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- W2143141824 abstract "We study genetic switches formed from pairs of mutually repressing operons. The switch stability is characterised by a well defined lifetime which grows sub-exponentially with the number of copies of the most-expressed transcription factor, in the regime accessible by our numerical simulations. The stability can be markedly enhanced by a suitable choice of overlap between the upstream regulatory domains. Our results suggest that robustness against biochemical noise can provide a selection pressure that drives operons, that regulate each other, together in the course of evolution." @default.
- W2143141824 created "2016-06-24" @default.
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- W2143141824 date "2004-03-25" @default.
- W2143141824 modified "2023-09-26" @default.
- W2143141824 title "Enhancement of the Stability of Genetic Switches by Overlapping Upstream Regulatory Domains" @default.
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- W2143141824 doi "https://doi.org/10.1103/physrevlett.92.128101" @default.
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