FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143198543> ?p ?o ?g. }

• W2143198543 endingPage "1950" @default.
• W2143198543 startingPage "1943" @default.
• W2143198543 abstract "Calbindin-D28k (CaBP28k) belongs to a large class of eucaryotic proteins that bind calcium (Ca2+) to a specific helix-loop-helix structure. To date, this protein was mainly linked to brain, kidneys, and pancreas. Here, we demonstrate for the first time the existence of CaBP8k in the human placental trophoblasts of the human term placenta. Placental Ca2+ transfer from maternal to fetus is crucial for fetal development, although the biochemical mechanisms responsible for this process are largely unknown. In the current study, we have investigated the 45Ca2+ uptake by human trophoblast cells in correlation with the expression CaBP28k. The expression of CaBP28k was determined by Northern blot analysis, reverse transcriptase polymerase chain reaction (RT-PCR), immunochemistry, and Western blot analysis. Indeed, Northern blot analysis revealed the presence of a CaBP28k transcript in syncytiotrophoblasts, cytotrophoblast cells, and HEK-293 cells. This was further confirmed by RT-PCR analysis followed by sequencing. In addition, anti-CaBP28k labeling was associated with cytotrophoblast and syncytiotrophoblast tissues in placental tissue sections and in vitro cultured cells. The presence of CaBP28k protein in these cells was confirmed by Western blotting. Cytotrophoblast cells isolated from human term placenta showed differentiation into syncytiotrophoblasts in culture according to the increase in hCG secretion. Both Ca2+ uptake and hCG secretion by trophoblasts increased gradually and were high at Day 4. Taken together, these data suggest that CaBP28k may play a role in Ca2+ transport or cell development in human trophoblast possibly trough Ca2+ buffering." @default.
• W2143198543 created "2016-06-24" @default.
• W2143198543 creator A5002328416 @default.
• W2143198543 creator A5030530754 @default.
• W2143198543 creator A5047984123 @default.
• W2143198543 creator A5085725619 @default.
• W2143198543 creator A5087176959 @default.
• W2143198543 date "2003-06-01" @default.
• W2143198543 modified "2023-10-15" @default.
• W2143198543 title "Expression of Calbindin-D28k (CaBP28k) in Trophoblasts from Human Term Placenta1" @default.
• W2143198543 cites W1972482858 @default.
• W2143198543 cites W1979766583 @default.
• W2143198543 cites W1981264339 @default.
• W2143198543 cites W1982762633 @default.
• W2143198543 cites W1985424169 @default.
• W2143198543 cites W1988477685 @default.
• W2143198543 cites W1999610370 @default.
• W2143198543 cites W2011771725 @default.
• W2143198543 cites W2014457861 @default.
• W2143198543 cites W2025751554 @default.
• W2143198543 cites W2028032048 @default.
• W2143198543 cites W2031183930 @default.
• W2143198543 cites W2048168955 @default.
• W2143198543 cites W2051781190 @default.
• W2143198543 cites W2054843429 @default.
• W2143198543 cites W2056898007 @default.
• W2143198543 cites W2060287287 @default.
• W2143198543 cites W2065590405 @default.
• W2143198543 cites W2068573264 @default.
• W2143198543 cites W2085323240 @default.
• W2143198543 cites W2097019683 @default.
• W2143198543 cites W2097650481 @default.
• W2143198543 cites W2118309774 @default.
• W2143198543 cites W2130164653 @default.
• W2143198543 cites W2133659965 @default.
• W2143198543 cites W2167503858 @default.
• W2143198543 cites W2403228287 @default.
• W2143198543 cites W2412378618 @default.
• W2143198543 doi "https://doi.org/10.1095/biolreprod.102.009373" @default.
• W2143198543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12606474" @default.
• W2143198543 hasPublicationYear "2003" @default.
• W2143198543 type Work @default.
• W2143198543 sameAs 2143198543 @default.
• W2143198543 citedByCount "33" @default.
• W2143198543 countsByYear W21431985432013 @default.
• W2143198543 countsByYear W21431985432014 @default.
• W2143198543 countsByYear W21431985432016 @default.
• W2143198543 countsByYear W21431985432017 @default.
• W2143198543 countsByYear W21431985432018 @default.
• W2143198543 countsByYear W21431985432019 @default.
• W2143198543 countsByYear W21431985432020 @default.
• W2143198543 countsByYear W21431985432021 @default.
• W2143198543 countsByYear W21431985432022 @default.
• W2143198543 countsByYear W21431985432023 @default.
• W2143198543 crossrefType "journal-article" @default.
• W2143198543 hasAuthorship W2143198543A5002328416 @default.
• W2143198543 hasAuthorship W2143198543A5030530754 @default.
• W2143198543 hasAuthorship W2143198543A5047984123 @default.
• W2143198543 hasAuthorship W2143198543A5085725619 @default.
• W2143198543 hasAuthorship W2143198543A5087176959 @default.
• W2143198543 hasConcept C104317684 @default.
• W2143198543 hasConcept C150194340 @default.
• W2143198543 hasConcept C153911025 @default.
• W2143198543 hasConcept C159654299 @default.
• W2143198543 hasConcept C172680121 @default.
• W2143198543 hasConcept C177707886 @default.
• W2143198543 hasConcept C203014093 @default.
• W2143198543 hasConcept C2776415932 @default.
• W2143198543 hasConcept C2776953305 @default.
• W2143198543 hasConcept C2777495146 @default.
• W2143198543 hasConcept C2777605040 @default.
• W2143198543 hasConcept C2779234561 @default.
• W2143198543 hasConcept C2779315647 @default.
• W2143198543 hasConcept C2780659158 @default.
• W2143198543 hasConcept C2908795334 @default.
• W2143198543 hasConcept C54355233 @default.
• W2143198543 hasConcept C55493867 @default.
• W2143198543 hasConcept C85265743 @default.
• W2143198543 hasConcept C86803240 @default.
• W2143198543 hasConcept C95444343 @default.
• W2143198543 hasConceptScore W2143198543C104317684 @default.
• W2143198543 hasConceptScore W2143198543C150194340 @default.
• W2143198543 hasConceptScore W2143198543C153911025 @default.
• W2143198543 hasConceptScore W2143198543C159654299 @default.
• W2143198543 hasConceptScore W2143198543C172680121 @default.
• W2143198543 hasConceptScore W2143198543C177707886 @default.
• W2143198543 hasConceptScore W2143198543C203014093 @default.
• W2143198543 hasConceptScore W2143198543C2776415932 @default.
• W2143198543 hasConceptScore W2143198543C2776953305 @default.
• W2143198543 hasConceptScore W2143198543C2777495146 @default.
• W2143198543 hasConceptScore W2143198543C2777605040 @default.
• W2143198543 hasConceptScore W2143198543C2779234561 @default.
• W2143198543 hasConceptScore W2143198543C2779315647 @default.
• W2143198543 hasConceptScore W2143198543C2780659158 @default.
• W2143198543 hasConceptScore W2143198543C2908795334 @default.
• W2143198543 hasConceptScore W2143198543C54355233 @default.
• W2143198543 hasConceptScore W2143198543C55493867 @default.
• W2143198543 hasConceptScore W2143198543C85265743 @default.

• next