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- W2143067718 abstract "Aim: Recent years have seen a drive to improve outcomes for lung cancer patients. A focus point of this drive has been to increase surgical resection rates. However, it is not clear if there is an ‘optimal’ surgical resection rate and increased resection rates should not be at the cost of futile thoracotomies. Many experts and guidelines agree that surgical resection of single station N2 disease is appropriate, whereas multi-station N2 disease is not considered a surgical entity. This retrospective study sought to investigate the rate of multi-station N2 disease from intra-operative lymph node sampling over a three year period when resections rates were significantly increasing. Methods: The University Hospital of South Manchester is a large, regional Lung Cancer and Thoracic Surgery Centre. It is the sole thoracic surgery centre for a large Cancer Network. In this Network, PET and EBUS are widely available for pre-operative staging. Single station N2 disease is managed with upfront surgical resection followed by adjuvant therapy, assuming adequate fitness. Multi-station N2 disease is managed with concurrent chemoradiotherapy. For this study, the pathological reports from all lung cancer resections were reviewed from 01/01/2011 to 31/12/2013. The number of resections, proportion of patients with multi-station N2 disease detected from intra-operative lymph node sampling and the proportion of patients with adequate lymph node sampling were calculated for each calendar year. Results: 986 pathological reports were reviewed. 16 were excluded due to incomplete data. The number of resections per year increased dramatically over the study period; 2011 n = 173, 2012 n = 333, 2013 n = 464. Despite this, the rate of multi-station N2 disease remained stable; 2011 4.6%, 2012 3.6%, 2013 5.4%. Conclusions: Despite dramatic increases in the volume of surgical resections for lung cancer at this regional centre, and in the context of improving adequacy of lymph node sampling year on year, the rate of multi-station N2 disease is remaining low (<5%) and stable. This suggests appropriate pre-operative staging and surgical selection within this Network. Disclosure: All authors have declared no conflicts of interest." @default.
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- W2143067718 date "2015-04-01" @default.
- W2143067718 modified "2023-09-27" @default.
- W2143067718 title "Does a Higher Surgical Resection Rate in Lung Cancer Lead to a Higher Rate of Post-Operative Multi-Station N2 Disease?" @default.
- W2143067718 doi "https://doi.org/10.1093/annonc/mdv048.15" @default.
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