FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143194928> ?p ?o ?g. }

• W2143194928 endingPage "3772" @default.
• W2143194928 startingPage "3763" @default.
• W2143194928 abstract "The aim of the present work was to design and synthesize 4-(4-bromophenyl)-5-((5-((quinolin-8-yloxy)methyl)-1,3,4-oxadiazol-2-ylthio)methyl)-4H-1,2,4-triazole-3-thiol derivatives and evaluate them for in-vitro Antioxidant, Antibacterial, Antihypertensive activities against standards. Antioxidant properties by DPPH, 2-Deoxyribose assay and Lipid peroxidation assay against ascorbic acid, Mannitol and R-tocopherol standards were evaluated respectively. Antibacterial activity against Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae were evaluated. Angiotensin-I-converting enzyme (ACE-I) inhibition was studied by using standard lisinopril. 3 out of 10 synthesized compounds showed good in-vitro antioxidant and antibacterial activities. In antioxidant activity the compound 4d, which is 2-methyl 5,7-dichloro substitution on core 8-hydroxyquinoline showed least IC50(highest active) value i.e. 98.8 mg/ml in DPPH against 106.12 mg/ml of standard ascorbic acid, 127.2 mg/ml in 2-deoxyribose assay against 130.4 mg/ml of the standard mannitol and 131.6 mg/ml in lipid peroxidation assay against 138.81 mg/ml of standard R-tocopherol. Compounds 4b, 4c, 4a and 3d showed moderate antioxidant activity. The compounds 3d and 4d were found to have higher antimicrobial activity on E. coli and S. aureus. The compounds 4e, 4a and 4d showed % inhibition of 85.81, 68.53 and 55.66 at higher concentrations (1000 μg/μl) respectively when compared to standard lisinopril (73.33 % inhibition) in ACE-I inhibitory activity. Halo substituted 8-hydroxyquinoline moiety may be responsible for the effective antibacterial and antioxidant activities. Similarly methyl substituted 8-hydroxyquinoline moiety may be responsible for the effective ACE-I activity. Hence, further studies are also required to confirm the influence of electron withdrawing and donating group on the substitution moiety." @default.
• W2143194928 created "2016-06-24" @default.
• W2143194928 creator A5017613822 @default.
• W2143194928 creator A5035377640 @default.
• W2143194928 creator A5043002965 @default.
• W2143194928 date "2014-01-01" @default.
• W2143194928 modified "2023-09-27" @default.
• W2143194928 title "SYNTHESIS AND ANTIOXIDANT, ANTIBACTERIAL, ANTIHYPERTENSIVE ACTIVITIES OF 8-HYDROXYQUINOLINE APPENDED WITH OXADIAZOLE AND TRIAZOLE RINGS" @default.
• W2143194928 cites W1585662105 @default.
• W2143194928 cites W1966584097 @default.
• W2143194928 cites W1967095026 @default.
• W2143194928 cites W1968854079 @default.
• W2143194928 cites W1989806335 @default.
• W2143194928 cites W2017142470 @default.
• W2143194928 cites W2022308709 @default.
• W2143194928 cites W2022661628 @default.
• W2143194928 cites W2026611384 @default.
• W2143194928 cites W2030379622 @default.
• W2143194928 cites W2031596649 @default.
• W2143194928 cites W2036838733 @default.
• W2143194928 cites W2036888373 @default.
• W2143194928 cites W2039341215 @default.
• W2143194928 cites W2039592048 @default.
• W2143194928 cites W2048008261 @default.
• W2143194928 cites W2071656018 @default.
• W2143194928 cites W2075385925 @default.
• W2143194928 cites W2089427958 @default.
• W2143194928 cites W2091945670 @default.
• W2143194928 cites W2134824140 @default.
• W2143194928 cites W2735899580 @default.
• W2143194928 cites W2951843562 @default.
• W2143194928 cites W1515613836 @default.
• W2143194928 cites W1573400318 @default.
