FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143059075> ?p ?o ?g. }

• W2143059075 endingPage "S84" @default.
• W2143059075 startingPage "S78" @default.
• W2143059075 abstract "Hyperthermia is one of the modalities used to treat various forms of malignancies, including esophageal, stomach, or rectal cancers.The basic mechanism of synergism between hyperthermia and anticancer drugs, as well as the clinical result of hyperthermia for the treatment of gastrointestinal malignancy, was reviewed.Hyperthermia exerts a cytotoxic effect in combination with various mechanisms. Hyperthermia is applied in combination with chemotherapy and/or radiotherapy in the clinical setting. Among the anticancer drugs that are synergistic with hyperthermia is cisplatin, which is prevalent for clinical application. The mechanism of enhanced cytotoxicity of cisplatin includes increased intracellular drug accumulation, increased platinum-DNA adducts, and inhibition of DNA repair. At our institute, hyperthermochemoradiotherapy was conducted as a neoadjuvant therapy for either operative cases or as a palliative therapy for unresectable cases for esophageal and rectal cancers. In both situations, hyperthermochemoradiotherapy showed an excellent benefit in both the control of local recurrence and and in an improvement in patient survival. Regarding gastric cancer, the most popular application of hyperthermia was the intraoperative hyperthermic peritoneal lavage with cisplatin. This treatment modality demonstrated a better control of the disseminated lesion. Regarding the factors that influence thermosensitivity, in vitro experiments demonstrated the heat-shock proteins or tumor suppressor gene p53 to be related to thermosensitivity. In the clinical setting, these factors remain to be firmly established as predictive factors for thermosensitivity.It is evident that hyperthermia was effective in the control of far-advanced gastrointestinal malignancies. When more reliable factors for the prediction of the treatment response can be established, the standard guidelines for the application of hyperthermia can then be made." @default.
• W2143059075 created "2016-06-24" @default.
• W2143059075 creator A5004420462 @default.
• W2143059075 creator A5024742184 @default.
• W2143059075 creator A5038413438 @default.
• W2143059075 creator A5046684935 @default.
• W2143059075 creator A5057146510 @default.
• W2143059075 creator A5067072266 @default.
• W2143059075 date "2002-01-01" @default.
• W2143059075 modified "2023-10-01" @default.
• W2143059075 title "Clinical application of hyperthermia combined with anticancer drugs for the treatment of solid tumors" @default.
• W2143059075 cites W111348958 @default.
• W2143059075 cites W184542112 @default.
• W2143059075 cites W1963762148 @default.
• W2143059075 cites W1965635040 @default.
• W2143059075 cites W1970665505 @default.
• W2143059075 cites W1972181016 @default.
• W2143059075 cites W1973031247 @default.
• W2143059075 cites W1975931206 @default.
• W2143059075 cites W1984823936 @default.
• W2143059075 cites W1988734683 @default.
• W2143059075 cites W1989915457 @default.
• W2143059075 cites W1992298416 @default.
• W2143059075 cites W1992555237 @default.
• W2143059075 cites W2002034086 @default.
• W2143059075 cites W2006165146 @default.
• W2143059075 cites W2009375859 @default.
• W2143059075 cites W2016067084 @default.
• W2143059075 cites W2020007236 @default.
• W2143059075 cites W2028100604 @default.
• W2143059075 cites W2031862630 @default.
• W2143059075 cites W2032739238 @default.
• W2143059075 cites W2032899284 @default.
• W2143059075 cites W2035474885 @default.
• W2143059075 cites W2037577974 @default.
• W2143059075 cites W2037610580 @default.
• W2143059075 cites W2039512519 @default.
• W2143059075 cites W2045759727 @default.
• W2143059075 cites W2047640292 @default.
• W2143059075 cites W2047644580 @default.
• W2143059075 cites W2049841486 @default.
• W2143059075 cites W2057849399 @default.
• W2143059075 cites W2059200584 @default.
• W2143059075 cites W2061353826 @default.
• W2143059075 cites W2064309565 @default.
• W2143059075 cites W2067295287 @default.
• W2143059075 cites W2072001004 @default.
• W2143059075 cites W2072502607 @default.
• W2143059075 cites W2076657524 @default.
• W2143059075 cites W2082543076 @default.
• W2143059075 cites W2085829043 @default.
• W2143059075 cites W2093778278 @default.
• W2143059075 cites W2111858669 @default.
• W2143059075 cites W2125578049 @default.
• W2143059075 cites W2128729627 @default.
• W2143059075 cites W2260203855 @default.
• W2143059075 cites W2313972632 @default.
• W2143059075 cites W4236909101 @default.
• W2143059075 cites W4246340317 @default.
• W2143059075 cites W4255518914 @default.
• W2143059075 cites W4294702914 @default.
• W2143059075 doi "https://doi.org/10.1067/msy.2002.119308" @default.
• W2143059075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11821791" @default.
• W2143059075 hasPublicationYear "2002" @default.
• W2143059075 type Work @default.
• W2143059075 sameAs 2143059075 @default.
• W2143059075 citedByCount "87" @default.
• W2143059075 countsByYear W21430590752012 @default.
• W2143059075 countsByYear W21430590752013 @default.
• W2143059075 countsByYear W21430590752014 @default.
• W2143059075 countsByYear W21430590752015 @default.
• W2143059075 countsByYear W21430590752016 @default.
• W2143059075 countsByYear W21430590752017 @default.
• W2143059075 countsByYear W21430590752018 @default.
• W2143059075 countsByYear W21430590752019 @default.
• W2143059075 countsByYear W21430590752020 @default.
• W2143059075 countsByYear W21430590752021 @default.
• W2143059075 countsByYear W21430590752022 @default.
• W2143059075 countsByYear W21430590752023 @default.
• W2143059075 crossrefType "journal-article" @default.
• W2143059075 hasAuthorship W2143059075A5004420462 @default.
• W2143059075 hasAuthorship W2143059075A5024742184 @default.
• W2143059075 hasAuthorship W2143059075A5038413438 @default.
• W2143059075 hasAuthorship W2143059075A5046684935 @default.
• W2143059075 hasAuthorship W2143059075A5057146510 @default.
• W2143059075 hasAuthorship W2143059075A5067072266 @default.
• W2143059075 hasConcept C121608353 @default.
• W2143059075 hasConcept C126322002 @default.
• W2143059075 hasConcept C142724271 @default.
• W2143059075 hasConcept C143998085 @default.
• W2143059075 hasConcept C2776694085 @default.
• W2143059075 hasConcept C2778239845 @default.
• W2143059075 hasConcept C2779399171 @default.
• W2143059075 hasConcept C2779949491 @default.
• W2143059075 hasConcept C2781451048 @default.
• W2143059075 hasConcept C502942594 @default.
• W2143059075 hasConcept C509974204 @default.
• W2143059075 hasConcept C71924100 @default.

• next