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- W2143011469 abstract "With the development of effective therapies against HIV, chronic HCV infection has become a major cause of morbidity and mortality among patients harboring both infections. Therefore, fibrosis stage assessment and consideration of HCV treatment options is of utmost importance in this particular patient group. Over the last years, treatment with pegylated interferon (IFN) plus ribavirin (RBV) has been recommended for co-infected patients who are at the greatest risk for liver disease progression, however, despite acceptable response rates for HCV genotype 2 and 3 patients, the effectiveness of HCV treatment in the widespread genotype 1 and 4 patients has been disappointing. Therefore, the development of direct acting antivirals for treatment of HCV has been eagerly awaited to hopefully improve HCV treatment outcome in coinfected individuals. The first SVR12 week results from pilot trials with either boceprevir or telaprevir in HCV treatment-naive GT 1 patients with HIV coinfection with over 30% higher cure rates than under traditional PEG-IFN/RBV therapy have started to change the gold standard of treating hepatitis C. Nevertheless, numerous challenges remain including choice of patients to treat, potential for drug-drug interactions and overlapping toxicities between HIV and HCV therapy. Although treatment of the HIV/HCV coinfected patients remains difficult and contains considerable clinical and economic challenges, drastically improved cure rates of HCV under new triple therapy warrant evaluation of these new treatment options for all coinfected patients." @default.
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- W2143011469 date "2012-06-01" @default.
- W2143011469 modified "2023-09-30" @default.
- W2143011469 title "Management of hepatitis C in HIV-coinfected patients" @default.
- W2143011469 doi "https://doi.org/10.1016/j.ijid.2012.05.085" @default.
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