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- W2143159986 abstract "ABSTRACT The BarA-UvrY two-component system (TCS) in Escherichia coli is known to regulate a number of phenotypic traits. Both in vitro and in vivo assays, including the chicken embryo lethality assay, showed that this TCS regulates virulence in avian pathogenic E. coli (APEC) serotype O78:K80:H9. A number of virulence determinants, such as the abilities to adhere, invade, persist within tissues, survive within macrophages, and resist bactericidal effects of serum complement, were compromised in mutants lacking either the barA or uvrY gene. The reduced virulence was attributed to down regulation of type 1 and Pap fimbriae, reduced exopolysaccharide production, and increased susceptibility to oxidative stress. Our results indicate that BarA-UvrY regulates virulence properties in APEC and that the chicken embryo lethality assay can be used as a surrogate model to determine virulence determinants and their regulation in APEC strains." @default.
- W2143159986 created "2016-06-24" @default.
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- W2143159986 date "2006-08-01" @default.
- W2143159986 modified "2023-10-11" @default.
- W2143159986 title "The BarA-UvrY Two-Component System Regulates Virulence in Avian Pathogenic <i>Escherichia coli</i> O78:K80:H9" @default.
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- W2143159986 doi "https://doi.org/10.1128/iai.00412-06" @default.
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