FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143176554> ?p ?o ?g. }

• W2143176554 endingPage "665" @default.
• W2143176554 startingPage "651" @default.
• W2143176554 abstract "Abstract There is currently a need for effective pharmacological therapies for treatment of obesity. In this communication, the involvement of the neurotransmitter histamine in the regulation of food intake is reviewed, together with results obtained in animals with pharmacologically increased brain histamine levels. A survey of the literature reveals that histaminergic circuits, arising from nerve cell bodies in the tuberomammillary nucleus and projecting into the paraventricular nucleus, the arcuate nucleus, and the ventromedial hypothalamus, are strongly involved in regulation of food intake and possibly also energy expenditure. Current literature also suggests the histaminergic circuits connect to other neuronal pathways involved in the regulation of energy balance and body weight. Studies performed in rodents demonstrate that H 3 receptor antagonists increase hypothalamic histamine and decrease food intake, which result in decreased body weight. Lipid oxidation is increased and, at higher doses, body fat is also decreased. These changes are associated with lower circulating levels of insulin during an oral glucose challenge suggesting an increase in insulin sensitivity. The effects on food intake have also been confirmed in pigs and rhesus monkeys. It can thus be concluded that results obtained with H 3 antagonist in animals warrant future clinical studies to evaluate whether this principle is effective in the treatment of human obesity. Drug Dev. Res. 67:651–665, 2006. © 2006 Wiley‐Liss, Inc." @default.
• W2143176554 created "2016-06-24" @default.
• W2143176554 creator A5015356195 @default.
• W2143176554 creator A5044655949 @default.
• W2143176554 creator A5079801176 @default.
• W2143176554 date "2006-08-01" @default.
• W2143176554 modified "2023-09-25" @default.
• W2143176554 title "Targeting of the central histaminergic system for treatment of obesity and associated metabolic disorders" @default.
• W2143176554 cites W1486463812 @default.
• W2143176554 cites W1506453366 @default.
• W2143176554 cites W1533469234 @default.
• W2143176554 cites W1561443084 @default.
• W2143176554 cites W1632594403 @default.
• W2143176554 cites W1752589668 @default.
• W2143176554 cites W1798044890 @default.
• W2143176554 cites W1860002328 @default.
• W2143176554 cites W1914135415 @default.
• W2143176554 cites W1930515007 @default.
• W2143176554 cites W1964455885 @default.
• W2143176554 cites W1964922357 @default.
• W2143176554 cites W1965414505 @default.
• W2143176554 cites W1966688432 @default.
• W2143176554 cites W1973493996 @default.
• W2143176554 cites W1974760551 @default.
• W2143176554 cites W1975152841 @default.
• W2143176554 cites W1976801672 @default.
• W2143176554 cites W1976862870 @default.
• W2143176554 cites W1978259628 @default.
• W2143176554 cites W1978771408 @default.
• W2143176554 cites W1979842769 @default.
• W2143176554 cites W1980899216 @default.
• W2143176554 cites W1987688650 @default.
• W2143176554 cites W1988032261 @default.
• W2143176554 cites W1990809315 @default.
• W2143176554 cites W1994096988 @default.
• W2143176554 cites W1994493595 @default.
• W2143176554 cites W1995660637 @default.
• W2143176554 cites W2000367437 @default.
• W2143176554 cites W2000374834 @default.
• W2143176554 cites W2010817594 @default.
• W2143176554 cites W2012889100 @default.
• W2143176554 cites W2013291672 @default.
• W2143176554 cites W2021631954 @default.
• W2143176554 cites W2022628868 @default.
• W2143176554 cites W2027627629 @default.
• W2143176554 cites W2027903947 @default.
• W2143176554 cites W2029578168 @default.
• W2143176554 cites W2031722229 @default.
• W2143176554 cites W2032048326 @default.
• W2143176554 cites W2034810986 @default.
• W2143176554 cites W2034976118 @default.
• W2143176554 cites W2037744993 @default.
• W2143176554 cites W2038778104 @default.
• W2143176554 cites W2038951352 @default.
• W2143176554 cites W2039031830 @default.
• W2143176554 cites W2043551756 @default.
• W2143176554 cites W2044220059 @default.
• W2143176554 cites W2045140078 @default.
• W2143176554 cites W2048223707 @default.
• W2143176554 cites W2048326254 @default.
• W2143176554 cites W2052628599 @default.
• W2143176554 cites W2053708105 @default.
• W2143176554 cites W2056642586 @default.
• W2143176554 cites W2058159881 @default.
• W2143176554 cites W2059012840 @default.
• W2143176554 cites W2062320582 @default.
• W2143176554 cites W2062535911 @default.
• W2143176554 cites W2062590338 @default.
• W2143176554 cites W2062805720 @default.
• W2143176554 cites W2065726803 @default.
• W2143176554 cites W2066888335 @default.
• W2143176554 cites W2067032924 @default.
• W2143176554 cites W2069721792 @default.
• W2143176554 cites W2070178149 @default.
• W2143176554 cites W2071273152 @default.
• W2143176554 cites W2071596004 @default.
• W2143176554 cites W2072640381 @default.
• W2143176554 cites W2072694939 @default.
• W2143176554 cites W2073821618 @default.
• W2143176554 cites W2074184025 @default.
• W2143176554 cites W2074969045 @default.
• W2143176554 cites W2076533950 @default.
• W2143176554 cites W2076906435 @default.
• W2143176554 cites W2077687762 @default.
• W2143176554 cites W2081450943 @default.
• W2143176554 cites W2081498148 @default.
• W2143176554 cites W2085577426 @default.
• W2143176554 cites W2085596664 @default.
• W2143176554 cites W2086018460 @default.
• W2143176554 cites W2086599445 @default.
• W2143176554 cites W2086828949 @default.
• W2143176554 cites W2088228619 @default.
• W2143176554 cites W2089633163 @default.
• W2143176554 cites W2089673855 @default.
• W2143176554 cites W2094383019 @default.
• W2143176554 cites W2094605937 @default.
• W2143176554 cites W2102729381 @default.
• W2143176554 cites W2102773142 @default.

• next