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• W2143159623 abstract "Abstract Excessive trafficking of leukocytes can lead to serious tissue injury. Here, four regioselectively sulfated chitosans were assessed as inhibitors of HL-60 leukocyte binding to P-selectin, by investigating their effect on leukocyte adhesion to CHO cells expressing human P-selectin under static and flow conditions. The results show that the sulfochitosans exhibit inhibitory activity in this general order: heparin > N-sulfated/6-O-sulfated chitosan ≥ 3-O,6-O-sulfated chitosan > 6-O-sulfated chitosan ≫ N-sulfated chitosan. This suggests that the sulfation of the double site in chitosan is essential for efficient inhibition of P-selectin-mediated HL-60 leukocyte adhesion and that such sulfochitosans may have potential as therapeutic agents against inflammatory disease." @default.
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• W2143159623 date "2013-01-01" @default.
• W2143159623 modified "2023-09-29" @default.
• W2143159623 title "Sulfochitosan inhibits P-selectin-mediated HL-60 leukocyte adhesion under flow conditions" @default.
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• W2143159623 doi "https://doi.org/10.2478/s11658-013-0084-1" @default.
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