FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143066666> ?p ?o ?g. }

• W2143066666 abstract "Abstract Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors are effective agents in the treatment of metastatic renal cell cancer (mRCC). We here investigated whether inhibition of VEGFR signalin by sunitinib causes changes in plasma proteins associated with tumor endothelium. Forty‐three patients with mRCC received sunitinib 50 mg/day in a 4‐weeks on 2‐weeks off schedule. Sequential plasma samples were obtained before treatment (C1D1), on C1D14, on C1D28, and on C2D1 before start of cycle 2. Plasma levels were assessed for VEGF, soluble vascular cell adhesion molecule‐1 (sVCAM‐1), soluble intercellular cell adhesion molecule‐1 (sICAM‐1), von Willebrand factor (vWF), circulating angiopoietin‐2 (Ang‐2) and soluble Tie‐2 (sTie‐2). Total tumor burden was calculated at baseline and at first evaluation. Progression‐free survival (PFS) and overall survival (OS) were determined. Tumor burden was positively associated with baseline circulating Ang‐2 [Spearman's rho (ρ) = 0.378, p = 0.028] and vWF (ρ = 0.417, p = 0.008). During sunitinib treatment, circulating Ang‐2 and sTie‐2 significantly decreased ( p < 0.001 for both), plasma levels of sVCAM‐1 and VEGF significantly increased ( p = 0.022 and p < 0.001), whereas those of sICAM‐1 and vWF remained stable. These protein changes had recovered on C2D1. The reduction in circulating Ang‐2 levels on C1D28 was positively correlated with the percentage decrease in tumor burden (ρ = 0.605; p = 0.002). Baseline protein levels and subsequent changes were not associated with PFS or OS. In conclusion, sunitinib‐induced changes in Ang‐2, sTie‐2, sVCAM‐1 and VEGF are related to the administration schedule, while reduction in Ang‐2 is also associated with decrease in tumor burden." @default.
• W2143066666 created "2016-06-24" @default.
• W2143066666 creator A5011171028 @default.
• W2143066666 creator A5017136846 @default.
• W2143066666 creator A5026793935 @default.
• W2143066666 creator A5056296378 @default.
• W2143066666 creator A5072068921 @default.
• W2143066666 creator A5077018603 @default.
• W2143066666 creator A5080015946 @default.
• W2143066666 creator A5083354719 @default.
• W2143066666 creator A5088663155 @default.
• W2143066666 date "2011-11-08" @default.
• W2143066666 modified "2023-10-18" @default.
• W2143066666 title "Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancer" @default.
• W2143066666 cites W1963663488 @default.
• W2143066666 cites W1965887187 @default.
• W2143066666 cites W1968014316 @default.
• W2143066666 cites W1973677429 @default.
• W2143066666 cites W1978083619 @default.
• W2143066666 cites W1985712533 @default.
• W2143066666 cites W1993117548 @default.
• W2143066666 cites W1996859043 @default.
• W2143066666 cites W2000975023 @default.
• W2143066666 cites W2004809400 @default.
• W2143066666 cites W2008927478 @default.
• W2143066666 cites W2009331269 @default.
• W2143066666 cites W2012255417 @default.
• W2143066666 cites W2014556778 @default.
• W2143066666 cites W2039893214 @default.
• W2143066666 cites W2042283759 @default.
• W2143066666 cites W2042350316 @default.
• W2143066666 cites W2068562114 @default.
• W2143066666 cites W2087933507 @default.
• W2143066666 cites W2101663915 @default.
• W2143066666 cites W2102055984 @default.
• W2143066666 cites W2107194595 @default.
• W2143066666 cites W2114559468 @default.
• W2143066666 cites W2120555366 @default.
• W2143066666 cites W2122298066 @default.
• W2143066666 cites W2122927195 @default.
• W2143066666 cites W2131868847 @default.
• W2143066666 cites W2132827381 @default.
• W2143066666 cites W2139248078 @default.
• W2143066666 cites W2143782771 @default.
• W2143066666 cites W2147552582 @default.
• W2143066666 cites W2149109717 @default.
• W2143066666 cites W2149456801 @default.
• W2143066666 cites W2150452646 @default.
• W2143066666 cites W2150487692 @default.
• W2143066666 cites W2152215024 @default.
• W2143066666 cites W2153331460 @default.
• W2143066666 cites W2160120519 @default.
• W2143066666 cites W2165330900 @default.
• W2143066666 cites W2329503005 @default.
• W2143066666 cites W4252851641 @default.
• W2143066666 doi "https://doi.org/10.1002/ijc.26456" @default.
• W2143066666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21953673" @default.
• W2143066666 hasPublicationYear "2011" @default.
• W2143066666 type Work @default.
• W2143066666 sameAs 2143066666 @default.
• W2143066666 citedByCount "15" @default.
• W2143066666 countsByYear W21430666662012 @default.
• W2143066666 countsByYear W21430666662014 @default.
• W2143066666 countsByYear W21430666662015 @default.
• W2143066666 countsByYear W21430666662016 @default.
• W2143066666 countsByYear W21430666662018 @default.
• W2143066666 countsByYear W21430666662020 @default.
• W2143066666 countsByYear W21430666662021 @default.
• W2143066666 countsByYear W21430666662023 @default.
• W2143066666 crossrefType "journal-article" @default.
• W2143066666 hasAuthorship W2143066666A5011171028 @default.
• W2143066666 hasAuthorship W2143066666A5017136846 @default.
• W2143066666 hasAuthorship W2143066666A5026793935 @default.
• W2143066666 hasAuthorship W2143066666A5056296378 @default.
• W2143066666 hasAuthorship W2143066666A5072068921 @default.
• W2143066666 hasAuthorship W2143066666A5077018603 @default.
• W2143066666 hasAuthorship W2143066666A5080015946 @default.
• W2143066666 hasAuthorship W2143066666A5083354719 @default.
• W2143066666 hasAuthorship W2143066666A5088663155 @default.
• W2143066666 hasConcept C121608353 @default.
• W2143066666 hasConcept C126322002 @default.
• W2143066666 hasConcept C134018914 @default.
• W2143066666 hasConcept C167734588 @default.
• W2143066666 hasConcept C2776871010 @default.
• W2143066666 hasConcept C2777025900 @default.
• W2143066666 hasConcept C2779184299 @default.
• W2143066666 hasConcept C2779394231 @default.
• W2143066666 hasConcept C2779490328 @default.
• W2143066666 hasConcept C71924100 @default.
• W2143066666 hasConcept C89560881 @default.
• W2143066666 hasConceptScore W2143066666C121608353 @default.
• W2143066666 hasConceptScore W2143066666C126322002 @default.
• W2143066666 hasConceptScore W2143066666C134018914 @default.
• W2143066666 hasConceptScore W2143066666C167734588 @default.
• W2143066666 hasConceptScore W2143066666C2776871010 @default.
• W2143066666 hasConceptScore W2143066666C2777025900 @default.
• W2143066666 hasConceptScore W2143066666C2779184299 @default.
• W2143066666 hasConceptScore W2143066666C2779394231 @default.
• W2143066666 hasConceptScore W2143066666C2779490328 @default.
• W2143066666 hasConceptScore W2143066666C71924100 @default.

• next