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- W2143125825 abstract "The mitotic cell selection technique was used to monitor the effects of various drugs, primarily inhibitors of RNA synthesis, on X-ray-induced G2 delay. Chinese hamster ovary cells located in the cycle prior to about 52 min before division, i.e., prior to the X-ray transition point (X-TP), were delayed for 110-130 min from progression into mitosis (G2 delay) after receiving 100 rad. Cells past this X-TP were unaffected in their progression. However, the addition of actinomycin D (AMD, 2 μg/ml), caffeine (19-194 μg/ml), theophylline (18-180 μg/ml), or cordycepin (5-30 μg/ml) immediately before or after irradiation greatly reduced the G2 delay and shifted the X-TP away from division. The magnitude of this protective effect increased with concentration, with a maximum effect of about 90 min for reduction of G2 delay and about 11 min for shifting the X-TP away from division. Less protective effect was observed from the addition of dimethylsulfoxide (DMSO, $10^{4} mu {rm g}/{rm ml}$ ), ..." @default.
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- W2143125825 date "1978-04-01" @default.
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- W2143125825 title "Comparative Studies of the Effects of Drugs on X-Ray-Induced G2 Delay" @default.
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- W2143125825 doi "https://doi.org/10.2307/3574761" @default.
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