Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143173105> ?p ?o ?g. }
- W2143173105 abstract "Trypanosomiasis and leishmaniasis are two debilitating disease groups caused by parasites of Trypanosoma and Leishmania spp. and affecting millions of people worldwide. A brief outline of the potential targets for rational drug design against these diseases are presented, with an emphasis placed on the enzyme trypanothione reductase. Trypanothione reductase was identified as unique to parasites and proposed to be an effective target against trypanosomiasis and leishmaniasis. The biochemical basis of selecting this enzyme as a target, with reference to the simile and contrast to human analogous enzyme glutathione reductase, and the structural aspects of its active site are presented. The process of designing selective inhibitors for the enzyme trypanothione reductase has been discussed. An overview of the different chemical classes of inhibitors of trypanothione reductase with their inhibitory activities against the parasites and their prospects as future chemotherapeutic agents are briefly revealed." @default.
- W2143173105 created "2016-06-24" @default.
- W2143173105 creator A5076541930 @default.
- W2143173105 date "2007-01-01" @default.
- W2143173105 modified "2023-09-23" @default.
- W2143173105 title "Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design." @default.
- W2143173105 cites W10267725 @default.
- W2143173105 cites W1491988998 @default.
- W2143173105 cites W1574734617 @default.
- W2143173105 cites W1585308289 @default.
- W2143173105 cites W1592195230 @default.
- W2143173105 cites W1604646983 @default.
- W2143173105 cites W1743444384 @default.
- W2143173105 cites W1817105817 @default.
- W2143173105 cites W1823258013 @default.
- W2143173105 cites W1896631934 @default.
- W2143173105 cites W1965388874 @default.
- W2143173105 cites W1966263769 @default.
- W2143173105 cites W1967866945 @default.
- W2143173105 cites W1973887930 @default.
- W2143173105 cites W1976830858 @default.
- W2143173105 cites W1980257407 @default.
- W2143173105 cites W1986962250 @default.
- W2143173105 cites W1989369846 @default.
- W2143173105 cites W1991428543 @default.
- W2143173105 cites W1996393950 @default.
- W2143173105 cites W1997310440 @default.
- W2143173105 cites W2001311382 @default.
- W2143173105 cites W2001957365 @default.
- W2143173105 cites W2002980997 @default.
- W2143173105 cites W2006184077 @default.
- W2143173105 cites W2006723796 @default.
- W2143173105 cites W2009649118 @default.
- W2143173105 cites W2009746444 @default.
- W2143173105 cites W2010015373 @default.
- W2143173105 cites W2011344657 @default.
- W2143173105 cites W2016535624 @default.
- W2143173105 cites W2017140568 @default.
- W2143173105 cites W2019446177 @default.
- W2143173105 cites W2023356380 @default.
- W2143173105 cites W2025955083 @default.
- W2143173105 cites W2025978382 @default.
- W2143173105 cites W2027003225 @default.
- W2143173105 cites W2027602317 @default.
- W2143173105 cites W2030180741 @default.
- W2143173105 cites W2033695597 @default.
- W2143173105 cites W2034454636 @default.
- W2143173105 cites W2035824043 @default.
- W2143173105 cites W2035855774 @default.
- W2143173105 cites W2036330755 @default.
- W2143173105 cites W2039888692 @default.
- W2143173105 cites W2040369578 @default.
- W2143173105 cites W2042571733 @default.
- W2143173105 cites W2045265357 @default.
- W2143173105 cites W2045915921 @default.
- W2143173105 cites W2046213732 @default.
- W2143173105 cites W2047838065 @default.
- W2143173105 cites W2049013030 @default.
- W2143173105 cites W2051752014 @default.
- W2143173105 cites W2052075760 @default.
- W2143173105 cites W2052564966 @default.
- W2143173105 cites W2054591552 @default.
- W2143173105 cites W2055194259 @default.
- W2143173105 cites W2055205561 @default.
- W2143173105 cites W2057080473 @default.
- W2143173105 cites W2059027852 @default.
- W2143173105 cites W2059953844 @default.
- W2143173105 cites W2059975739 @default.
- W2143173105 cites W2065081489 @default.
- W2143173105 cites W2070034593 @default.
- W2143173105 cites W2070211116 @default.
- W2143173105 cites W2072079428 @default.
- W2143173105 cites W2072097917 @default.
- W2143173105 cites W2075055658 @default.
- W2143173105 cites W2075178763 @default.
- W2143173105 cites W2075224137 @default.
- W2143173105 cites W2078783287 @default.
- W2143173105 cites W2080888478 @default.
- W2143173105 cites W2083678132 @default.
- W2143173105 cites W2087158727 @default.
- W2143173105 cites W2096197202 @default.
- W2143173105 cites W2103181632 @default.
- W2143173105 cites W2106837596 @default.
- W2143173105 cites W2109643580 @default.
- W2143173105 cites W2116251790 @default.
- W2143173105 cites W2130432349 @default.
- W2143173105 cites W2141244896 @default.
- W2143173105 cites W2142468661 @default.
- W2143173105 cites W2148686101 @default.
- W2143173105 cites W2161026946 @default.
- W2143173105 cites W2164679842 @default.
- W2143173105 cites W2167047804 @default.
- W2143173105 cites W2179459165 @default.
- W2143173105 cites W2202496068 @default.
- W2143173105 cites W2213481583 @default.
- W2143173105 cites W2262922019 @default.
- W2143173105 cites W2279417831 @default.
- W2143173105 cites W2321540468 @default.
- W2143173105 cites W2487661078 @default.
- W2143173105 cites W2953374754 @default.