FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143149828> ?p ?o ?g. }

• W2143149828 endingPage "1745" @default.
• W2143149828 startingPage "1735" @default.
• W2143149828 abstract "Thyroid hormone (TH) is essential for brain development both before and after birth. We have used gene expression microarrays to identify TH-regulated genes in the fetal cerebral cortex prior to the onset of fetal thyroid function to better understand the role of TH in early cortical development. TH levels were transiently manipulated in pregnant mice by treatment with goitrogens from gestational day (GD) 13–16 and/or by injection of TH 12 h before sacrifice on GD 16. The transcriptional response to exogenous TH in the GD 16 fetal cortex was potentiated by transient goitrogen treatment, suggesting that the hypothyroxinemic brain is a different substrate upon which TH can act, or that robust compensatory mechanisms are induced by transient hypothyroxinemia. Several known TH-responsive genes were identified including Klf9, and several novel TH-responsive genes such as Appbp2, Ppap2b, and Fgfr1op2 were identified in which TH response elements were confirmed. We also identified specific microRNAs whose expression in the fetal cortex was affected by TH treatment, and determined that Ppap2b and Klf9 are the target genes of miR-16 and miR-106, respectively. Thus, a complex redundant functional network appears to coordinate TH-mediated gene expression in the developing brain." @default.
• W2143149828 created "2016-06-24" @default.
• W2143149828 creator A5005738758 @default.
• W2143149828 creator A5033224676 @default.
• W2143149828 creator A5037307065 @default.
• W2143149828 creator A5044032784 @default.
• W2143149828 creator A5077375577 @default.
• W2143149828 creator A5077633544 @default.
• W2143149828 date "2014-01-15" @default.
• W2143149828 modified "2023-09-27" @default.
• W2143149828 title "Transient Maternal Hypothyroxinemia Potentiates the Transcriptional Response to Exogenous Thyroid Hormone in the Fetal Cerebral Cortex Before the Onset of Fetal Thyroid Function: A Messenger and MicroRNA Profiling Study" @default.
• W2143149828 cites W1703087551 @default.
• W2143149828 cites W1970408357 @default.
• W2143149828 cites W1977537973 @default.
• W2143149828 cites W1979030149 @default.
• W2143149828 cites W1981041844 @default.
• W2143149828 cites W1989898590 @default.
• W2143149828 cites W1990329100 @default.
• W2143149828 cites W1990868443 @default.
• W2143149828 cites W1993211925 @default.
• W2143149828 cites W1997413633 @default.
• W2143149828 cites W2000741536 @default.
• W2143149828 cites W2004434507 @default.
• W2143149828 cites W2017452540 @default.
• W2143149828 cites W2021462700 @default.
• W2143149828 cites W2024116370 @default.
• W2143149828 cites W2024638894 @default.
• W2143149828 cites W2025660828 @default.
• W2143149828 cites W2028422261 @default.
• W2143149828 cites W2040112071 @default.
• W2143149828 cites W2048245477 @default.
• W2143149828 cites W2052693888 @default.
• W2143149828 cites W2054343633 @default.
• W2143149828 cites W2055272377 @default.
• W2143149828 cites W2060971080 @default.
• W2143149828 cites W2063324861 @default.
• W2143149828 cites W2081921666 @default.
• W2143149828 cites W2082068065 @default.
• W2143149828 cites W2094705166 @default.
• W2143149828 cites W2107277218 @default.
• W2143149828 cites W2108166391 @default.
• W2143149828 cites W2109972881 @default.
• W2143149828 cites W2110891968 @default.
• W2143149828 cites W2111972832 @default.
• W2143149828 cites W2118441730 @default.
• W2143149828 cites W2120865735 @default.
• W2143149828 cites W2124173888 @default.
• W2143149828 cites W2125767999 @default.
• W2143149828 cites W2126358423 @default.
• W2143149828 cites W2130631987 @default.
• W2143149828 cites W2139834510 @default.
• W2143149828 cites W2142343504 @default.
• W2143149828 cites W2145025818 @default.
• W2143149828 cites W2153888636 @default.
• W2143149828 cites W2163491205 @default.
• W2143149828 cites W2169118951 @default.
• W2143149828 cites W2171716250 @default.
• W2143149828 cites W2171987528 @default.
• W2143149828 cites W2329856164 @default.
• W2143149828 cites W3025840970 @default.
• W2143149828 cites W4211165921 @default.
• W2143149828 doi "https://doi.org/10.1093/cercor/bht364" @default.
• W2143149828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24436321" @default.
• W2143149828 hasPublicationYear "2014" @default.
• W2143149828 type Work @default.
• W2143149828 sameAs 2143149828 @default.
• W2143149828 citedByCount "20" @default.
• W2143149828 countsByYear W21431498282014 @default.
• W2143149828 countsByYear W21431498282015 @default.
• W2143149828 countsByYear W21431498282016 @default.
• W2143149828 countsByYear W21431498282017 @default.
• W2143149828 countsByYear W21431498282018 @default.
• W2143149828 countsByYear W21431498282020 @default.
• W2143149828 countsByYear W21431498282021 @default.
• W2143149828 countsByYear W21431498282022 @default.
• W2143149828 countsByYear W21431498282023 @default.
• W2143149828 crossrefType "journal-article" @default.
• W2143149828 hasAuthorship W2143149828A5005738758 @default.
• W2143149828 hasAuthorship W2143149828A5033224676 @default.
• W2143149828 hasAuthorship W2143149828A5037307065 @default.
• W2143149828 hasAuthorship W2143149828A5044032784 @default.
• W2143149828 hasAuthorship W2143149828A5077375577 @default.
• W2143149828 hasAuthorship W2143149828A5077633544 @default.
• W2143149828 hasBestOaLocation W21431498281 @default.
• W2143149828 hasConcept C104317684 @default.
• W2143149828 hasConcept C126322002 @default.
• W2143149828 hasConcept C134018914 @default.
• W2143149828 hasConcept C145059251 @default.
• W2143149828 hasConcept C150194340 @default.
• W2143149828 hasConcept C172680121 @default.
• W2143149828 hasConcept C186836561 @default.
• W2143149828 hasConcept C2779234561 @default.
• W2143149828 hasConcept C2781041448 @default.
• W2143149828 hasConcept C2993291352 @default.
• W2143149828 hasConcept C526584372 @default.
• W2143149828 hasConcept C54355233 @default.
• W2143149828 hasConcept C71315377 @default.
• W2143149828 hasConcept C71924100 @default.

• next