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• W2143173516 abstract "Coenzyme Q(n) is a fully substituted benzoquinone containing a polyisoprene tail of distinct numbers (n) of isoprene groups. Caenorhabditis elegans fed Escherichia coli devoid of Q(8) have a significant lifespan extension when compared to C. elegans fed a standard 'Q-replete'E. coli diet. Here we examine possible mechanisms for the lifespan extension caused by the Q-less E. coli diet. A bioassay for Q uptake shows that a water-soluble formulation of Q(10) is effectively taken up by both clk-1 mutant and wild-type nematodes, but does not reverse lifespan extension mediated by the Q-less E. coli diet, indicating that lifespan extension is not due to the absence of dietary Q per se. The enhanced longevity mediated by the Q-less E. coli diet cannot be attributed to dietary restriction, different Qn isoforms, reduced pathogenesis or slowed growth of the Q-less E. coli, and in fact requires E. coli viability. Q-less E. coli have defects in respiratory metabolism. C. elegans fed Q-replete E. coli mutants with similarly impaired respiratory metabolism due to defects in complex V also show a pronounced lifespan extension, although not as dramatic as those fed the respiratory deficient Q-less E. coli diet. The data suggest that feeding respiratory incompetent E. coli, whether Q-less or Q-replete, produces a robust life extension in wild-type C. elegans. We believe that the fermentation-based metabolism of the E. coli diet is an important parameter of C. elegans longevity." @default.
• W2143173516 created "2016-06-24" @default.
• W2143173516 creator A5017034144 @default.
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• W2143173516 date "2008-06-01" @default.
• W2143173516 modified "2023-09-28" @default.
• W2143173516 title "Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q" @default.
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• W2143173516 doi "https://doi.org/10.1111/j.1474-9726.2008.00378.x" @default.
• W2143173516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3104051" @default.
• W2143173516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18267002" @default.
• W2143173516 hasPublicationYear "2008" @default.
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