Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143179619> ?p ?o ?g. }
- W2143179619 endingPage "8" @default.
- W2143179619 startingPage "41" @default.
- W2143179619 abstract "The aim of the present study was to investigate the anticancer properties of five alkaloids isolated from Amaryllidaceae, including the inhibitory effect on P-glycoprotein (P-gp) and the apoptosis-inducing capacity. The tested alkaloids were evaluated for their multidrug resistance (MDR)-reversing activity on human MDR1-gene-transfected L5178 mouse lymphoma cells, using the rhodamine-123 (Rh-123) assay. Trisphaeridine and pretazettine increased the intracellular Rh-123 concentration 30- and 50-fold, respectively, as compared to the non-treated cells, and 2-O-acetyllycorine and trisphaeridine were demonstrated by means of the checkerboard method to enhance the antiproliferative activity of doxorubicin on L5178 MDR mouse lymphoma cells. The MTT assay revealed that pretazettine, trisphaeridine and 2-O-acetyllycorine displayed excellent antiproliferative effects on both the human and the mouse cell lines. The apoptosis-inducing activities of selected agents (2-O-acetyllycorine and trisphaeridine) were measured via acridine orange and ethidium bromide dual staining and flow cytometry of the subG1 population." @default.
- W2143179619 created "2016-06-24" @default.
- W2143179619 creator A5015978490 @default.
- W2143179619 creator A5021567722 @default.
- W2143179619 creator A5047876047 @default.
- W2143179619 creator A5052576897 @default.
- W2143179619 creator A5058006275 @default.
- W2143179619 creator A5087455038 @default.
- W2143179619 date "2009-04-17" @default.
- W2143179619 modified "2023-09-23" @default.
- W2143179619 title "Antitumor activity of alkaloids derived from Amaryllidaceae species." @default.
- W2143179619 cites W1489453222 @default.
- W2143179619 cites W1539469412 @default.
- W2143179619 cites W1963725379 @default.
- W2143179619 cites W1974186010 @default.
- W2143179619 cites W1975463072 @default.
- W2143179619 cites W1976424977 @default.
- W2143179619 cites W1986970006 @default.
- W2143179619 cites W1987858462 @default.
- W2143179619 cites W2003263277 @default.
- W2143179619 cites W2004721608 @default.
- W2143179619 cites W2005490888 @default.
- W2143179619 cites W2012671411 @default.
- W2143179619 cites W2013781938 @default.
- W2143179619 cites W2023886434 @default.
- W2143179619 cites W2026368124 @default.
- W2143179619 cites W2029493749 @default.
- W2143179619 cites W2036707802 @default.
- W2143179619 cites W2040286969 @default.
- W2143179619 cites W2040517816 @default.
- W2143179619 cites W2040703381 @default.
- W2143179619 cites W2043557910 @default.
- W2143179619 cites W2044264173 @default.
- W2143179619 cites W2053855680 @default.
- W2143179619 cites W2056355667 @default.
- W2143179619 cites W2061657090 @default.
- W2143179619 cites W2061771956 @default.
- W2143179619 cites W2067038367 @default.
- W2143179619 cites W2069549290 @default.
- W2143179619 cites W2070118782 @default.
- W2143179619 cites W2079240307 @default.
- W2143179619 cites W2091073184 @default.
- W2143179619 cites W2099134833 @default.
- W2143179619 cites W2108719290 @default.
- W2143179619 cites W2109838399 @default.
- W2143179619 cites W2114918609 @default.
- W2143179619 cites W2119214893 @default.
- W2143179619 cites W2123409005 @default.
- W2143179619 cites W2129605627 @default.
- W2143179619 cites W2151098840 @default.
- W2143179619 cites W2160663572 @default.
- W2143179619 cites W2169992673 @default.
- W2143179619 cites W2214232107 @default.
- W2143179619 cites W2274811202 @default.
- W2143179619 cites W2367058444 @default.
- W2143179619 cites W2408599922 @default.
- W2143179619 cites W84182309 @default.
- W2143179619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19368123" @default.
- W2143179619 hasPublicationYear "2009" @default.
- W2143179619 type Work @default.
- W2143179619 sameAs 2143179619 @default.
- W2143179619 citedByCount "13" @default.
- W2143179619 countsByYear W21431796192012 @default.
- W2143179619 countsByYear W21431796192013 @default.
- W2143179619 countsByYear W21431796192015 @default.
- W2143179619 countsByYear W21431796192016 @default.
- W2143179619 countsByYear W21431796192017 @default.
- W2143179619 countsByYear W21431796192018 @default.
- W2143179619 countsByYear W21431796192019 @default.
- W2143179619 countsByYear W21431796192021 @default.
- W2143179619 crossrefType "journal-article" @default.
- W2143179619 hasAuthorship W2143179619A5015978490 @default.
- W2143179619 hasAuthorship W2143179619A5021567722 @default.
- W2143179619 hasAuthorship W2143179619A5047876047 @default.
- W2143179619 hasAuthorship W2143179619A5052576897 @default.
- W2143179619 hasAuthorship W2143179619A5058006275 @default.
- W2143179619 hasAuthorship W2143179619A5087455038 @default.
- W2143179619 hasConcept C114851261 @default.
- W2143179619 hasConcept C133936738 @default.
- W2143179619 hasConcept C153911025 @default.
- W2143179619 hasConcept C178790620 @default.
- W2143179619 hasConcept C185592680 @default.
- W2143179619 hasConcept C190283241 @default.
- W2143179619 hasConcept C2776907736 @default.
- W2143179619 hasConcept C2776924795 @default.
- W2143179619 hasConcept C2777667214 @default.
- W2143179619 hasConcept C2778589691 @default.
- W2143179619 hasConcept C2779102032 @default.
- W2143179619 hasConcept C2780783641 @default.
- W2143179619 hasConcept C2908647359 @default.
- W2143179619 hasConcept C2910425318 @default.
- W2143179619 hasConcept C54355233 @default.
- W2143179619 hasConcept C552990157 @default.
- W2143179619 hasConcept C553184892 @default.
- W2143179619 hasConcept C55493867 @default.
- W2143179619 hasConcept C71240020 @default.
- W2143179619 hasConcept C71924100 @default.
- W2143179619 hasConcept C81885089 @default.