W2143006477 countsByYear W21430064772013 @default.
• W2143006477 countsByYear W21430064772015 @default.
• W2143006477 countsByYear W21430064772016 @default.
• W2143006477 countsByYear W21430064772017 @default.
• W2143006477 countsByYear W21430064772019 @default.
• W2143006477 countsByYear W21430064772022 @default.
• W2143006477 crossrefType "journal-article" @default.
• W2143006477 hasAuthorship W2143006477A5028033990 @default.
• W2143006477 hasAuthorship W2143006477A5042374539 @default.
• W2143006477 hasAuthorship W2143006477A5049074011 @default.
• W2143006477 hasAuthorship W2143006477A5049339126 @default.
• W2143006477 hasBestOaLocation W21430064772 @default.
• W2143006477 hasConcept C126322002 @default.
• W2143006477 hasConcept C134018914 @default.
• W2143006477 hasConcept C168258287 @default.
• W2143006477 hasConcept C170493617 @default.
• W2143006477 hasConcept C185592680 @default.
• W2143006477 hasConcept C2776801781 @default.
• W2143006477 hasConcept C2777397205 @default.
• W2143006477 hasConcept C2778555786 @default.
• W2143006477 hasConcept C2779147919 @default.
• W2143006477 hasConcept C2780161600 @default.
• W2143006477 hasConcept C2781066024 @default.
• W2143006477 hasConcept C44796713 @default.
• W2143006477 hasConcept C55493867 @default.
• W2143006477 hasConcept C71924100 @default.
• W2143006477 hasConceptScore W2143006477C126322002 @default.

• next