FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143142494> ?p ?o ?g. }

• W2143142494 endingPage "313" @default.
• W2143142494 startingPage "305" @default.
• W2143142494 abstract "Recent studies indicate that the inflammasome activation plays important roles in the pathogenesis of alcoholic hepatitis (AH). Nod-like receptor protein 3 (NLRP3) is a key component of the macromolecular complex that is so called the inflammasome that triggers caspase 1-dependent maturation of the precursors of IL-1β and IL-18 cytokines. It is also known that the adaptor proteins including apoptosis-associated speck-like protein containing CARD (ASC) and the mitochondrial antiviral signaling protein (MAVS) are necessary for NLRP3-dependent inflammasome function. Steatohepatitis frequently includes Mallory-Denk body (MDB) formation. In the case of alcoholic steatohepatitis, MDB formation occurs in 80% of biopsies (French 1981; French 1981). While previous studies have focused on in vitro cell lines and mouse models, we are the first group to investigate inflammasome activation in AH liver biopsy specimen and correlate it with MDB formation. Expression of NOD1, NLRP3, ASC, NAIP, MAVS, caspase 1, IL-1β, IL-18, and other inflammatory components including IL-6, IL-10, TNF-α, IFN-γ, STAT3, and p65 was measured in three to eight formalin-fixed paraffin-embedded AH specimens and control normal liver specimens by immunofluorescence staining and quantified by immunofluorescence intensity. The specimens were double stained with ubiquitin to demonstrate the relationship between inflammasome activation and MDB formation. MAVS, caspase1, IL-18, and TNF-α showed increases in expression in AH compared to the controls (p<0.05), and NAIP expression markedly increased in AH compared to the controls (p<0.01). There was a trend that levels of NLRP3, ASC, caspase1, IL-18, IL-10, and p65 expression correlated with the number of MDBs found in the same field of measurement (correlation coefficients were between 0.62 and 0.93, p<0.05). Our results demonstrate the activation of the inflammasome in AH and suggest that MDB could be an indicator of the extent of inflammasome activation." @default.
• W2143142494 created "2016-06-24" @default.
• W2143142494 creator A5009698253 @default.
• W2143142494 creator A5033298543 @default.
• W2143142494 creator A5063563196 @default.
• W2143142494 creator A5073384883 @default.
• W2143142494 creator A5077980742 @default.
• W2143142494 date "2014-10-01" @default.
• W2143142494 modified "2023-10-16" @default.
• W2143142494 title "The inflammasome in alcoholic hepatitis: Its relationship with Mallory–Denk body formation" @default.
• W2143142494 cites W1529674879 @default.
• W2143142494 cites W1962242957 @default.
• W2143142494 cites W1975752601 @default.
• W2143142494 cites W1978594804 @default.
• W2143142494 cites W1981077171 @default.
• W2143142494 cites W1983771151 @default.
• W2143142494 cites W1984338631 @default.
• W2143142494 cites W1992683117 @default.
• W2143142494 cites W1997572777 @default.
• W2143142494 cites W2009755744 @default.
• W2143142494 cites W2025199001 @default.
• W2143142494 cites W2047034999 @default.
• W2143142494 cites W2052874989 @default.
• W2143142494 cites W2059997362 @default.
• W2143142494 cites W2065850291 @default.
• W2143142494 cites W2079893663 @default.
• W2143142494 cites W2085525635 @default.
• W2143142494 cites W2086919198 @default.
• W2143142494 cites W2093025818 @default.
• W2143142494 cites W2105409495 @default.
• W2143142494 cites W2116483935 @default.
• W2143142494 cites W2125668696 @default.
• W2143142494 cites W2134735862 @default.
• W2143142494 cites W2134770376 @default.
• W2143142494 cites W2145556247 @default.
• W2143142494 cites W2155538302 @default.
• W2143142494 doi "https://doi.org/10.1016/j.yexmp.2014.08.006" @default.
• W2143142494 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4177273" @default.
• W2143142494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25149528" @default.
• W2143142494 hasPublicationYear "2014" @default.
• W2143142494 type Work @default.
• W2143142494 sameAs 2143142494 @default.
• W2143142494 citedByCount "33" @default.
• W2143142494 countsByYear W21431424942015 @default.
• W2143142494 countsByYear W21431424942016 @default.
• W2143142494 countsByYear W21431424942017 @default.
• W2143142494 countsByYear W21431424942018 @default.
• W2143142494 countsByYear W21431424942019 @default.
• W2143142494 countsByYear W21431424942020 @default.
• W2143142494 countsByYear W21431424942021 @default.
• W2143142494 countsByYear W21431424942022 @default.
• W2143142494 countsByYear W21431424942023 @default.
• W2143142494 crossrefType "journal-article" @default.
• W2143142494 hasAuthorship W2143142494A5009698253 @default.
• W2143142494 hasAuthorship W2143142494A5033298543 @default.
• W2143142494 hasAuthorship W2143142494A5063563196 @default.
• W2143142494 hasAuthorship W2143142494A5073384883 @default.
• W2143142494 hasAuthorship W2143142494A5077980742 @default.
• W2143142494 hasBestOaLocation W21431424942 @default.
• W2143142494 hasConcept C126322002 @default.
• W2143142494 hasConcept C142724271 @default.
• W2143142494 hasConcept C159654299 @default.
• W2143142494 hasConcept C183786373 @default.
• W2143142494 hasConcept C185592680 @default.
• W2143142494 hasConcept C203014093 @default.
• W2143142494 hasConcept C2776914184 @default.
• W2143142494 hasConcept C2777209026 @default.
• W2143142494 hasConcept C2777214474 @default.
• W2143142494 hasConcept C2777575235 @default.
• W2143142494 hasConcept C2778236600 @default.
• W2143142494 hasConcept C2778772119 @default.
• W2143142494 hasConcept C2779134260 @default.
• W2143142494 hasConcept C2779478299 @default.
• W2143142494 hasConcept C2780732942 @default.
• W2143142494 hasConcept C2780942790 @default.
• W2143142494 hasConcept C62478195 @default.
• W2143142494 hasConcept C71924100 @default.
• W2143142494 hasConcept C86803240 @default.
• W2143142494 hasConcept C95444343 @default.
• W2143142494 hasConceptScore W2143142494C126322002 @default.
• W2143142494 hasConceptScore W2143142494C142724271 @default.
• W2143142494 hasConceptScore W2143142494C159654299 @default.
• W2143142494 hasConceptScore W2143142494C183786373 @default.
• W2143142494 hasConceptScore W2143142494C185592680 @default.
• W2143142494 hasConceptScore W2143142494C203014093 @default.
• W2143142494 hasConceptScore W2143142494C2776914184 @default.
• W2143142494 hasConceptScore W2143142494C2777209026 @default.
• W2143142494 hasConceptScore W2143142494C2777214474 @default.
• W2143142494 hasConceptScore W2143142494C2777575235 @default.
• W2143142494 hasConceptScore W2143142494C2778236600 @default.
• W2143142494 hasConceptScore W2143142494C2778772119 @default.
• W2143142494 hasConceptScore W2143142494C2779134260 @default.
• W2143142494 hasConceptScore W2143142494C2779478299 @default.
• W2143142494 hasConceptScore W2143142494C2780732942 @default.
• W2143142494 hasConceptScore W2143142494C2780942790 @default.
• W2143142494 hasConceptScore W2143142494C62478195 @default.
• W2143142494 hasConceptScore W2143142494C71924100 @default.
• W2143142494 hasConceptScore W2143142494C86803240 @default.

• next