Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143151921> ?p ?o ?g. }
- W2143151921 abstract "In many mouse models of skin cancer, only a few tumors typically form even though many cells competent for tumorigenesis receive the same oncogenic stimuli. These observations suggest an active selection process for tumor-initiating cells. Here, we use quantitative mRNA- and miR-Seq to determine the impact of Hras G12V on the transcriptome of keratinocytes. We discover that microRNA-203 is downregulated by Hras G12V . Using a knockout mouse model, we demonstrate that loss of microRNA-203 promotes selection and expansion of tumor-initiating cells. Conversely, restoration of microRNA-203 using an inducible model potently inhibits proliferation of these cells. We comprehensively identify microRNA-203 targets required for Hras -initiated tumorigenesis. These targets include critical regulators of the Ras pathway and essential genes required for cell division. This study establishes a role for the loss of microRNA-203 in promoting selection and expansion of Hras mutated cells and identifies a mechanism through which microRNA-203 antagonizes Hras -mediated tumorigenesis." @default.
- W2143151921 created "2016-06-24" @default.
- W2143151921 creator A5020550992 @default.
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- W2143151921 date "2015-07-23" @default.
- W2143151921 modified "2023-10-17" @default.
- W2143151921 title "MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells" @default.
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- W2143151921 doi "https://doi.org/10.7554/elife.07004" @default.
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