Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143048167> ?p ?o ?g. }
- W2143048167 endingPage "56" @default.
- W2143048167 startingPage "49" @default.
- W2143048167 abstract "Endometriosis is a common, chronic and estrogen-dependent gynaecological disorder associated with pelvic pain and infertility. In addition to, or perhaps as a consequence of, immune, environmental and genetic factors, endometriotic lesions show high estradiol (E2) biosynthesis and low E2 inactivation compared with normal endometrium. Current medical therapies of pain, which aim to lower circulating E2 concentrations, are not effective in at least half of these patients. We and others recently demonstrated the expression of a few steroidogenic genes in endometriosis. The most important genes in this group are steroidogenic acute regulatory protein (StAR) and aromatase. Both are essential for E2 production. Prostaglandin E2 (PGE2) is the most potent known stimulator of both StAR and aromatase. PGE2 production in endometriosis is up-regulated by increased levels of the enzyme cyclo-oxygenase-2 (COX-2) in this tissue. COX-2 in turn is stimulated by E2, interleukin-1β (IL-1β) and PGE2 itself in endometrial and endometriotic cells. Thus, there is a positive feedback loop that favours continuous formation of E2 and PGE2 in endometriosis. These basic findings led to recent phase-II studies employing aromatase inhibitors in the treatment of endometriosis. Aromatase inhibitors treat both postmenopausal and premenopausal endometriosis at least as effectively as the existing medical treatments. In premenopausal women, we and others administered aromatase inhibitors in combination with an ovarian-suppressant treatment. In this review, we emphasize the most recent basic studies in detail and provide a short summary of recent clinical trials." @default.
- W2143048167 created "2016-06-24" @default.
- W2143048167 creator A5009298625 @default.
- W2143048167 creator A5011124925 @default.
- W2143048167 date "2005-08-25" @default.
- W2143048167 modified "2023-10-17" @default.
- W2143048167 title "Aromatase and other steroidogenic genes in endometriosis: translational aspects" @default.
- W2143048167 cites W1547162940 @default.
- W2143048167 cites W1967641836 @default.
- W2143048167 cites W1977137328 @default.
- W2143048167 cites W1982071620 @default.
- W2143048167 cites W1988495226 @default.
- W2143048167 cites W1996146878 @default.
- W2143048167 cites W1999582107 @default.
- W2143048167 cites W2017521059 @default.
- W2143048167 cites W2027541335 @default.
- W2143048167 cites W2029530915 @default.
- W2143048167 cites W2033387004 @default.
- W2143048167 cites W2036801297 @default.
- W2143048167 cites W2047518704 @default.
- W2143048167 cites W2049619918 @default.
- W2143048167 cites W2057939468 @default.
- W2143048167 cites W2066549596 @default.
- W2143048167 cites W2070663522 @default.
- W2143048167 cites W2074063177 @default.
- W2143048167 cites W2075751134 @default.
- W2143048167 cites W2076358748 @default.
- W2143048167 cites W2078740802 @default.
- W2143048167 cites W2086645076 @default.
- W2143048167 cites W2088871668 @default.
- W2143048167 cites W2090793581 @default.
- W2143048167 cites W2092171701 @default.
- W2143048167 cites W2092174240 @default.
- W2143048167 cites W2092547974 @default.
- W2143048167 cites W2092919766 @default.
- W2143048167 cites W2096715492 @default.
- W2143048167 cites W2097155470 @default.
- W2143048167 cites W2097415667 @default.
- W2143048167 cites W2105925637 @default.
- W2143048167 cites W2114257218 @default.
- W2143048167 cites W2121071871 @default.
- W2143048167 cites W2137867018 @default.
- W2143048167 cites W2139493371 @default.
- W2143048167 cites W2143049848 @default.
- W2143048167 cites W2149342667 @default.
- W2143048167 cites W2153979571 @default.
- W2143048167 cites W2154239454 @default.
- W2143048167 cites W2155206661 @default.
- W2143048167 cites W2159803441 @default.
- W2143048167 cites W2162128679 @default.
- W2143048167 cites W2163247678 @default.
- W2143048167 cites W2168240431 @default.
- W2143048167 cites W2170554336 @default.
- W2143048167 cites W2171026981 @default.
- W2143048167 cites W4211081176 @default.
- W2143048167 doi "https://doi.org/10.1093/humupd/dmi034" @default.
- W2143048167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16123052" @default.
- W2143048167 hasPublicationYear "2005" @default.
- W2143048167 type Work @default.
- W2143048167 sameAs 2143048167 @default.
- W2143048167 citedByCount "210" @default.
- W2143048167 countsByYear W21430481672012 @default.
- W2143048167 countsByYear W21430481672013 @default.
- W2143048167 countsByYear W21430481672014 @default.
- W2143048167 countsByYear W21430481672015 @default.
- W2143048167 countsByYear W21430481672016 @default.
- W2143048167 countsByYear W21430481672017 @default.
- W2143048167 countsByYear W21430481672018 @default.
- W2143048167 countsByYear W21430481672019 @default.
- W2143048167 countsByYear W21430481672020 @default.
- W2143048167 countsByYear W21430481672021 @default.
- W2143048167 countsByYear W21430481672022 @default.
- W2143048167 countsByYear W21430481672023 @default.
- W2143048167 crossrefType "journal-article" @default.
- W2143048167 hasAuthorship W2143048167A5009298625 @default.
- W2143048167 hasAuthorship W2143048167A5011124925 @default.
- W2143048167 hasBestOaLocation W21430481671 @default.
- W2143048167 hasConcept C104317684 @default.
- W2143048167 hasConcept C121608353 @default.
- W2143048167 hasConcept C126322002 @default.
- W2143048167 hasConcept C126838900 @default.
- W2143048167 hasConcept C134018914 @default.
- W2143048167 hasConcept C150194340 @default.
- W2143048167 hasConcept C2776166826 @default.
- W2143048167 hasConcept C2777164284 @default.
- W2143048167 hasConcept C2777688143 @default.
- W2143048167 hasConcept C2777956040 @default.
- W2143048167 hasConcept C2779234561 @default.
- W2143048167 hasConcept C2779522080 @default.
- W2143048167 hasConcept C2779670467 @default.
- W2143048167 hasConcept C2780136519 @default.
- W2143048167 hasConcept C530470458 @default.
- W2143048167 hasConcept C54355233 @default.
- W2143048167 hasConcept C55493867 @default.
- W2143048167 hasConcept C71924100 @default.
- W2143048167 hasConcept C86803240 @default.
- W2143048167 hasConceptScore W2143048167C104317684 @default.
- W2143048167 hasConceptScore W2143048167C121608353 @default.