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• W2143057783 abstract "A series of arylpiperazinylbutyl derivatives of 4,5-dihydro-1,2,4-triazine-6(1H)-ones was designed and synthesized according to the new solid-supported methodology. In this approach, triazinone scaffold was constructed from the Fmoc-protected glycine. The library representatives showed different levels of affinity for 5-HT7 and 5-HT1A receptors; compounds 13, 14 and 18-20 were classified as dual 5-HT7 /5-HT1A receptors ligands. The structure-affinity relationship analysis revealed that the receptor affinity and selectivity of the tested compounds depended on the kind of substituent in position 3 of triazinone fragment as well as substitution pattern of the phenylpiperazine moiety." @default.
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• W2143057783 date "2015-03-06" @default.
• W2143057783 modified "2023-10-05" @default.
• W2143057783 title "Solid-Supported Synthesis and 5-HT₇/5-HT_1AReceptor Affinity of Arylpiperazinylbutyl Derivatives of 4,5-dihydro-1,2,4-triazine-6-(1<i>H</i>)-one" @default.
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• W2143057783 doi "https://doi.org/10.1111/cbdd.12539" @default.
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