FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143145536> ?p ?o ?g. }

• W2143145536 endingPage "1848" @default.
• W2143145536 startingPage "1840" @default.
• W2143145536 abstract "Chronic hyperglycemia desensitizes beta-cells to glucose. To further define the mechanisms behind desensitization and the role of overstimulation, we tested human pancreatic islets for the effects of long-term elevated glucose levels on cytoplasmic free Ca2+ concentration ([Ca2+]i) and its relationship to overstimulation. Islets were cultured for 48 h with 5.5 or 27 mmol/l glucose. Culture with 27 mmol/l glucose obliterated postculture insulin responses to 27 mmol/l glucose. This desensitization was specific for glucose versus arginine. Desensitization was accompanied by three major [Ca2+]i abnormalities: 1) elevated basal [Ca2+]i, 2) loss of a glucose-induced rise in [Ca2+]i, and 3) perturbations of oscillatory activity with a decrease in glucose-induced slow oscillations (0.2-0.5 min(-1)). Coculture with 0.3 mmol/l diazoxide was performed to probe the role of overstimulation. Neither glucose nor diazoxide affected islet glucose utilization or oxidation. Coculture with diazoxide and 27 mmol/l glucose significantly (P < 0.05) restored postculture insulin responses to glucose and lowered basal [Ca2+]i and normalized glucose-induced oscillatory activity. However, diazoxide completely failed to revive an increase in [Ca2+]i during postculture glucose stimulation. In conclusion, desensitization of glucose-induced insulin secretion in human pancreatic islets is induced in parallel with major glucose-specific [Ca2+]i abnormalities. Overstimulation is an important but not exclusive factor behind [Ca2+]i abnormalities." @default.
• W2143145536 created "2016-06-24" @default.
• W2143145536 creator A5018138160 @default.
• W2143145536 creator A5090090811 @default.
• W2143145536 creator A5090224458 @default.
• W2143145536 date "2000-11-01" @default.
• W2143145536 modified "2023-10-18" @default.
• W2143145536 title "Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation." @default.
• W2143145536 cites W1520363389 @default.
• W2143145536 cites W1553310373 @default.
• W2143145536 cites W1643127595 @default.
• W2143145536 cites W1743153984 @default.
• W2143145536 cites W1811497100 @default.
• W2143145536 cites W1931693263 @default.
• W2143145536 cites W1978598042 @default.
• W2143145536 cites W1979946833 @default.
• W2143145536 cites W1981618191 @default.
• W2143145536 cites W1989762800 @default.
• W2143145536 cites W1993257524 @default.
• W2143145536 cites W2017507665 @default.
• W2143145536 cites W2018431159 @default.
• W2143145536 cites W2027103431 @default.
• W2143145536 cites W2028915160 @default.
• W2143145536 cites W2030718654 @default.
• W2143145536 cites W2043438273 @default.
• W2143145536 cites W2048823629 @default.
• W2143145536 cites W2059559761 @default.
• W2143145536 cites W2074306054 @default.
• W2143145536 cites W2078073869 @default.
• W2143145536 cites W2080908315 @default.
• W2143145536 cites W2085196897 @default.
• W2143145536 cites W2088522673 @default.
• W2143145536 cites W2093478842 @default.
• W2143145536 cites W2095976960 @default.
• W2143145536 cites W2098040797 @default.
• W2143145536 cites W2100968639 @default.
• W2143145536 cites W2108027086 @default.
• W2143145536 cites W2109950184 @default.
• W2143145536 cites W2110741515 @default.
• W2143145536 cites W2113922470 @default.
• W2143145536 cites W2122568821 @default.
• W2143145536 cites W2124300043 @default.
• W2143145536 cites W2124971376 @default.
• W2143145536 cites W2125591445 @default.
• W2143145536 cites W2141260882 @default.
• W2143145536 cites W2144624027 @default.
• W2143145536 cites W2154264779 @default.
• W2143145536 cites W2161257972 @default.
• W2143145536 cites W2172205541 @default.
• W2143145536 cites W2247538616 @default.
• W2143145536 cites W2258866380 @default.
• W2143145536 cites W2411552005 @default.
• W2143145536 cites W2418114041 @default.
• W2143145536 cites W2444191947 @default.
• W2143145536 doi "https://doi.org/10.2337/diabetes.49.11.1840" @default.
• W2143145536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11078450" @default.
• W2143145536 hasPublicationYear "2000" @default.
• W2143145536 type Work @default.
• W2143145536 sameAs 2143145536 @default.
• W2143145536 citedByCount "66" @default.
• W2143145536 countsByYear W21431455362012 @default.
• W2143145536 countsByYear W21431455362013 @default.
• W2143145536 countsByYear W21431455362014 @default.
• W2143145536 countsByYear W21431455362015 @default.
• W2143145536 countsByYear W21431455362016 @default.
• W2143145536 countsByYear W21431455362017 @default.
• W2143145536 countsByYear W21431455362018 @default.
• W2143145536 countsByYear W21431455362019 @default.
• W2143145536 countsByYear W21431455362020 @default.
• W2143145536 countsByYear W21431455362021 @default.
• W2143145536 countsByYear W21431455362022 @default.
• W2143145536 crossrefType "journal-article" @default.
• W2143145536 hasAuthorship W2143145536A5018138160 @default.
• W2143145536 hasAuthorship W2143145536A5090090811 @default.
• W2143145536 hasAuthorship W2143145536A5090224458 @default.
• W2143145536 hasBestOaLocation W21431455361 @default.
• W2143145536 hasConcept C126322002 @default.
• W2143145536 hasConcept C134018914 @default.
• W2143145536 hasConcept C165220095 @default.
• W2143145536 hasConcept C170493617 @default.
• W2143145536 hasConcept C17093226 @default.
• W2143145536 hasConcept C185592680 @default.
• W2143145536 hasConcept C24998067 @default.
• W2143145536 hasConcept C2778024521 @default.
• W2143145536 hasConcept C2779306644 @default.
• W2143145536 hasConcept C2779779143 @default.
• W2143145536 hasConcept C2779855799 @default.
• W2143145536 hasConcept C2779872217 @default.
• W2143145536 hasConcept C2780963292 @default.
• W2143145536 hasConcept C71924100 @default.
• W2143145536 hasConcept C86803240 @default.
• W2143145536 hasConceptScore W2143145536C126322002 @default.
• W2143145536 hasConceptScore W2143145536C134018914 @default.
• W2143145536 hasConceptScore W2143145536C165220095 @default.
• W2143145536 hasConceptScore W2143145536C170493617 @default.
• W2143145536 hasConceptScore W2143145536C17093226 @default.
• W2143145536 hasConceptScore W2143145536C185592680 @default.
• W2143145536 hasConceptScore W2143145536C24998067 @default.

• next