• W2143194928 cites W2174089575 @default.
• W2143194928 hasPublicationYear "2014" @default.
• W2143194928 type Work @default.
• W2143194928 sameAs 2143194928 @default.
• W2143194928 citedByCount "1" @default.
• W2143194928 countsByYear W21431949282015 @default.
• W2143194928 crossrefType "journal-article" @default.
• W2143194928 hasAuthorship W2143194928A5017613822 @default.
• W2143194928 hasAuthorship W2143194928A5035377640 @default.
• W2143194928 hasAuthorship W2143194928A5043002965 @default.
• W2143194928 hasConcept C13965031 @default.
• W2143194928 hasConcept C185592680 @default.
• W2143194928 hasConcept C2777709666 @default.
• W2143194928 hasConcept C2778004101 @default.
• W2143194928 hasConcept C2780104969 @default.
• W2143194928 hasConcept C2780829032 @default.
• W2143194928 hasConcept C2781401929 @default.
• W2143194928 hasConcept C2986274086 @default.
• W2143194928 hasConcept C31903555 @default.
• W2143194928 hasConcept C523546767 @default.
• W2143194928 hasConcept C54355233 @default.
• W2143194928 hasConcept C552990157 @default.
• W2143194928 hasConcept C55493867 @default.
• W2143194928 hasConcept C86803240 @default.
• W2143194928 hasConceptScore W2143194928C13965031 @default.
• W2143194928 hasConceptScore W2143194928C185592680 @default.
• W2143194928 hasConceptScore W2143194928C2777709666 @default.
• W2143194928 hasConceptScore W2143194928C2778004101 @default.
• W2143194928 hasConceptScore W2143194928C2780104969 @default.
• W2143194928 hasConceptScore W2143194928C2780829032 @default.
• W2143194928 hasConceptScore W2143194928C2781401929 @default.
• W2143194928 hasConceptScore W2143194928C2986274086 @default.
• W2143194928 hasConceptScore W2143194928C31903555 @default.
• W2143194928 hasConceptScore W2143194928C523546767 @default.
• W2143194928 hasConceptScore W2143194928C54355233 @default.
• W2143194928 hasConceptScore W2143194928C552990157 @default.
• W2143194928 hasConceptScore W2143194928C55493867 @default.
• W2143194928 hasConceptScore W2143194928C86803240 @default.
• W2143194928 hasIssue "9" @default.
• W2143194928 hasLocation W21431949281 @default.
• W2143194928 hasOpenAccess W2143194928 @default.
• W2143194928 hasPrimaryLocation W21431949281 @default.
• W2143194928 hasRelatedWork W156244005 @default.
• W2143194928 hasRelatedWork W1567229536 @default.
• W2143194928 hasRelatedWork W2061839595 @default.
• W2143194928 hasRelatedWork W2146535293 @default.
• W2143194928 hasRelatedWork W2148172313 @default.
• W2143194928 hasRelatedWork W2158658259 @default.
• W2143194928 hasRelatedWork W2292969149 @default.
• W2143194928 hasRelatedWork W2358954950 @default.
• W2143194928 hasRelatedWork W2509260555 @default.
• W2143194928 hasRelatedWork W2550249676 @default.
• W2143194928 hasRelatedWork W2611380870 @default.
• W2143194928 hasRelatedWork W2624259789 @default.
• W2143194928 hasRelatedWork W2771574891 @default.
• W2143194928 hasRelatedWork W2896563249 @default.
• W2143194928 hasRelatedWork W3015801827 @default.
• W2143194928 hasRelatedWork W3043507378 @default.
• W2143194928 hasRelatedWork W3073123617 @default.
• W2143194928 hasRelatedWork W3094118332 @default.
• W2143194928 hasRelatedWork W3175806322 @default.
• W2143194928 hasRelatedWork W2581708524 @default.
• W2143194928 hasVolume "4" @default.
• W2143194928 isParatext "false" @default.
• W2143194928 isRetracted "false" @default.

• next