Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143102005> ?p ?o ?g. }
- W2143102005 endingPage "80" @default.
- W2143102005 startingPage "61" @default.
- W2143102005 abstract "Over the past decade, molecular-targeted therapies have been added to cytotoxic and anti-endocrine drugs in the treatment of cancer, with the aim to target the molecular pathways that underlie the carcinogenic process and maintain the cancer phenotype. Success with some of these agents has suggested that identification and validation of the drug target is the starting point for the route of development of active, safe and effective drugs. Main molecular targets used to the development of anticancer drugs are cell surface receptors, signal transduction pathways, gene transcription targets, ubiquitin-proteasome/heat shock proteins and tumour microenvironment components (especially antiangiogenic agents). Here, we review the development of the main molecular targeted non-cytotoxic agents studied in cancer, highlighting lessons derived from the development of these novel drugs and proposing new horizons for the clinical development of molecular-targeted therapies." @default.
- W2143102005 created "2016-06-24" @default.
- W2143102005 creator A5010064853 @default.
- W2143102005 creator A5044285770 @default.
- W2143102005 creator A5053299342 @default.
- W2143102005 creator A5057919192 @default.
- W2143102005 date "2008-02-01" @default.
- W2143102005 modified "2023-10-10" @default.
- W2143102005 title "Molecular-targeted therapies: Lessons from years of clinical development" @default.
- W2143102005 cites W120676909 @default.
- W2143102005 cites W14542710 @default.
- W2143102005 cites W1589853442 @default.
- W2143102005 cites W1591166893 @default.
- W2143102005 cites W1603230122 @default.
- W2143102005 cites W1772131958 @default.
- W2143102005 cites W1873121398 @default.
- W2143102005 cites W1924784781 @default.
- W2143102005 cites W1964321121 @default.
- W2143102005 cites W1964372470 @default.
- W2143102005 cites W1966035396 @default.
- W2143102005 cites W1967494335 @default.
- W2143102005 cites W1967891134 @default.
- W2143102005 cites W1968489542 @default.
- W2143102005 cites W1970476748 @default.
- W2143102005 cites W1971434769 @default.
- W2143102005 cites W1972805469 @default.
- W2143102005 cites W1975131304 @default.
- W2143102005 cites W1975519085 @default.
- W2143102005 cites W1978343328 @default.
- W2143102005 cites W1980575012 @default.
- W2143102005 cites W1980827197 @default.
- W2143102005 cites W1982246723 @default.
- W2143102005 cites W1982729445 @default.
- W2143102005 cites W1984429541 @default.
- W2143102005 cites W1985275612 @default.
- W2143102005 cites W1986388339 @default.
- W2143102005 cites W1987517266 @default.
- W2143102005 cites W1988442083 @default.
- W2143102005 cites W1990015440 @default.
- W2143102005 cites W1991123816 @default.
- W2143102005 cites W1991845461 @default.
- W2143102005 cites W1992184657 @default.
- W2143102005 cites W1992321786 @default.
- W2143102005 cites W1993018776 @default.
- W2143102005 cites W1995811812 @default.
- W2143102005 cites W1995930366 @default.
- W2143102005 cites W1996962669 @default.
- W2143102005 cites W1998635761 @default.
- W2143102005 cites W1999614615 @default.
- W2143102005 cites W1999805805 @default.
- W2143102005 cites W2000000541 @default.
- W2143102005 cites W2000122784 @default.
- W2143102005 cites W2000123112 @default.
- W2143102005 cites W2001258296 @default.
- W2143102005 cites W2001544973 @default.
- W2143102005 cites W2006174096 @default.
- W2143102005 cites W2008618899 @default.
- W2143102005 cites W2009204250 @default.
- W2143102005 cites W2009886857 @default.
- W2143102005 cites W2011474502 @default.
- W2143102005 cites W2014613601 @default.
- W2143102005 cites W2015015957 @default.
- W2143102005 cites W2015136221 @default.
- W2143102005 cites W2016086822 @default.
- W2143102005 cites W2017898416 @default.
- W2143102005 cites W2018348203 @default.
- W2143102005 cites W2019264784 @default.
- W2143102005 cites W2021577923 @default.
- W2143102005 cites W2022285476 @default.
- W2143102005 cites W2028070840 @default.
- W2143102005 cites W2028959752 @default.
- W2143102005 cites W2029080338 @default.
- W2143102005 cites W2030022359 @default.
- W2143102005 cites W2030737594 @default.
- W2143102005 cites W2031547755 @default.
- W2143102005 cites W2034666877 @default.
- W2143102005 cites W2037722366 @default.
- W2143102005 cites W2040257851 @default.
- W2143102005 cites W2043432881 @default.
- W2143102005 cites W2046507292 @default.
- W2143102005 cites W2047467740 @default.
- W2143102005 cites W2049484790 @default.
- W2143102005 cites W2049986428 @default.
- W2143102005 cites W2050317804 @default.
- W2143102005 cites W2051055358 @default.
- W2143102005 cites W2051383707 @default.
- W2143102005 cites W2051626784 @default.
- W2143102005 cites W2054949014 @default.
- W2143102005 cites W2055479791 @default.
- W2143102005 cites W2058451329 @default.
- W2143102005 cites W2061349037 @default.
- W2143102005 cites W2061563172 @default.
- W2143102005 cites W2061773314 @default.
- W2143102005 cites W2061943708 @default.
- W2143102005 cites W2064047613 @default.
- W2143102005 cites W2067055586 @default.
- W2143102005 cites W2068133101 @default.
- W2143102005 cites W2070164024 @default.