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• W2143143206 abstract "Spinal and bulbar muscular atrophy is an X-linked neuromuscular disease caused by an expanded repeat in the androgen receptor gene. The mutant protein is toxic to motor neurons and muscle. The toxicity is ligand-dependent and likely involves aberrant interaction of the mutant androgen receptor with other nuclear factors leading to transcriptional dysregulation. Various therapeutic strategies have been effective in transgenic animal models, and the challenge now is to translate these strategies into safe and effective treatment in patients." @default.
• W2143143206 created "2016-06-24" @default.
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• W2143143206 date "2015-11-07" @default.
• W2143143206 modified "2023-09-24" @default.
• W2143143206 title "Spinal and Bulbar Muscular Atrophy Overview" @default.
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• W2143143206 doi "https://doi.org/10.1007/s12031-015-0674-7" @default.
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