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• W2143043708 abstract "Our recent study found that 30% of young genes were essential for viability that determines development through stages from embryo to pupae in Drosophila melanogaster, revealing rapidly evolving genetic components involved in the evolution of development. Meanwhile, many young genes did not produce complete lethal phenotype upon constitutive knockdown, suggesting that they may not be essential for viability. These genes, nevertheless, were fixed by natural selection, and might play an important functional role in their adult stage. Here we present a detailed demonstration that a newly duplicated serine-type endopeptidase gene that originated in the common ancestor in the D. melanogaster subgroup 6~11 million years ago, named Slfc, revealing a strong effect in post-eclosion. Although animals survived constitutive knockdown of Slfc to adult stage, however, their life span reduced significantly by two-thirds compared to wildtype. Furthermore, the Slfc-RNAi males dropped their fertility to less than 10% of the wildtype level, with over 80% of these males being sterile. The Slfc-RNAi females, on the other hand, showed a slight reduction in fertility. This case study demonstrates that a young gene can contribute to fitness on the three important traits of life history in adults, including the life expectancy, male fertility and female fertility, suggesting that new genes can quickly evolve and impact multiple phenotypes." @default.
• W2143043708 created "2016-06-24" @default.
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• W2143043708 date "2011-10-01" @default.
• W2143043708 modified "2023-09-23" @default.
• W2143043708 title "Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages" @default.
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• W2143043708 doi "https://doi.org/10.4161/fly.5.4.17808" @default.
• W2143043708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3266076" @default.
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