FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143221030> ?p ?o ?g. }

• W2143221030 abstract "Hepatobiliary and pancreatic disorders are some of the commonest disorders of the digestive system. The hepatopancreatobiliary system has a complex embryological development and therefore is subject to anomalies that may sometimes have deleterious implications on the body physiology, besides being associated with a spectrum of acquired problems that require specialized training to tackle surgically.Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial burden on the health care system. Pathogenesis is multifactorial and prevalence has increased in recent years amongst all segments of society probably due to changes in life style, alteration in dietary patterns, altered physical activity.1 Increasing awareness amongst the population and superior investigative modalities have in no small measure contributed to the rapid diagnosis and ease of management by surgeons and gastroenterologists. Laparoscopic cholecystectomy is a routine general surgical operation practiced all over the world and adoption of single incision laparoscopic cholecystectomy even in small volume hospitals is on the rise.2 And in common bile duct stones that often arise due to migration of gall stones, same session ERCP with stone extraction and laparoscopic cholecystectomy is likely to be an effective strategy3 in future.Amongst all the malignancies, cancer gall bladder is the fifth most common cancer. It is the most common biliary tract malignancy and is characterized as an aggressive and highly lethal disease with widespread discrepancy about its epidemiology, and its precise aetiology is as yet poorly understood. One of the highest incidences is in India, especially the Gangetic belt, and it has been hypothesized and substantiated in several studies that it is probably related to the high content of certain minerals in the water of North India. Surgical resection appears to be the only potential curative approach, but unfortunately a mere minority is eligible for surgery at presentation.4,5The liver is a highly vascular organ and it has complex tasks of both synthesis and detoxification. Hence it becomes a fertile ground for harbouring infections and infestations. Even though the quality of antibiotics has improved with time, the incidence of liver abscesses has not decreased proportionately. On the other hand, with increasing intervention in the hepatobiliary system, iatrogenic causes of hepatic abscesses are worrisome. So the trend seems to be a shift from a high incidence in the young to average ages in the fifth to sixth decades of life.6 With improved methods of tackling parasitic infestations like ascariasis and hydatid cysts, morbidity is considerably low in recent times and there is a noticeable fall in the overall incidence.7The inevitable consequences of untreated calculi or intervention on the biliary tree, both therapeutically and for injuries, have led to problems like biliary strictures that demand early surgical management. Till about a decade ago, with introduction of ERCP and laparoscopy there was a sudden spurt in this entity. But with improved training, and treatment protocols being laid down based on evidence; mercifully the incidence has started to fall rapidly and more or less has reached a plateau. Biliary tract strictures present both diagnostic and therapeutic challenges to clinicians. Advances in imaging and endoscopic techniques have improved our ability to differentiate between benign and malignant lesions. Intraductal ultrasound has a sensitivity and specificity of 89% and 84% respectively. Intraductal ultrasound and percutaneous transhepatic biliary endoscopy are promising new modalities for diagnosing and treating biliary strictures.8Choledochal cysts are a rare developmental problem in the biliary tree, more frequent in Asia than in Europe or North America.9 Imaging modalities have helped us define correctly the extent and nature of the cyst; with improved surgical techniques we can tackle a large number of these disorders with excellent results.Chronic pancreatitis is a progressive fibro inflammatory disease that exists in large duct (often with intraductal calculi) or small duct forms, and often results from a complex mix of environmental and genetic factors with pain as a predominant symptom.10 With increasing trend in alcohol use and a rising incidence of gall stones in both males and females one sees a steady rise in incidence of pancreatitis also. However, there is nothing to suggest that idiopathic chronic pancreatitis in India is a different disease.11 Pancreatitis with the consequences of chronic pain, pseudo cyst formation and secondary exocrine and endocrine disorders is a common cause of loss of man hours in an active population. Though the management of pancreatic cancer has a well planned protocol, chronic pancreatitis continues to be a problem with no certainty of cure. Morbidity remains high and major surgery has never been an answer to the vexing issue in the prime of one’s life. The very fact that there exists a number of surgical options to choose from is in itself evidence to prove how unsatisfactory its management is.The cause of pancreatic cancer remains unknown with an estimated 5-year survival of less than 5%. Though important advances have been made in understanding the molecular biology, several environmental factors are postulated to be causative and at least upto 10% may have a positive family history.12Portal hypertension, which often presents as an emergency upper GI bleed is still a concern in our country, both in the paediatric and adult age groups. In the recent years, data from the Indian subcontinent has started coming in and several centres in the country have produced good results following shunt surgery. EHPVO (54%) and cirrhosis (39%) are the two major causes of portal hypertension in children, the predominant cause of bleeding being in the former.13 However the outlook in cirrhotics continues to be dismal and liver transplant is a distant dream as yet, to the multitude of cirrhotics with portal hypertension.To conclude, it is gratifying to note that the plethora of problems related to the hepatopancreatobiliary system is being addressed. Molecular biology has opened up many avenues unheard of so far, imaging has widened the scope of early diagnosis and intervention, surgical techniques have vastly improved and there has been a fall in morbidity and mortality in many areas." @default.
