Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143010405> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2143010405 endingPage "1856" @default.
- W2143010405 startingPage "1850" @default.
- W2143010405 abstract "The heavy-chain switch from immunoglobulin M (IgM) expression to IgA expression is mediated by a recombination event between segments of DNA called switch regions. The switch regions lie two to six kilobases upstream of the mu and alpha constant region coding segments. Switch recombination to IgA expression results in a recombinant mu-alpha switch region upstream of the expressed alpha constant region gene. We have characterized the products of switch recombination by a lymphoma cell line, I.29. Two sets of molecular clones represent the expected products of simple mu to alpha switches. Five members of a third set of molecular clones share the same recombination site in both the mu and the alpha switch regions, implying that the five molecular clones were derived from a single switch recombination event. Surprisingly, the five clones fall into two sets of sequences, which differ from each other by several point mutations and small deletions. Duplication of switch region sequences are also found in these five molecular clones. An explanation for these data is that switch recombination involves DNA synthesis, which results in nucleotide substitutions, small deletions, and duplications." @default.
- W2143010405 created "2016-06-24" @default.
- W2143010405 creator A5026011921 @default.
- W2143010405 creator A5037190623 @default.
- W2143010405 creator A5049119519 @default.
- W2143010405 date "1989-05-01" @default.
- W2143010405 modified "2023-10-17" @default.
- W2143010405 title "Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch." @default.
- W2143010405 cites W1547849676 @default.
- W2143010405 cites W1564184881 @default.
- W2143010405 cites W1586326225 @default.
- W2143010405 cites W1586544157 @default.
- W2143010405 cites W1887595514 @default.
- W2143010405 cites W1955998743 @default.
- W2143010405 cites W1992967316 @default.
- W2143010405 cites W1993481775 @default.
- W2143010405 cites W1993884661 @default.
- W2143010405 cites W1994589394 @default.
- W2143010405 cites W2005021967 @default.
- W2143010405 cites W2007647936 @default.
- W2143010405 cites W2010130789 @default.
- W2143010405 cites W2026091879 @default.
- W2143010405 cites W2054468433 @default.
- W2143010405 cites W2055554809 @default.
- W2143010405 cites W2055879678 @default.
- W2143010405 cites W2061842844 @default.
- W2143010405 cites W2076327247 @default.
- W2143010405 cites W2085369521 @default.
- W2143010405 cites W2087406714 @default.
- W2143010405 cites W2091810736 @default.
- W2143010405 cites W2200046161 @default.
- W2143010405 cites W2343411522 @default.
- W2143010405 cites W2109530551 @default.
- W2143010405 doi "https://doi.org/10.1128/mcb.9.5.1850" @default.
- W2143010405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/362975" @default.
- W2143010405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2747637" @default.
- W2143010405 hasPublicationYear "1989" @default.
- W2143010405 type Work @default.
- W2143010405 sameAs 2143010405 @default.
- W2143010405 citedByCount "78" @default.
- W2143010405 countsByYear W21430104052014 @default.
- W2143010405 crossrefType "journal-article" @default.
- W2143010405 hasAuthorship W2143010405A5026011921 @default.
- W2143010405 hasAuthorship W2143010405A5037190623 @default.
- W2143010405 hasAuthorship W2143010405A5049119519 @default.
- W2143010405 hasBestOaLocation W21430104051 @default.
- W2143010405 hasConcept C104317684 @default.
- W2143010405 hasConcept C137756551 @default.
- W2143010405 hasConcept C153911025 @default.
- W2143010405 hasConcept C156695909 @default.
- W2143010405 hasConcept C159654299 @default.
- W2143010405 hasConcept C2778453870 @default.
- W2143010405 hasConcept C2780254951 @default.
- W2143010405 hasConcept C2992511266 @default.
- W2143010405 hasConcept C40767141 @default.
- W2143010405 hasConcept C54355233 @default.
- W2143010405 hasConcept C552990157 @default.
- W2143010405 hasConcept C7602840 @default.
- W2143010405 hasConcept C86803240 @default.
- W2143010405 hasConcept C91779695 @default.
- W2143010405 hasConcept C96007430 @default.
- W2143010405 hasConceptScore W2143010405C104317684 @default.
- W2143010405 hasConceptScore W2143010405C137756551 @default.
- W2143010405 hasConceptScore W2143010405C153911025 @default.
- W2143010405 hasConceptScore W2143010405C156695909 @default.
- W2143010405 hasConceptScore W2143010405C159654299 @default.
- W2143010405 hasConceptScore W2143010405C2778453870 @default.
- W2143010405 hasConceptScore W2143010405C2780254951 @default.
- W2143010405 hasConceptScore W2143010405C2992511266 @default.
- W2143010405 hasConceptScore W2143010405C40767141 @default.
- W2143010405 hasConceptScore W2143010405C54355233 @default.
- W2143010405 hasConceptScore W2143010405C552990157 @default.
- W2143010405 hasConceptScore W2143010405C7602840 @default.
- W2143010405 hasConceptScore W2143010405C86803240 @default.
- W2143010405 hasConceptScore W2143010405C91779695 @default.
- W2143010405 hasConceptScore W2143010405C96007430 @default.
- W2143010405 hasIssue "5" @default.
- W2143010405 hasLocation W21430104051 @default.
- W2143010405 hasLocation W21430104052 @default.
- W2143010405 hasLocation W21430104053 @default.
- W2143010405 hasOpenAccess W2143010405 @default.
- W2143010405 hasPrimaryLocation W21430104051 @default.
- W2143010405 hasRelatedWork W154036072 @default.
- W2143010405 hasRelatedWork W1575171972 @default.
- W2143010405 hasRelatedWork W1997250840 @default.
- W2143010405 hasRelatedWork W2004092769 @default.
- W2143010405 hasRelatedWork W2074141999 @default.
- W2143010405 hasRelatedWork W2143010405 @default.
- W2143010405 hasRelatedWork W2162732485 @default.
- W2143010405 hasRelatedWork W2343411522 @default.
- W2143010405 hasRelatedWork W4232787820 @default.
- W2143010405 hasRelatedWork W4239862408 @default.
- W2143010405 hasVolume "9" @default.
- W2143010405 isParatext "false" @default.
- W2143010405 isRetracted "false" @default.
- W2143010405 magId "2143010405" @default.
- W2143010405 workType "article" @default.