• W2143221030 created "2016-06-24" @default.
• W2143221030 creator A5021062930 @default.
• W2143221030 date "2012-07-01" @default.
• W2143221030 modified "2023-09-30" @default.
• W2143221030 title "Hepatobiliary and pancreatic disorders" @default.
• W2143221030 cites W1975992566 @default.
• W2143221030 cites W1983316414 @default.
• W2143221030 cites W2002797523 @default.
• W2143221030 cites W2053815151 @default.
• W2143221030 cites W2058004200 @default.
• W2143221030 cites W2106825877 @default.
• W2143221030 cites W2132229010 @default.
• W2143221030 cites W2148582246 @default.
• W2143221030 cites W2321565339 @default.
• W2143221030 cites W3134530972 @default.
• W2143221030 cites W3191027622 @default.
• W2143221030 doi "https://doi.org/10.1016/j.mjafi.2012.04.005" @default.
• W2143221030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3862873" @default.
• W2143221030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24532869" @default.
• W2143221030 hasPublicationYear "2012" @default.
• W2143221030 type Work @default.
• W2143221030 sameAs 2143221030 @default.
• W2143221030 citedByCount "0" @default.
• W2143221030 crossrefType "journal-article" @default.
• W2143221030 hasAuthorship W2143221030A5021062930 @default.
• W2143221030 hasBestOaLocation W21432210302 @default.
• W2143221030 hasConcept C107130276 @default.
• W2143221030 hasConcept C121608353 @default.
• W2143221030 hasConcept C126322002 @default.
• W2143221030 hasConcept C137627325 @default.
• W2143221030 hasConcept C141071460 @default.
• W2143221030 hasConcept C142724271 @default.
• W2143221030 hasConcept C177713679 @default.
• W2143221030 hasConcept C2776641081 @default.
• W2143221030 hasConcept C2776884468 @default.
• W2143221030 hasConcept C2779134260 @default.
• W2143221030 hasConcept C2779399171 @default.
• W2143221030 hasConcept C2780210213 @default.
• W2143221030 hasConcept C2908647359 @default.
• W2143221030 hasConcept C61434518 @default.
• W2143221030 hasConcept C71924100 @default.
• W2143221030 hasConcept C99454951 @default.
• W2143221030 hasConceptScore W2143221030C107130276 @default.
• W2143221030 hasConceptScore W2143221030C121608353 @default.
• W2143221030 hasConceptScore W2143221030C126322002 @default.
• W2143221030 hasConceptScore W2143221030C137627325 @default.
• W2143221030 hasConceptScore W2143221030C141071460 @default.
• W2143221030 hasConceptScore W2143221030C142724271 @default.
• W2143221030 hasConceptScore W2143221030C177713679 @default.
• W2143221030 hasConceptScore W2143221030C2776641081 @default.
• W2143221030 hasConceptScore W2143221030C2776884468 @default.
• W2143221030 hasConceptScore W2143221030C2779134260 @default.
• W2143221030 hasConceptScore W2143221030C2779399171 @default.
• W2143221030 hasConceptScore W2143221030C2780210213 @default.
• W2143221030 hasConceptScore W2143221030C2908647359 @default.
• W2143221030 hasConceptScore W2143221030C61434518 @default.
• W2143221030 hasConceptScore W2143221030C71924100 @default.
• W2143221030 hasConceptScore W2143221030C99454951 @default.
• W2143221030 hasLocation W21432210301 @default.
• W2143221030 hasLocation W21432210302 @default.
• W2143221030 hasLocation W21432210303 @default.
• W2143221030 hasLocation W21432210304 @default.
• W2143221030 hasOpenAccess W2143221030 @default.
• W2143221030 hasPrimaryLocation W21432210301 @default.
• W2143221030 hasRelatedWork W1565790047 @default.
• W2143221030 hasRelatedWork W1979521583 @default.
• W2143221030 hasRelatedWork W1988413875 @default.
• W2143221030 hasRelatedWork W1989937600 @default.
• W2143221030 hasRelatedWork W2014359566 @default.
• W2143221030 hasRelatedWork W2040586952 @default.
• W2143221030 hasRelatedWork W2074235434 @default.
• W2143221030 hasRelatedWork W2078772756 @default.
• W2143221030 hasRelatedWork W2332489601 @default.
• W2143221030 hasRelatedWork W2333386549 @default.
• W2143221030 hasRelatedWork W2397328124 @default.
• W2143221030 hasRelatedWork W2409721041 @default.
• W2143221030 hasRelatedWork W2411110882 @default.
• W2143221030 hasRelatedWork W2412182248 @default.
• W2143221030 hasRelatedWork W2414964117 @default.
• W2143221030 hasRelatedWork W3046364429 @default.
• W2143221030 hasRelatedWork W3046604647 @default.
• W2143221030 hasRelatedWork W3166787896 @default.
• W2143221030 hasRelatedWork W67623868 @default.
• W2143221030 hasRelatedWork W2289554674 @default.
• W2143221030 isParatext "false" @default.
• W2143221030 isRetracted "false" @default.
• W2143221030 magId "2143221030" @default.
• W2143221030 workType "article" @default.